Biology Chapter on Chromosomes
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Questions and Answers

What is the first phase of mitosis?

  • Metaphase
  • Prophase (correct)
  • Telophase
  • Anaphase

During which mitotic phase do chromosomes align in the center of the cell?

  • Anaphase
  • Prophase
  • Metaphase (correct)
  • Telophase

What occurs during the Anaphase stage of mitosis?

  • Sister chromatids move toward opposite ends of the cell (correct)
  • Chromosomes condense and become visible
  • The nuclear envelope reforms around chromatin
  • The cell begins cytoplasmic division

What happens to the nuclear envelope during Prophase?

<p>It breaks down and disappears (C)</p> Signup and view all the answers

Which checkpoint determines if a cell should enter the S phase of the cell cycle?

<p>G1 checkpoint (D)</p> Signup and view all the answers

What initiates the exit process from the M phase of the cell cycle?

<p>M checkpoint (C)</p> Signup and view all the answers

Which of the following can occur if severe errors are found in genetic material during the cell cycle?

<p>Apoptosis occurs (D)</p> Signup and view all the answers

What is cytokinesis and when does it begin?

<p>It is the division of the cytoplasm, beginning during Telophase (C)</p> Signup and view all the answers

What role do proto-oncogenes play in cell division?

<p>Stimulate cell division (C)</p> Signup and view all the answers

What characterizes a benign tumor?

<p>It is encapsulated and usually remains at its site (A)</p> Signup and view all the answers

What happens when tumor-suppressor genes undergo mutations?

<p>They prevent the cell cycle from stopping at checkpoints (C)</p> Signup and view all the answers

What does metastasis refer to in the context of malignant tumors?

<p>The spread of cancer cells to distant parts of the body (B)</p> Signup and view all the answers

How do cancer cells typically behave differently than normal cells?

<p>They become immortalized and do not undergo cell death (C)</p> Signup and view all the answers

What is one known cause of DNA mutations that can lead to cancer?

<p>Inherited genetic factors (D)</p> Signup and view all the answers

What is angiogenesis in the context of cancer cells?

<p>The creation of new blood vessels to supply tumors (B)</p> Signup and view all the answers

How do mutations in proto-oncogenes affect cell division?

<p>They can cause increased rates of cell division (A)</p> Signup and view all the answers

What is the role of histones in the structure of chromosomes?

<p>To help with the support and control of gene activity (C)</p> Signup and view all the answers

How many chromosomes do somatic cells in the human body contain?

<p>46 chromosomes (A)</p> Signup and view all the answers

During which phase of the cell cycle does DNA replication occur?

<p>S phase (D)</p> Signup and view all the answers

What is the function of the karyotype?

<p>To show the exact number and visual appearance of chromosomes (B)</p> Signup and view all the answers

Which of the following statements about diploid cells is true?

<p>Diploid cells have two sets of chromosomes from each parent (C)</p> Signup and view all the answers

What does the G0 phase of the cell cycle represent?

<p>A resting phase where cells are not dividing (B)</p> Signup and view all the answers

Which of the following correctly defines homologous chromosomes?

<p>Pairs of chromosomes, one from each parent (C)</p> Signup and view all the answers

Which phase of interphase involves major growth before DNA synthesis occurs?

<p>G1 phase (B)</p> Signup and view all the answers

What is the primary goal of radiation therapy in cancer treatment?

<p>To damage DNA in rapidly dividing cells (C)</p> Signup and view all the answers

How many autosomes are present in the total number of human chromosomes?

<p>44 autosomes (A)</p> Signup and view all the answers

Which of the following correctly describes the mitosis phase of the cell cycle?

<p>It occurs after the G2 phase. (B)</p> Signup and view all the answers

Which of the following accurately describes a limitation of chemotherapy?

<p>Many cancer cells may not self-destruct due to gene mutations (B)</p> Signup and view all the answers

Which method is utilized in gene therapy for cancer treatment?

<p>Inserting normal tumor-suppressor genes into cancerous cells (D)</p> Signup and view all the answers

What role do cytotoxic T cells play in immunotherapy?

<p>They destroy abnormal cells, including cancer cells (B)</p> Signup and view all the answers

Which substance is NOT mentioned as a known cause of cancer?

<p>Caffeine (C)</p> Signup and view all the answers

What is a characteristic side effect of radiation therapy?

<p>Nausea and hair loss (D)</p> Signup and view all the answers

Which type of cancer treatment is utilized primarily at diagnosis?

<p>Chemotherapy (C)</p> Signup and view all the answers

What is the purpose of immune checkpoint inhibitors in cancer treatment?

<p>To allow the immune system to respond more vigorously (B)</p> Signup and view all the answers

Flashcards

Chromosome

A tightly coiled structure of DNA around histone proteins in a cell's nucleus.

Histone

Proteins that DNA wraps around to form a chromosome.

Gene

A segment of DNA that directs protein synthesis.

Chromatin

DNA and histone proteins in a loose, thread-like form.

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Chromosome

A condensed form of chromatin, visible during cell division.

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Somatic cell

Any body cell (not a sex cell).

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Homologous pair

Pairs of chromosomes, one from each parent.

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Diploid cell

A cell with two sets of chromosomes.

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Haploid cell

A cell with one set of chromosomes.

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Autosome

Any chromosome not a sex chromosome.

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Sex chromosome

Determines biological sex.

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Karyotype

A picture of all chromosomes in a cell.

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Cell cycle

Sequence of events from cell origin to division.

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Interphase

Growth and preparation phase before cell division

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Mitosis

Cell division of somatic cells

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Cytokinesis

Division of the cytoplasm into two cells.

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G1 phase

Growth prior to DNA replication

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S phase

DNA replication occurs

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G2 phase

Growth and preparation before mitosis

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G0 phase

Cells not actively dividing

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Prophase

First stage of mitosis

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Metaphase

Chromosomes align at the center of the cell

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Anaphase

Sister chromatids separate and move to opposite poles

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Telophase

Final stage of mitosis - chromosomes decondense

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Cell cycle checkpoints

Control points ensuring accurate cell division

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Apoptosis

Programmed cell death

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Cancer

Uncontrolled cell growth and division diseases

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Tumor

An abnormal mass of cells

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Malignant tumor

Cancerous tumor that spreads

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Benign tumor

Non-cancerous tumor

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Metastasis

Spread of cancer to other parts of the body

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Proto-oncogene

Gene that promotes cell growth and division

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Tumor-suppressor gene

Gene that inhibits cell growth and division

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Carcinogen

cancer-causing agent

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Study Notes

Chromosomes

  • DNA is located within the nucleus.
  • A chromosome is DNA tightly coiled around proteins called histones.
  • Histones help with support and control of gene activity within a cell.
  • Genes are specific segments of DNA that direct protein synthesis, which plays a structural or functional role in the cell.

Chromatin, Chromosomes, and DNA

  • Chromatin is DNA and histones coiled into thin, thread-like structures that exist in the nucleus between cell divisions.
  • Chromosomes are the same DNA and histones super-condensed into thicker, visible structures that occur during cell division.

Chromosomes & Somatic Cells

  • All somatic cells (body cells except germ cells - eggs and sperm) have 46 chromosomes.
  • Two sets (pairs) of 23 chromosomes, with one set from each parent.
  • Each pair is called a homologous pair.
  • One chromosome of the pair is from the mother, and one chromosome of the pair is from the father.

Diploid & Haploid Cells

  • Diploid means a cell with two sets of chromosomes (one from each parent).
  • All cells in the human body are diploid (2n) except sperm and egg cells (haploid – n).
  • Genes also occur in pairs in diploid cells.
  • Each gene pair is located at the same position on homologous chromosomes.

Autosomes & Sex Chromosomes

  • 23 pairs of chromosomes total.
  • 22 pairs are called autosomes and determine expression of most inherited characteristics.
  • The last pair is sex chromosomes, determining the biological sex.
    • XX = genetic female
    • XY = genetic male

Karyotype

  • A karyotype is a complete set of chromosomes from a cell.
  • Shows the exact number and visual appearance of chromosomes, and can show anomalies.

The Cell Cycle

  • The cell cycle is a predictable set of events that a cell goes through from its origin to its own division into two daughter cells.
  • Two major phases:
    • Interphase - Growth and preparation for cell division.
    • Mitosis - Cell division for somatic cells.
  • Cytokinesis is the division of the cytoplasm into two distinct cells.

Interphase

  • Interphase is a period of growth and preparation for cell division.
  • Interphase has three phases: G1, S, and G2.
    • G1 phase - Major growth prior to DNA synthesis.
    • S phase - DNA is replicated, and the copies are called chromatids, which remain attached at the centromere.
    • G2 phase - Period after DNA is synthesized and before mitosis begins.

G0

  • Cells that have temporarily or permanently stopped dividing are in the G0 phase.

Cell Division

  • Consists of two processes:
    • Mitosis - Division of the nucleus.
    • Cytokinesis - Division of the cytoplasm.

Stages of Mitosis

  • Mitosis occurs in four phases:
    • Prophase - Centrioles migrate to the poles. DNA forms short, thick, double-stranded chromosomes. Nuclear envelope breaks down.
    • Metaphase - Mitotic spindle attaches to the centromere. Chromosomes align in the center of the cell along the equatorial plane.
    • Anaphase - Mitotic spindle pulls the chromosomes apart and sister chromatids move to opposite ends of the cell. The cell begins to elongate.
    • Telophase - Chromosomes uncoil. Nuclear envelope reforms around chromatin. Spindles break down.

Cytokinesis

  • Cytokinesis begins during telophase.
  • Physical dividing of cytoplasm, organelles, and cell membrane into two separate cells.
  • A ring of microfilaments contracts at the midline of the cell, eventually pinching the cell in two.

Cell Cycle Control

  • There are checkpoints where the genetic material is checked for errors and mutations.
  • Internal and external controls provide "stop" and "advance" signals to the cells.
  • If errors or mutations are discovered:
    • DNA repair occurs, if possible.
    • The cell cycle is arrested permanently if not repairable.
    • Apoptosis occurs if severe errors/mutations are discovered.

Checkpoints - Locations

  • G1 checkpoint - Determines whether the cell should divide and enter the S phase.
  • G2 checkpoint - Leads to mitosis.
  • M checkpoint - Occurs during metaphase and triggers the exit process from the M phase and entry into the G1 phase.

Regulation of the Cell Cycle

  • Two types of genes regulate normal cell division:
    • Proto-oncogenes - Stimulate cell division.
    • Tumor-suppressor genes - Inhibit cell division.
  • Programmed cell death (apoptosis) is initiated when genes regulating cell division are damaged.

Cancer

  • Cancer is a growth disorder of cells.
  • Abnormal cells grow uncontrollably and can damage surrounding tissues.
  • A growing cluster of cells is called a tumor or neoplasm.
  • There are two types of tumors:
    • Benign - Abnormal mass of tissue surrounded by healthy cells. Remains at the site where it forms.
    • Malignant - Not encapsulated. Invasive. Spreads to multiple locations via metastasis.

Mutations that Lead to Cancer

  • Cancer results from damaged genes that fail to control cell division.
  • Mutations in proto-oncogenes can speed up cell division.
  • Mutations in tumor-suppressor genes prevent the cell cycle from stopping at checkpoints when DNA is damaged.

Cancer Cells - Malignant Tumors

  • Cancer cells usually have 2 or more of the following characteristics:
    • Up-regulated oncogenes (mutated proto-oncogenes) or down-regulated tumor-suppressor genes, causing increased cell division and tumor development.
    • Do not undergo cell death and become "immortalized."
    • Spread to other regions of the body.
    • Cause growth of new blood vessels for nutrient access (angiogenesis).

Known Causes of Cancer

  • DNA mutations can be random, inherited, or caused by carcinogens.
  • Carcinogens are anything that fosters development of cancer:
    • Chemical carcinogens - May cause mutations in genes that regulate cell division.
    • Viruses - Cause about 5% of cancers in the U.S.
    • Radiation - Causes mutations in DNA, including cosmic rays, UV light, and radon.

Cancer Treatments

  • Surgery - When a tumor is accessible and can be removed without damaging vital tissue.
  • Radiation & Chemotherapy - Goal is to damage DNA in rapidly dividing cells.
  • Immunotherapy - Goal is to boost natural immune responses against cancer cells.
    • Immune checkpoint inhibitors allow the immune system to respond more vigorously than usual.
    • T-cell transfer is when T-cells attacking the tumor are removed, altered in a lab, and placed back into the tumor.
  • Gene therapy - Insert normal tumor-suppressor genes into cancerous cells, or a gene to prevent accelerated cell division.

Cancer Treatment Side Effects

  • Radiation and Chemotherapy have side effects because they kill healthy cells also.
    • Side effects include temporary sterility, nausea, anemia, and hair loss.

The importance of early detection in treating cancer

  • Early detection of cancer is crucial because the cancer is less likely to have spread to other parts of the body, which greatly increases the chances of successful treatment and increases the likelihood of complete recovery.

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Description

Explore the essential concepts of chromosomes, including their structure, function, and the differences between chromatin, diploid, and haploid cells. This quiz covers crucial topics regarding DNA organization and the role of histones in gene activity. Test your knowledge of somatic cells and genetic inheritance patterns.

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