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Questions and Answers
Which of the following biological structures is closest in size to a typical globular protein?
Which of the following biological structures is closest in size to a typical globular protein?
Which of the following statements accurately describes the relationship between size and resonance frequency in biological objects?
Which of the following statements accurately describes the relationship between size and resonance frequency in biological objects?
Which of these biological components would be most likely to exhibit significant quantum effects?
Which of these biological components would be most likely to exhibit significant quantum effects?
Which of the following is NOT a dominant force or effect at the nanoscale?
Which of the following is NOT a dominant force or effect at the nanoscale?
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Which of the following biological structures is most similar in size to a lysosome or peroxisome?
Which of the following biological structures is most similar in size to a lysosome or peroxisome?
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What type of environment did the early Earth's atmosphere provide?
What type of environment did the early Earth's atmosphere provide?
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What was a key finding of Miller's experiments in the 1950s?
What was a key finding of Miller's experiments in the 1950s?
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What molecule is considered to have been the primary genetic material in the RNA world?
What molecule is considered to have been the primary genetic material in the RNA world?
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What is the defining characteristic of prokaryotic cells?
What is the defining characteristic of prokaryotic cells?
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Which of the following is NOT a characteristic of prokaryotic cells?
Which of the following is NOT a characteristic of prokaryotic cells?
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What are the two major groups of prokaryotes?
What are the two major groups of prokaryotes?
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What is a key difference between archaebacteria and eubacteria?
What is a key difference between archaebacteria and eubacteria?
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What is a characteristic of thermoacidophiles?
What is a characteristic of thermoacidophiles?
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What is the range of DNA base pairs found in most bacterial cells?
What is the range of DNA base pairs found in most bacterial cells?
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What is the estimated time period for prokaryotic evolution?
What is the estimated time period for prokaryotic evolution?
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What is the primary function of the endoplasmic reticulum?
What is the primary function of the endoplasmic reticulum?
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What is the primary function of the Golgi apparatus?
What is the primary function of the Golgi apparatus?
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Which of the following is TRUE about the endosymbiotic theory?
Which of the following is TRUE about the endosymbiotic theory?
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What is the role of the outer membrane of mitochondria?
What is the role of the outer membrane of mitochondria?
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What is the location of enzymes involved in oxidative phosphorylation?
What is the location of enzymes involved in oxidative phosphorylation?
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What is the main difference between transport vesicles and secretory vesicles?
What is the main difference between transport vesicles and secretory vesicles?
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What is the significance of the presence of DNA, RNA, and ribosomes in mitochondria and chloroplasts?
What is the significance of the presence of DNA, RNA, and ribosomes in mitochondria and chloroplasts?
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What is the main difference between the smooth ER and the rough ER?
What is the main difference between the smooth ER and the rough ER?
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What is a key difference between prokaryotic cells and eukaryotic cells?
What is a key difference between prokaryotic cells and eukaryotic cells?
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Which of the following statements best describes the cell wall of E. coli?
Which of the following statements best describes the cell wall of E. coli?
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Which of the following features is NOT a typical characteristic of eukaryotic cells?
Which of the following features is NOT a typical characteristic of eukaryotic cells?
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What is a primary reason why the evolution of eukaryotic cells from prokaryotes is considered a significant challenge in evolutionary biology?
What is a primary reason why the evolution of eukaryotic cells from prokaryotes is considered a significant challenge in evolutionary biology?
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Which of the following statements best describes the organization of DNA in E. coli?
Which of the following statements best describes the organization of DNA in E. coli?
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What is a key difference between the DNA of eukaryotic cells and the DNA of prokaryotic cells?
What is a key difference between the DNA of eukaryotic cells and the DNA of prokaryotic cells?
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Which of the following statements is FALSE about unicellular eukaryotes?
Which of the following statements is FALSE about unicellular eukaryotes?
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Which of the following best describes the term 'compartmentalization' as it applies to eukaryotic cells?
Which of the following best describes the term 'compartmentalization' as it applies to eukaryotic cells?
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Which of these statements describes the primary function of mitochondria? (Select one)
Which of these statements describes the primary function of mitochondria? (Select one)
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What is the primary evidence supporting the endosymbiotic theory of the origin of mitochondria and chloroplasts? (Select one)
What is the primary evidence supporting the endosymbiotic theory of the origin of mitochondria and chloroplasts? (Select one)
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Which of the following is NOT a key feature of the viral eukaryogenesis hypothesis? (Select one)
Which of the following is NOT a key feature of the viral eukaryogenesis hypothesis? (Select one)
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According to the viral eukaryogenesis hypothesis, which of the following functions remained relatively unchanged after the formation of the nucleus? (Select one)
According to the viral eukaryogenesis hypothesis, which of the following functions remained relatively unchanged after the formation of the nucleus? (Select one)
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What is the evolutionary significance of the development of ATP synthesis? (Select one)
What is the evolutionary significance of the development of ATP synthesis? (Select one)
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Which of the following is NOT a key stage in the evolution of ATP synthesis? (Select one)
Which of the following is NOT a key stage in the evolution of ATP synthesis? (Select one)
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Which of the following statements accurately compares mitochondria and chloroplasts? (Select one)
Which of the following statements accurately compares mitochondria and chloroplasts? (Select one)
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What is the significance of the statement that mitochondria and chloroplasts have their own DNA? (Select one)
What is the significance of the statement that mitochondria and chloroplasts have their own DNA? (Select one)
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According to the viral eukaryogenesis hypothesis, why did the virus evolve into the eukaryotic nucleus? (Select one)
According to the viral eukaryogenesis hypothesis, why did the virus evolve into the eukaryotic nucleus? (Select one)
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Which of the following statements describes the role of the cell in the viral eukaryogenesis hypothesis? (Select one)
Which of the following statements describes the role of the cell in the viral eukaryogenesis hypothesis? (Select one)
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Which of the following scientists is NOT credited with contributing to the development of cellular theory?
Which of the following scientists is NOT credited with contributing to the development of cellular theory?
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Which of the following statements accurately describes the relationship between physiology, cellular physiology, and molecular biology?
Which of the following statements accurately describes the relationship between physiology, cellular physiology, and molecular biology?
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Which of the following elements accounts for the highest percentage of a cell's net weight?
Which of the following elements accounts for the highest percentage of a cell's net weight?
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Which of the following concepts is NOT directly linked to the development of modern medicine?
Which of the following concepts is NOT directly linked to the development of modern medicine?
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What is the approximate empirical formula for a cell, based on the four most abundant elements?
What is the approximate empirical formula for a cell, based on the four most abundant elements?
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Flashcards
Modern Physiology
Modern Physiology
A synthetic academic discipline encompassing multiple areas like classical physiology and molecular biology.
Cell Theory
Cell Theory
All living organisms are composed of cells, established by Schleiden and Schwann in 1838.
Basic Cell Composition
Basic Cell Composition
Cells consist mainly of six elements: C, O, H, N, Ca, and P, which account for 99% of their weight.
Cellular Pathology
Cellular Pathology
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Cellular Pharmacology
Cellular Pharmacology
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Hydrogen atom size
Hydrogen atom size
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DNA diameter
DNA diameter
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Nanoscale behavior
Nanoscale behavior
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Resonance frequency
Resonance frequency
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Eukaryotic cell size
Eukaryotic cell size
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Endoplasmic Reticulum (ER)
Endoplasmic Reticulum (ER)
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Granular ER
Granular ER
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Agranular ER
Agranular ER
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Golgi Apparatus
Golgi Apparatus
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Transport Vesicles
Transport Vesicles
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Mitochondria
Mitochondria
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Chloroplast
Chloroplast
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Endosymbiotic Theory
Endosymbiotic Theory
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E. coli
E. coli
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Prokaryotic cell structure
Prokaryotic cell structure
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Cell wall composition
Cell wall composition
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Plasma membrane
Plasma membrane
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Eukaryotes complexity
Eukaryotes complexity
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Yeasts
Yeasts
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Amoeba proteus
Amoeba proteus
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Evolutionary biology challenge
Evolutionary biology challenge
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Primitive Atmosphere
Primitive Atmosphere
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Miller's Experiment
Miller's Experiment
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Formation of Macromolecules
Formation of Macromolecules
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RNA World Hypothesis
RNA World Hypothesis
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Prokaryotic Evolution
Prokaryotic Evolution
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Archaebacteria
Archaebacteria
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Eubacteria
Eubacteria
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Self-Replication
Self-Replication
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Common Ancestor
Common Ancestor
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Endosymbiosis
Endosymbiosis
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Organelle DNA
Organelle DNA
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Evolution of ATP
Evolution of ATP
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Viral origin hypothesis
Viral origin hypothesis
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Adenosine triphosphate (ATP)
Adenosine triphosphate (ATP)
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Photosynthesis
Photosynthesis
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Oxidative phosphorylation
Oxidative phosphorylation
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Aerobic Bacteria
Aerobic Bacteria
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Study Notes
Modern Physiology
- Physiology is an academic discipline
- Modern physiology is a synthetic discipline, including classical, cellular, and molecular biology
- Physiology, cellular physiology, and pharmacology are closely related
Cell as the Basic Unit of Life
- Evolution of the cell concept:
- 1665: Robert Hooke introduced the concept of the cell
- 1670s: Antoine van Leeuwenhoek made biological observations using a microscope
- 1833: Robert Brown discovered the nucleus
- 1838: Schleiden and Schwann developed the Cell Theory, stating all organisms are composed of cells
- Cellular Theory (1838): marks the beginning of modern biology.
- Cellular Pathology (1848): marks the beginning of modern medicine.
- Cellular Pharmacology (1899): marks the beginning of pharmacology.
Basic Cell Composition
- Cells mainly consist of carbon, oxygen, hydrogen, nitrogen, calcium, and phosphorus.
- These elements make up 99% of cell weight.
- Carbon, hydrogen, oxygen, and nitrogen account for 96%.
- The other 5 elements (sodium, potassium, chlorine, magnesium, and sulfur) amount to 0.85%
- 11 mentioned elements are crucial for life; the remaining elements are trace elements.
Cell Types
- Cells are categorized based on whether they contain a nucleus.
- Prokaryotes: Single-celled organisms without a nucleus (bacteria, 1-5 μm).
- Eukaryotes: Organisms with a nucleus (plants, animals, fungi, algae, protozoa, 10-100 μm). More complex and larger.
- New biological classification divides life into three domains: Bacteria, Archaea, and Eukaryotes.
Surface Area/Volume Ratio
- Surface area/volume ratio is a major constraint of cell size.
- Larger surface area (relative to volume) is crucial for efficient transport and metabolism.
- Cell volume increases faster than surface area.
Homeostasis
- The internal environment must remain relatively constant for independent and functional life
- This is vital for all organ functions across organisms.
- Homeostasis is maintained by organ systems, aiming to maintain stable internal physiology
Cell Volume and Pressure
- Various molecules, from hydrogen to large eukaryotic cells, have dimensions and volumes expressed at the nanometer scale.
Elements of Cellular Evolution: Primitive Atmosphere
- Simple organic molecules emerged from the early Earth’s primitive atmosphere
- These molecules polymerized due to low PO2 in the primitive atmosphere.
- Sun's energy in the form of radiant or electrical energy aided in the formation of organic molecules.
Elements of Cellular Evolution: Formation of Organic Molecules
- Miller's experiments replicated early Earth conditions and demonstrated the spontaneous synthesis of organic molecules.
Elements of Cellular Evolution: Macromolecules and the RNA World
- Monomers polymerize to form macromolecules. This process is driven by prebiotic conditions.
- Nucleic acids (RNA) have unique capabilities for replicating their structures, crucial for self-replication and reproduction.
- RNA molecules are self-replicating catalytic entities crucial for the evolution of life (RNA World Hypothesis).
Evolution of Prokaryotes and Eukaryotes
- Prokaryotic life predates eukaryotic life, lasting approximately 1-1.5 billion years.
- Eukaryotic life evolved significantly later (approximately 2.7 billion years ago).
- Bacteria/Archea are different from each other. The divergence occurred early in the evolution of life.
Elements of Evolution: Prokaryotic Cells
- Present-day prokaryotes fall into two categories: Archaebacteria and Eubacteria.
- Archaebacteria are often adapted to harsh environments.
- Prokaryotic cells are generally smaller and simpler (without internal membrane-bound organelles).
- Prokaryotic cells have less complex genomes.
- All present-day cells, prokaryotes and eukaryotes, originate from a common ancestral cell.
Prokaryotes
- Bacteria are a vast group that inhabit various environments (soil, water, organisms).
- Bacteria have a wide variety of forms (spherical, rod-shaped, spiral), ranging in diameter from 1 to 10 μm.
- Prokaryotes have relatively small genomes (0.6 to 5 million base pairs coding for about 5000 proteins)
- Genetic material is not contained in a membrane-bound nucleus.
Elements of Evolution: Eukaryotic Cells
- The defining feature of eukaryotes is the presence of membrane-bound organelles.
- Eukaryotic cells are larger and more complex, possessing membrane-bound organelles and a cytoskeleton lacking in Prokaryotes.
- Eukaryotic cells have a more extensive compartmentalization compared to prokaryotes.
Yeast as an Example of Eukaryotes
- Yeasts are simple, unicellular eukaryotes. They exhibit self-replication capabilities.
- Yeasts are simpler and smaller than cells in animals and plants.
Amoeba as an Example of Eukaryotes
- Amoeba (one example of a unicellular eukaryote) are complex cells.
- Amoeba exhibit a variety of tasks (photosynthesis, movement) and can ingest other organisms.
- Amoeba are highly mobile organisms using cytoplasmic extension to engulf other organisms.
The Last Eukaryote Common Ancestor (LECA)
- All present-day eukaryotic species arose from a single common ancestor.
- Conservation of many genes throughout eukaryotic evolution suggests the fundamental features of cellular processes arose early in eukaryotic evolution.
- Eukaryotic cells have a more complex and highly organized architecture.
Eukaryotic Cells and the Kinase-Phosphatase Regulatory System
- The complex architecture of eukaryotic cells is supported by advanced signalling mechanisms.
- A critical process are phosphorylation and dephosphorylation reactions, catalyzed by enzymes called kinases and phosphatases, respectively.
Nucleus
- The nucleus is the central organelle of eukaryotic cells, containing genetic material.
- Nucleus is surrounded by a double membrane called the nuclear envelope.
- Nuclear pores allow selective transport between the nucleoplasm (nucleus contents) and the cytoplasm.
Organelles
- Endoplasmic Reticulum (ER): Involved in protein synthesis, lipid synthesis, membrane production, and xenobiotic metabolism.
- Golgi Complex: Processes and packages proteins, sorting for delivery to their final destinations.
- Ribosomes: Sites of protein synthesis.
- Lysosomes and Peroxisomes: Membrane-bound organelles that degrade waste products and molecules.
- Mitochondria: Powerhouse of the cell, producing ATP through cellular respiration.
- Chloroplasts: Organelle responsible for photosynthesis (only in plants).
- Cytoskeletal elements: Provide structural support.
- Nuclear Envelope: Double membrane surrounding the nucleus
- Nuclear Pores: Allow selective transport between the nucleus and cytoplasm.
Mitochondria and Chloroplasts
- Mitochondria and chloroplasts are thought to have arisen through endosymbiosis, involving a symbiotic relationship with bacterial precursors.
- Mitochondria (in most eukaryotes) are sites of oxidative metabolism and ATP production.
- Chloroplasts (found in plant cells) are the site of photosynthesis.
- Both mitochondria and chloroplasts have their own DNA and ribosomes, further supporting their endosymbiotic origin.
Nucleus - Viral Origin Hypothesis
- A hypothesis that suggests the nucleus evolved from a DNA virus.
- According to this hypothesis, the virus gradually acquired genes from the host genome over time and eventually integrated into the host cell structure becoming a nucleus.
Evolution of Metabolism
- Controlled metabolic energy utilization is central to all cellular activity.
- Adenosine triphosphate (ATP) is the primary energy currency for cells.
- Three evolutionary steps are associated with the development of ATP synthesis: glycolysis, photosynthesis, and oxidative phosphorylation.
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Description
Test your knowledge on molecular biology and the characteristics of prokaryotic cells. This quiz covers topics such as the size of biological structures, the early Earth's atmosphere, and significant findings from Miller's experiments. Challenge yourself to understand the relationships and classifications within biology.