Biology Chapter: Metabolism and Nutrition

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Micronutrients

Vitamins and minerals obtained only from diet.

Macronutrients

Carbohydrates, lipids, and proteins, needed in larger quantities.

Carbohydrates

Macronutrients composed of monosaccharides.

Monosaccharides

Simple sugars, the building blocks of carbohydrates.

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Lipids

Macronutrients composed of glycerol and fatty acids.

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Proteins

Macronutrients composed of amino acids, crucial for body structure.

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Amino acids

Building blocks of proteins.

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Glycolysis

Breakdown of glucose into 2 pyruvates.

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Citric Acid Cycle

Pyruvate converted to Acetyl CoA, further energy production.

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Cellular Respiration Waste

Carbon dioxide and water.

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Beta-oxidation

Fatty acid breakdown in mitochondria to generate Acetyl CoA.

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Metabolic Acidosis

Too much acid or too little bicarbonate in the blood.

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Metabolic Alkalosis

Too little acid or too much bicarbonate in the blood.

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Low Blood Sugar

Glucagon signals liver to release glucose (glycogenolysis/gluconeogenesis).

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High Blood Sugar

Insulin helps cells absorb glucose, lowering blood sugar.

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Glucose Metabolism Byproduct

Lactic acid.

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Amino Acid Metabolism Byproduct

Urea, filtered by kidneys.

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Cholesterol

Fatty substance, crucial for cell and hormone production, but excessive levels can lead to health issues.

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LDL Cholesterol

Low-density lipoprotein (bad) cholesterol that carries cholesterol to cells.

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HDL Cholesterol

High-density lipoprotein (good) cholesterol that removes cholesterol from cells.

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Absorptive/Fed State

Period after a meal (approx 4 hours) where insulin is predominant.

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Post-Absorptive State

Period after a meal (6-12 hours) where glucagon is predominant.

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Insulin

Pancreatic hormone that lowers blood sugar.

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Glucagon

Pancreatic hormone that raises blood sugar.

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Thyroxine

Thyroid hormone regulating metabolism, growth, and energy production.

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Catabolism

Breakdown of complex molecules into smaller units.

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What are micronutrients?

Essential nutrients required in small amounts that the body cannot produce on its own. These are vital for various bodily functions and are obtained solely from your diet.

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What are macronutrients?

Nutrients that are needed in large amounts for energy and building blocks for the body. They include carbohydrates, lipids, and proteins.

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What is glycolysis?

The breakdown of glucose (sugar) into pyruvate, a process that occurs in the cytoplasm of cells.

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What is the Citric Acid Cycle?

A series of chemical reactions that occur in the mitochondria, where pyruvate is converted into acetyl-CoA and used to further produce energy.

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What are the main waste products of cellular respiration?

Carbon dioxide and water

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What is beta-oxidation?

The process of breaking down fatty acids into acetyl-CoA in the mitochondria.

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What is metabolic acidosis?

A condition where the blood becomes too acidic (too much acid or too little bicarbonate).

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What is metabolic alkalosis?

A condition where the blood becomes too basic (too little acid or too much bicarbonate).

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How does your body respond to metabolic acidosis?

The body responds by secreting more hydrogen ions (H+) and reabsorbing bicarbonate ions to bring the pH back to normal.

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How does your body respond to metabolic alkalosis?

The body responds by secreting bicarbonate ions and reabsorbing hydrogen ions to bring the pH back to normal.

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What is glucagon?

A hormone produced by the alpha cells of the pancreas that increases blood glucose levels. It signals the liver to release stored glucose and to produce new glucose.

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What is insulin?

A hormone produced by the beta cells of the pancreas that decreases blood glucose levels. It helps cells absorb glucose for energy or storage.

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What are the byproducts of glucose metabolism?

Lactic acid is a byproduct of glucose metabolism.

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What are the byproducts of amino acid metabolism?

Urea is the main byproduct of amino acid metabolism, and it is filtered through the kidneys and excreted in urine.

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What is cholesterol?

A waxy substance found in your body that is essential for building cells and making hormones. However, high levels can increase the risk of heart disease.

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What are the different types of cholesterol?

LDL (low-density lipoprotein) is often called 'bad' cholesterol because it carries cholesterol to cells. HDL (high-density lipoprotein) is often called 'good' cholesterol because it removes excess cholesterol. VLDL (very low-density lipoprotein) is a type of lipid that carries triglycerides.

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What is the absorptive state?

The period after eating, usually lasting about 4 hours, where the body is actively digesting and absorbing nutrients from food. Insulin is the predominant hormone during this state.

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What is the post-absorptive state?

The period after the absorptive state, usually lasting 6-12 hours, where the body is using stored energy as it prepares for the next meal. Glucagon is the predominant hormone during this state.

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Where is thyroxine produced?

Thyroxine (T3 and T4) is produced by the thyroid gland.

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What is catabolism?

The process of breaking down complex molecules into smaller units, often releasing energy in the process.

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What is metabolism?

The sum of all chemical reactions that occur in the body, including both catabolism and anabolism.

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What is basal metabolic rate (BMR)?

The amount of energy your body uses to maintain basic functions while at rest.

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What is metabolic rate?

The total amount of energy your body uses in a given period of time, usually a day.

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What is the difference between BMR and metabolic rate?

BMR represents the energy needed for basic functions at rest, whereas metabolic rate accounts for energy expenditure during activity.

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What is insensible heat loss?

The heat loss through evaporation from the skin, lungs, and oral mucosa that you don't consciously perceive.

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What is spermatogenesis?

The process of producing sperm cells in the testes, starting with germ cells and ending with mature sperm.

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What is spermiogenesis?

The final stage of spermatogenesis where the immature sperm cells (spermatids) transform into mature, motile sperm.

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What is oogenesis?

The process of egg cell production in the ovaries, starting with a germ cell and ending with a mature egg cell.

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What is progesterone?

A hormone produced by the ovaries that plays a crucial role in preparing the body for pregnancy and regulating the menstrual cycle.

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What is estrogen?

A hormone produced by the ovaries that regulates the menstrual cycle, promotes female sexual characteristics, and is essential for pregnancy and bone health.

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What is testosterone?

A hormone primarily produced by the testes that influences male sexual characteristics, libido, and sperm production.

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What is FSH?

A hormone produced by the pituitary gland that stimulates the development of follicles in the ovaries and, in males, stimulates spermatogenesis.

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What is LH?

A hormone produced by the pituitary gland that triggers ovulation in women and stimulates testosterone production in men.

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What is implantation?

The attachment of a fertilized egg to the lining of the uterus (endometrium), where it will develop during pregnancy.

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When is Meiosis II completed during oogenesis?

Meiosis II is not completed until fertilization.

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What is the follicular phase of the ovarian cycle?

The first phase of the menstrual cycle, where follicles in the ovaries grow and produce estrogen. It typically lasts from days 1-14.

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What is ovulation?

The release of a mature egg from the ovary into the fallopian tube. It is triggered by a surge in LH.

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What is the luteal phase of the ovarian cycle?

The phase after ovulation, where the empty follicle transforms into the corpus luteum and secretes progesterone and estrogen. It always lasts 14 days.

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What is a primordial follicle?

The earliest stage of follicle development. These follicles contain a primary oocyte and are present at birth.

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What is a primary follicle?

The next stage of follicle development, where the oocyte enlarges and FSH starts to act on the follicle.

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What is a secondary follicle?

The next stage of follicle development, where the follicle continues to grow and cells start producing androgens, which are converted into estrogen. Follicular fluid also begins to accumulate.

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What is a tertiary follicle?

The next stage of follicle development, where a fluid-filled cavity called the antrum develops, and estrogen production increases.

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What is a mature follicle?

The final stage of follicle development, where the antrum enlarges and the follicle is ready for ovulation. The oocyte completes meiosis I and starts meiosis II.

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What is the end result of spermiogenesis?

Spermiogenesis produces mature sperm containing a head, acrosome, midpiece, and tail.

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What is the difference between spermatogonia and oogonia?

Spermatogonia can continuously produce sperm, resulting in four sperm per primary spermatocyte. Oogonia are limited in number and produce one egg per primary oocyte, with the rest becoming polar bodies.

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When do we see hormone surges?

LH surge triggers ovulation. FSH surge stimulates follicle growth. Estrogen surge signals the pituitary to release LH surge. Progesterone surge maintains the uterine lining.

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What is a secondary oocyte?

A haploid cell formed during oogenesis. It is released during ovulation and capable of being fertilized. Meiosis II is only completed upon fertilization.

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What is the endometrial cycle?

Changes in the endometrium (uterine lining) in response to hormone fluctuations during the menstrual cycle.

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Study Notes

Micronutrients

  • Vitamins and minerals
  • Obtained only from diet

Macronutrients

  • Carbohydrates (monosaccharides)
  • Lipids (glycerol/fatty acids)
  • Proteins (amino acids)

Glycolysis

  • Glucose broken down into 2 pyruvate

Citric Acid Cycle

  • Each pyruvate converted into 1 Acetyl CoA

Cellular Respiration Waste Products

  • Carbon dioxide (CO2)
  • Water (H2O)

Beta-oxidation of Fatty Acids

  • Fatty acids broken down in mitochondria
  • Acetyl-CoA enters citric acid cycle for energy production

Metabolic Acidosis

  • Too much acid or too little bicarbonate in the blood
  • Body secretes H+, reabsorbs bicarbonate

Metabolic Alkalosis

  • Too little acid or too much bicarbonate in the blood
  • Body secretes bicarbonate, and reabsorbs H+ ions

Low Blood Sugar

  • Glucagon signals the liver to release stored glucose (glycogenolysis) and produce new glucose (gluconeogenesis)

High Blood Sugar

  • Insulin helps cells absorb glucose for energy storage, lowering blood sugar levels

Byproducts of Glucose Metabolism

  • Lactic acid

Byproducts of Amino Acid Metabolism

  • Urea
  • Filtered through kidneys

Cholesterol

  • Fatty substance in the body
  • Aids in cell building and hormone production
  • High levels can cause health problems like heart disease
  • Produced in the liver
  • Cholesterol component of steroid hormones, bile salts, and vitamin D

Absorptive/Fed State

  • 4 hours
  • Insulin is the dominant hormone
  • Hyperglycemic state
  • Stores excess glucose for later use

Post Absorptive State

  • 6-12 hours
  • Glucagon is the dominant hormone
  • Hypoglycemic state

Insulin

  • Produced by beta cells of the pancreas
  • Lowers blood sugar levels

Glucagon

  • Produced by alpha cells of the pancreas
  • Raises blood sugar levels

Thyroxine

  • Produced by the thyroid
  • T3 and T4 regulate metabolism, energy, production, and growth

Catabolism

  • Breaking down complex molecules into smaller units

Metabolism

  • Sum of all chemical reactions in a cell (catabolism + anabolism)

Basal Metabolic Rate

  • Amount of energy body uses for basic functions at rest

Metabolic Rate

  • Amount of energy used in a given period (often a day)

Spermatogenesis

  • Process of sperm production
  • 4 sperm cells produced from each primary spermatocyte

Spermiogenesis

  • Final stage of spermatogenesis
  • Changes in immature sperm cells to form mature, motile sperm
  • 4 sperm produced from each primary spermatocyte

Oogenesis

  • Process of egg (ova) production in females
  • 1 egg produced from each primary oocyte

Progesterone

  • Prepares body for pregnancy
  • Regulates menstrual cycle

Estrogen

  • Regulates menstrual cycle
  • Promotes female sexual characteristics
  • Crucial for pregnancy and bone health

Testosterone

  • Influences male sexual characteristics, libido, and sperm production
  • High initial levels signify puberty
  • Promotes muscle, growth, strength, and recovery

FSH

  • Helps ovaries prepare eggs for ovulation
  • Stimulates follicle development to produce estrogen

LH

  • Triggers ovulation in ovaries
  • Stimulates testosterone production in testes

Ovarian Cycle

  • Follicular phase, ovulation, luteal phase

Menstrual Cycle

  • Proliferative phase, secretory phase (if pregnancy), and ischemic phase (if no pregnancy)

EXTRA CREDIT

  • Tachycardia: abnormally fast heart rate
  • Bradycardia: abnormally slow heart rate
  • Ventricular fibrillation: disorganized rapid electrical activity in ventricles
  • Heart sounds (Lub-dub): closing of heart valves (S1 and S2)
  • P wave: atrial depolarization

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