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Questions and Answers
What percentage of a human's mass is approximately carbon?
What percentage of a human's mass is approximately carbon?
- 18.5% (correct)
- 25.0%
- 12.5%
- 30.0%
Which chemical element has the strongest tendency to attract electrons based on electronegativity?
Which chemical element has the strongest tendency to attract electrons based on electronegativity?
- Nitrogen
- Carbon
- Sulfur
- Oxygen (correct)
Which type of bond involves the sharing of electron pairs between atoms?
Which type of bond involves the sharing of electron pairs between atoms?
- Van der Waals interactions
- Ionic bonds
- Hydrogen bonds
- Covalent bonds (correct)
What type of noncovalent interaction occurs between a charged group on one molecule and an oppositely charged group on another molecule?
What type of noncovalent interaction occurs between a charged group on one molecule and an oppositely charged group on another molecule?
Which interaction is largely associated with the attraction of a partially positively charged hydrogen atom to a partially negatively charged atom?
Which interaction is largely associated with the attraction of a partially positively charged hydrogen atom to a partially negatively charged atom?
Which arrangement minimizes electron pair repulsion in hydrogen bonding?
Which arrangement minimizes electron pair repulsion in hydrogen bonding?
What element is least likely to have a significant role in forming biological compounds based on covalent bonding?
What element is least likely to have a significant role in forming biological compounds based on covalent bonding?
The stability of hydrogen bonds can be enhanced by which of the following factors?
The stability of hydrogen bonds can be enhanced by which of the following factors?
Which of the following interactions is weakest among noncovalent interactions?
Which of the following interactions is weakest among noncovalent interactions?
What structural feature gives rise to resonance structures?
What structural feature gives rise to resonance structures?
Which type of interaction is primarily responsible for the attractive forces between water molecules?
Which type of interaction is primarily responsible for the attractive forces between water molecules?
What characterizes Van der Waals interactions?
What characterizes Van der Waals interactions?
What happens to the pH when strong acids are added to a solution?
What happens to the pH when strong acids are added to a solution?
Which of the following interactions involves the formation of water molecule 'cages'?
Which of the following interactions involves the formation of water molecule 'cages'?
How can the concentration of an acid and its conjugate base be described when pH is equal to pKa?
How can the concentration of an acid and its conjugate base be described when pH is equal to pKa?
Which type of interaction is considered the weakest according to the strength hierarchy?
Which type of interaction is considered the weakest according to the strength hierarchy?
How would the dielectric constant of water be described?
How would the dielectric constant of water be described?
What effect does increasing hydrogen ion concentration have on pH?
What effect does increasing hydrogen ion concentration have on pH?
What separates a dipole within a molecule?
What separates a dipole within a molecule?
What role do nonpolar molecules play in aqueous solutions?
What role do nonpolar molecules play in aqueous solutions?
What is indicated by a pH that is smaller than the pKa value of a weak acid?
What is indicated by a pH that is smaller than the pKa value of a weak acid?
Which statement about weak acids and weak bases functioning as buffers is true?
Which statement about weak acids and weak bases functioning as buffers is true?
What occurs to bicarbonate concentration when carbon dioxide removal is increased during ventilation?
What occurs to bicarbonate concentration when carbon dioxide removal is increased during ventilation?
Why do strong acids and bases form poor buffers?
Why do strong acids and bases form poor buffers?
What is the primary function of a buffer system involving carbonic acid (H2CO3) and bicarbonate anion (HCO3-)?
What is the primary function of a buffer system involving carbonic acid (H2CO3) and bicarbonate anion (HCO3-)?
When considering buffer systems, what occurs if there is an excess of hydrogen ions (H+) in the solution?
When considering buffer systems, what occurs if there is an excess of hydrogen ions (H+) in the solution?
Which amino acid is represented as a diprotic acid with more than one dissociable hydrogen ion?
Which amino acid is represented as a diprotic acid with more than one dissociable hydrogen ion?
The dynamic equilibrium of a buffer system allows which of the following?
The dynamic equilibrium of a buffer system allows which of the following?
What happens if the concentration of hydroxide ions (OH-) increases significantly in a buffered solution?
What happens if the concentration of hydroxide ions (OH-) increases significantly in a buffered solution?
How does hyperventilation affect the balance of bicarbonate in the blood?
How does hyperventilation affect the balance of bicarbonate in the blood?
What is the primary role of the carbonic acid-bicarbonate buffer in the blood?
What is the primary role of the carbonic acid-bicarbonate buffer in the blood?
According to the Le Bel–Van 't Hoff rule, how many stereoisomers can a compound with 3 asymmetric carbon atoms have?
According to the Le Bel–Van 't Hoff rule, how many stereoisomers can a compound with 3 asymmetric carbon atoms have?
Which statement correctly summarizes the concept of entropy in living systems?
Which statement correctly summarizes the concept of entropy in living systems?
What stabilizes the tertiary structure of proteins?
What stabilizes the tertiary structure of proteins?
Which of these statements is true regarding myoglobin?
Which of these statements is true regarding myoglobin?
Which of the following describes the quaternary structure of proteins?
Which of the following describes the quaternary structure of proteins?
In the context of thermodynamics, what does enthalpy refer to?
In the context of thermodynamics, what does enthalpy refer to?
Which type of amino acids carries a positive charge?
Which type of amino acids carries a positive charge?
What is the main factor that governs the stability of the carbonic acid-bicarbonate buffer system?
What is the main factor that governs the stability of the carbonic acid-bicarbonate buffer system?
Which of the following statements about isomers is correct?
Which of the following statements about isomers is correct?
Flashcards
Biochemistry
Biochemistry
The study of chemical processes happening in living organisms.
Covalent Bond
Covalent Bond
A chemical bond formed by the sharing of electron pairs between atoms.
Resonance Structures
Resonance Structures
Different ways of representing the same molecule that differ only in electron distribution.
Electronegativity
Electronegativity
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Hydrogen Bond
Hydrogen Bond
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Noncovalent Interactions
Noncovalent Interactions
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Ionic Interactions
Ionic Interactions
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van der Waals Interactions
van der Waals Interactions
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Biological Compounds
Biological Compounds
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Importance of Carbon
Importance of Carbon
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Van der Waals Interactions
Van der Waals Interactions
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Dipole
Dipole
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Hydrogen Bonds
Hydrogen Bonds
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Hydrophobic Interactions
Hydrophobic Interactions
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Water as a Solvent
Water as a Solvent
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Water Cohesion
Water Cohesion
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Acid
Acid
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Base
Base
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pH
pH
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pKa
pKa
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Titration curve
Titration curve
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pKa
pKa
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Weak Acid
Weak Acid
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Buffer
Buffer
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Polyprotic Acid
Polyprotic Acid
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Base
Base
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Bicarbonate in ventilation
Bicarbonate in ventilation
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Blood Buffer
Blood Buffer
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Strong Acid/Base Buffering
Strong Acid/Base Buffering
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Amino Acid
Amino Acid
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pH regulation in body
pH regulation in body
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Carbonic acid-bicarbonate buffer
Carbonic acid-bicarbonate buffer
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pKa of carbonic acid
pKa of carbonic acid
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Stereoisomers
Stereoisomers
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Asymmetric carbon atoms
Asymmetric carbon atoms
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Le Bel–Van 't Hoff rule
Le Bel–Van 't Hoff rule
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Protein composition and structure
Protein composition and structure
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Myoglobin
Myoglobin
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Protein Structure (Tertiary)
Protein Structure (Tertiary)
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Protein Structure (Quaternary)
Protein Structure (Quaternary)
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Study Notes
Biochemistry of Life Processes
- Life on Earth is carbon-based
- 18.5% of human mass is carbon
- Key elements in biological compounds: C, H, O, N, P, S
Covalent Bonds
- Strongest bonds
- Involve electron pair sharing between atoms
Electronegativity
- Property describing an atom's electron attraction
- Trend: O > N > S > C > P > H
Resonance Structures
- Double bonds cause resonance structures
- Not static bonds
Noncovalent Interactions
- Ionic Interactions: Oppositely charged groups attract
- Hydrogen Bonds: Partially positive hydrogen atoms attract partially negative acceptor atoms
- 180° angle in hydrogen bonds minimizes electron pair repulsion, optimizes interaction and increases stability
- Van der Waals Interactions: Weak, temporary attractive forces between molecules
Molecules in Aqueous Solutions
- Interact with water through hydrogen bonding and ionic interactions
- Water is a versatile solvent, especially for polar and charged compounds
Water (Hâ‚‚O)
- Highly cohesive due to strong hydrogen bonding
- High dielectric constant (80)
Acids and Bases
- Acids: Proton donors
- Bases: Proton acceptors
- pH = -log[H+]
- Buffers help maintain stable pH
Amino Acids
- Peptide Bond Formation: Forms between amino acids
- Hydrophobic Amino Acids: (e.g. Glycine, Alanine, Valine - hydrophobic, less attraction to water molecules)
- Polar Amino Acids: (e.g. Serine, Threonine, Tyrosine - polar, more attraction to water molecules)
- Positively charged: (e.g., Arginine, Histidine, Lysine)
- Negatively charged: (e.g. Aspartate, Glutamate)
Stereoisomers
- Different spatial arrangement of atoms
- Le Bel-Van 't Hoff rule (2n)
Living Systems and Disorder
- Entropy: Measure of disorder in a system
- Enthalpy: Total heat content in a process
- 2nd law of thermodynamics: Natural processes tend to increase disorder
Proteins
- Primary Structure: Amino acid sequence
- Secondary Structure: Hydrogen bonding patterns (alpha helix, beta sheet)
- Tertiary Structure: 3D folding of a protein
- Quaternary Structure: Multiple polypeptide chains
Myoglobin and Hemoglobin
- Myoglobin: Heme protein for oxygen storage, single polypeptide chain
- Hemoglobin: Heme protein for oxygen transport, 4 polypeptide chains (2 alpha, 2 beta)
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