Biochemistry MCQ
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Questions and Answers

Which enzyme is responsible for hydrolyzing alpha(1-6) glycosidic branching bonds of glycogen molecules?

  • Glycogen phosphorilase
  • Phosphatase
  • Debranching enzyme
  • Glucosidase (correct)
  • Which type of iron is easily absorbed by the body?

  • Non-heme bound iron Fe 2+ (correct)
  • Heme bound iron Fe 3+
  • Non-heme bound iron Fe 3+
  • Heme bound iron Fe 2+
  • In purine biosynthesis, which amino acid contributes carbon atoms at 4 and 5 positions and N at 7 position?

  • Threonine
  • Alanine
  • Glutamine (correct)
  • Glycine
  • What is the main characteristic of the disease Multiple sclerosis?

    <p>Demyelination of nerves</p> Signup and view all the answers

    What is the end product of the reaction catalyzed by the enzyme thymidylate synthase?

    <p>TMP</p> Signup and view all the answers

    Which tissue is not capable of using ketone bodies as an energy source?

    <p>RBC</p> Signup and view all the answers

    Amylase activity increases in the presence of which substance?

    <p>Water</p> Signup and view all the answers

    Which enzyme is involved in galactose metabolism?

    <p>UDP-Galactose 4- epimerase</p> Signup and view all the answers

    Which protein is required for de novo synthesis of glycogen?

    <p>Glycogenin</p> Signup and view all the answers

    Which of the following correctly describes the normal metabolism of bilirubin?

    <p>Bilirubin is produced by the breakdown of heme, is transported to and conjugated in the liver, and is then secreted with other bile components into the small intestine</p> Signup and view all the answers

    What is the primary source of blood glucose during a fasting state?

    <p>Hepatic glycogenolysis</p> Signup and view all the answers

    The FADH2 and NADH2 produced by the oxidation of one acetyl-CoA result in the synthesis of about how many ATPs?

    <p>11</p> Signup and view all the answers

    Which of the following statements concerning glucose metabolism is correct?

    <p>An elevated level of insulin leads to a decreased level of fructose 2,6-biphsophate in hepatocyte</p> Signup and view all the answers

    Where is wall lipoprotein lipase immobilized on the surface of membranes?

    <p>Heparin foot</p> Signup and view all the answers

    What is the first product in porphyrin biosynthesis in eucaryotes?

    <p>Aminolevulinic acid</p> Signup and view all the answers

    Which of the following is NOT a product of the breakdown of heme?

    <p>Aminolevulinic acid</p> Signup and view all the answers

    Study Notes

    Glycogen Metabolism

    • Glycogen branching enzyme hydrolyzes alpha(1-6) glycosidic branching bond of glycogen molecules.
    • Glycogen phosphorylase is an enzyme responsible for glycogenolysis.

    Iron Absorption

    • Non-heme bound iron Fe2+ is easily absorbed.

    Purine Biosynthesis

    • Carbon atoms at 4 and 5 positions and N at 7 position are contributed by glycine.
    • Glutamine contributes to purine biosynthesis.

    Demyelination

    • Multiple sclerosis is characterized by demyelination of nerves.

    Nucleotide Metabolism

    • d-UMP is converted to TMP by methylation.
    • Pyrimidine biosynthesis begins with the formation of dihydroorotate from glutamine, ATP, and CO2.

    Ketone Bodies

    • All tissues, except RBC, can use ketone bodies.
    • Cardiac muscle, brain, and renal cortex can use ketone bodies.

    Enzyme Activity

    • Amylase activity increases under the action of sodium chloride.

    Gout

    • Gout is characterized by increased plasma levels of uric acid.

    Metabolic Pathways

    • Reactions involved in the synthesis of ketone bodies are presented.

    Galactose Metabolism

    • UDP-Galactose 4-epimerase, galactose-1-phosphate uridyl transferase, and galactokinase are enzymes involved in galactose metabolism.

    Enzyme Specificity

    • Enzymes can be specific with respect to optical activity of the product formed, structure of the substrate, and type of reaction.

    Glycogen Synthesis

    • Hepatic glycogenolysis is a primary source of blood glucose during fasting state.
    • Glycogenin is required for de novo synthesis of glycogen.

    Pyrimidine Ring

    • The two nitrogen atoms of the pyrimidine ring are contributed by aspartate and ammonia.

    Bilirubin Metabolism

    • Bilirubin is produced by the breakdown of heme, is transported to and conjugated in the liver, and is then secreted with other bile components into the small intestine.

    ATP Synthesis

    • The FADH2 and NADH2 produced by the oxidation of one acetyl-CoA result in the synthesis of about 11 ATPs.

    Glucose Metabolism

    • Pyruvate kinase catalyses an irreversible reaction.
    • An elevated level of insulin leads to a decreased level of fructose 2,6-biphosphate in hepatocytes.

    Lipoprotein Lipase

    • Lipoprotein lipase is immobilized on the surface of membranes by heparin foot.

    Porphyrin Biosynthesis

    • Aminolevulinic acid, the first product in porphyrin biosynthesis in eucaryotes, is synthesized from succinyl CoA and glycine.

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    Test your knowledge of biochemistry with these multiple-choice questions. Topics include enzyme functions, iron absorption, and purine biosynthesis.

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