10 Questions
Which enzyme catalyzes the formation of carbamoyl phosphate for urea synthesis, using NH4+?
Carbamoyl phosphate synthetase II
What is the reference level of urea in the blood plasma?
2.5-8.3 mM
Where is urea produced?
Liver
What is the main α-ketoacid that serves as an NH2 group acceptor during transamination to form glutamate?
α-ketoglutarate
What is the role of glutamine in the synthesis of carbamoyl phosphate?
Providing nitrogen for pyrimidine biosynthesis
Which of the following is NOT a source of ammonium for the urea cycle?
Glutamine synthetase
What happens when the concentration of ammonia in the blood exceeds 400 μM?
Neurotoxicity
Which of the following represents the conversion of free ammonia into a nontoxic transport form?
Ammonia + Glutamate → Glutamine
What is the main role of the urea cycle in ammonia detoxification?
Converting ammonia into urea for excretion
Which enzyme catalyzes the conversion of glutamine to glutamate in the process of ammonia detoxification?
Glutaminase
Test your knowledge on the detoxification of ammonia, the urea cycle, and the catabolism of the carbon skeletons of amino acids in biochemistry. This quiz covers topics such as the metabolism of Phe, Tyr, and Met, the role of folic acid, biosynthesis of creatine and phosphocreatine, and biosynthesis of nonessential amino acids.
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