Biochemistry: Ammonia Detoxification and Urea Cycle Quiz
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Questions and Answers

Which enzyme catalyzes the formation of carbamoyl phosphate for urea synthesis, using NH4+?

  • Argininosuccinate lyase
  • Ornithine transcarbamoylase
  • Argininosuccinate synthetase
  • Carbamoyl phosphate synthetase II (correct)

What is the reference level of urea in the blood plasma?

  • 10-15 mM
  • 20-30 mM (correct)
  • 5-9 mM
  • 1-3 mM

Which amino acid stimulates the synthesis of N-acetylglutamate, which activates carbamoyl phosphate synthetase I in the short-term regulation of the urea cycle?

  • Arginine (correct)
  • Aspartate
  • Alanine
  • Glutamine

Where does the cycle of urea production begin?

<p>Mitochondria (C)</p> Signup and view all the answers

What is the role of ammonium salts in the urine?

<p>To neutralize NH3 in the renal tubules (C)</p> Signup and view all the answers

What is the primary role of the urea cycle?

<p>To detoxify ammonia by converting it to urea (C)</p> Signup and view all the answers

What is the main source of ammonium for the urea cycle?

<p>Glutamine and asparagine (C)</p> Signup and view all the answers

What is the consequence of high levels of ammonia in the blood?

<p>Metabolic alkalosis and neurotoxicity (B)</p> Signup and view all the answers

Why is free ammonia not directly transported from peripheral tissues to the liver?

<p>Because free ammonia is converted to a nontoxic transport form - glutamine (C)</p> Signup and view all the answers

What role does the urea cycle play in ammonia detoxification?

<p>It converts ammonia to a less toxic form - urea (D)</p> Signup and view all the answers

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