Biochemistry: Ammonia Detoxification and Urea Cycle Quiz
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Questions and Answers

Which enzyme catalyzes the formation of carbamoyl phosphate for urea synthesis, using NH4+?

  • Argininosuccinate lyase
  • Ornithine transcarbamoylase
  • Argininosuccinate synthetase
  • Carbamoyl phosphate synthetase II (correct)
  • What is the reference level of urea in the blood plasma?

  • 10-15 mM
  • 20-30 mM (correct)
  • 5-9 mM
  • 1-3 mM
  • Which amino acid stimulates the synthesis of N-acetylglutamate, which activates carbamoyl phosphate synthetase I in the short-term regulation of the urea cycle?

  • Arginine (correct)
  • Aspartate
  • Alanine
  • Glutamine
  • Where does the cycle of urea production begin?

    <p>Mitochondria</p> Signup and view all the answers

    What is the role of ammonium salts in the urine?

    <p>To neutralize NH3 in the renal tubules</p> Signup and view all the answers

    What is the primary role of the urea cycle?

    <p>To detoxify ammonia by converting it to urea</p> Signup and view all the answers

    What is the main source of ammonium for the urea cycle?

    <p>Glutamine and asparagine</p> Signup and view all the answers

    What is the consequence of high levels of ammonia in the blood?

    <p>Metabolic alkalosis and neurotoxicity</p> Signup and view all the answers

    Why is free ammonia not directly transported from peripheral tissues to the liver?

    <p>Because free ammonia is converted to a nontoxic transport form - glutamine</p> Signup and view all the answers

    What role does the urea cycle play in ammonia detoxification?

    <p>It converts ammonia to a less toxic form - urea</p> Signup and view all the answers

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