Podcast
Questions and Answers
Which receptor is activated by epinephrine to stimulate liver phosphorylase kinase?
Which receptor is activated by epinephrine to stimulate liver phosphorylase kinase?
- α-adrenergic receptor (correct)
- δ-adrenergic receptor
- γ-adrenergic receptor
- β-adrenergic receptor
What is the role of phospholipids in the activation of liver phosphorylase kinase?
What is the role of phospholipids in the activation of liver phosphorylase kinase?
- They bind to calmodulin to activate the kinase
- They activate the kinase directly
- They result in the movement of Ca2+ from the cytoplasm to the ER
- They result in the movement of Ca2+ from the ER into the cytoplasm (correct)
Which protein is responsible for binding to Ca2+ and activating muscle phosphorylase kinase?
Which protein is responsible for binding to Ca2+ and activating muscle phosphorylase kinase?
- Phospholipid
- G protein
- PKA
- Calmodulin (correct)
What triggers the release of acetylcholine at a neuromuscular junction to activate muscle phosphorylase kinase?
What triggers the release of acetylcholine at a neuromuscular junction to activate muscle phosphorylase kinase?
What is the mechanism of activation for muscle phosphorylase kinase?
What is the mechanism of activation for muscle phosphorylase kinase?
Which of the following is not required for the activation of muscle phosphorylase kinase?
Which of the following is not required for the activation of muscle phosphorylase kinase?
What is the role of PKA in the activation of liver phosphorylase kinase?
What is the role of PKA in the activation of liver phosphorylase kinase?
Which of the following is activated by Ca2+-calmodulin complex?
Which of the following is activated by Ca2+-calmodulin complex?
Which of the following is not involved in the activation of muscle phosphorylase kinase?
Which of the following is not involved in the activation of muscle phosphorylase kinase?
Which of the following is not a result of the activation of liver phosphorylase kinase?
Which of the following is not a result of the activation of liver phosphorylase kinase?
Which receptor is activated by epinephrine to stimulate liver phosphorylase kinase?
Which receptor is activated by epinephrine to stimulate liver phosphorylase kinase?
What is the role of phospholipids in the activation of liver phosphorylase kinase?
What is the role of phospholipids in the activation of liver phosphorylase kinase?
Which protein is responsible for binding to Ca2+ and activating muscle phosphorylase kinase?
Which protein is responsible for binding to Ca2+ and activating muscle phosphorylase kinase?
What triggers the release of acetylcholine at a neuromuscular junction to activate muscle phosphorylase kinase?
What triggers the release of acetylcholine at a neuromuscular junction to activate muscle phosphorylase kinase?
What is the mechanism of activation for muscle phosphorylase kinase?
What is the mechanism of activation for muscle phosphorylase kinase?
Which of the following is not required for the activation of muscle phosphorylase kinase?
Which of the following is not required for the activation of muscle phosphorylase kinase?
What is the role of PKA in the activation of liver phosphorylase kinase?
What is the role of PKA in the activation of liver phosphorylase kinase?
Which of the following is not activated by Ca2+-calmodulin complex?
Which of the following is not activated by Ca2+-calmodulin complex?
Which of the following is not involved in the activation of muscle phosphorylase kinase?
Which of the following is not involved in the activation of muscle phosphorylase kinase?
Which of the following is not a result of the activation of liver phosphorylase kinase?
Which of the following is not a result of the activation of liver phosphorylase kinase?
Which molecule is responsible for the activation of liver phosphorylase kinase?
Which molecule is responsible for the activation of liver phosphorylase kinase?
What is the role of acetylcholine in the activation of muscle phosphorylase kinase?
What is the role of acetylcholine in the activation of muscle phosphorylase kinase?
What is the difference between the activation of liver and muscle phosphorylase kinase?
What is the difference between the activation of liver and muscle phosphorylase kinase?
What is the function of phosphorylase kinase?
What is the function of phosphorylase kinase?
How does Ca2+ activate muscle phosphorylase kinase?
How does Ca2+ activate muscle phosphorylase kinase?
What is the source of Ca2+ for the activation of liver phosphorylase kinase?
What is the source of Ca2+ for the activation of liver phosphorylase kinase?
What is the role of calmodulin in the activation of muscle phosphorylase kinase?
What is the role of calmodulin in the activation of muscle phosphorylase kinase?
What is the role of PKA in the activation of muscle phosphorylase kinase?
What is the role of PKA in the activation of muscle phosphorylase kinase?
What is the end result of the activation of phosphorylase kinase?
What is the end result of the activation of phosphorylase kinase?
What is the difference between the activation of liver and muscle phosphorylase kinase in terms of the need for phosphorylation?
What is the difference between the activation of liver and muscle phosphorylase kinase in terms of the need for phosphorylation?
Flashcards
Epinephrine effect on liver
Epinephrine effect on liver
Activates α-adrenergic receptor
Phospholipids role
Phospholipids role
Results in Ca2+ movement from ER to cytoplasm
Calmodulin's role
Calmodulin's role
Binds Ca2+ and activates muscle phosphorylase kinase
Acetylcholine's trigger
Acetylcholine's trigger
Release of Ca2+ from the sarcoplasmic reticulum
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Muscle phosphorylase kinase activation
Muscle phosphorylase kinase activation
Binding of Ca2+-calmodulin complex
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Not required for muscle phosphorylase kinase
Not required for muscle phosphorylase kinase
Phosphorylation by PKA
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PKA's liver role
PKA's liver role
Not involved in the activation of liver phosphorylase kinase
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Activated by Ca2+-calmodulin
Activated by Ca2+-calmodulin
Muscle phosphorylase kinase
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Not involved in muscle phosphorylase
Not involved in muscle phosphorylase
PKA is not involved
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Not a Liver phosphorylase kinase result
Not a Liver phosphorylase kinase result
Increase in insulin secretion
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Epinephrine activates which Receptor?
Epinephrine activates which Receptor?
Alpha-adrenergic receptor
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Phospholipids cause?
Phospholipids cause?
Movement of Ca2+ from the ER into the cytoplasm
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Which protein binds to Calcium?
Which protein binds to Calcium?
Calmodulin
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Acetylcholine triggers release of
Acetylcholine triggers release of
Release of Ca2+ from the sarcoplasmic reticulum
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Muscle phosphorylase kinase mechanism
Muscle phosphorylase kinase mechanism
Binding of Ca2+-calmodulin complex
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Not required for muscle phosphorylase kinase?
Not required for muscle phosphorylase kinase?
Phosphorylation by PKA
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PKA role in the activation of Liver phosphorylase kinase?
PKA role in the activation of Liver phosphorylase kinase?
It is not involved in the activation of liver phosphorylase kinase
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Not activated by Ca2+ calmodulin complex
Not activated by Ca2+ calmodulin complex
PKA is not one
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Not involved in the activation of muscle
Not involved in the activation of muscle
PKA
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Not a result of the activation of liver
Not a result of the activation of liver
Increase in insulin secretion
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Responsible molecule
Responsible molecule
Epinephrine
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What does acetylcholine do here?
What does acetylcholine do here?
Binds to sarcoplasmic Ca2+
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Liver vs. Muscle activation
Liver vs. Muscle activation
Liver phosphorylase kinase is activated by acetylcholine, while muscle phosphorylase kinase is activated by epinephrine
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Function of phosphorylase kinase
Function of phosphorylase kinase
Activates glycogen phosphorylase
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Calcium activation
Calcium activation
Binds to calmodulin
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Source of Calcium
Source of Calcium
Endoplasmic reticulum
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Role of calmodulin
Role of calmodulin
Activates the kinase
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Activation of PKA
Activation of PKA
Phosphorylates that kinase
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End result
End result
Breakdown of glycogen
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Difference between liver and muscle
Difference between liver and muscle
Liver phosphorylase kinase needs to be phosphorylated by PKA, while muscle phosphorylase kinase does not
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