Beta-Lactam Antibiotics: Pharmacology and Therapeutics
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Questions and Answers

What is the action of β-lactam antibiotics on bacteria?

  • They dissolve cell wall structures, leading to rupture and death (correct)
  • They interfere with cell membrane integrity
  • They inhibit DNA replication
  • They prevent protein synthesis

Where are β-lactam antibiotics primarily excreted?

  • In the feces
  • In the urine (correct)
  • In the breath
  • In the sweat

What is the drug of choice for the initial treatment of infections in horses and cattle?

  • Vancomycin
  • Penicillin (correct)
  • Erythromycin
  • Tetracycline

What does '1 unit' of penicillin represent?

<p>Amount of Na penicillin that gave a standard zone of inhibition on a standard culture medium (B)</p> Signup and view all the answers

Why are some penicillins dosed based on units or IU?

<p>The amount of drug needed to produce the desired effect varies (A)</p> Signup and view all the answers

What is the target of β-lactam antibiotics?

<p>Growing &amp; metabolically active bacteria (C)</p> Signup and view all the answers

Where are a significant portion of β-lactam antibiotics metabolized?

<p>Liver (A)</p> Signup and view all the answers

What does '1 unit' of penicillin represent?

<p>Amount of Na penicillin that gave a standard zone of inhibition on a standard culture medium (C)</p> Signup and view all the answers

When did penicillin come into clinical use?

<p>1940s (C)</p> Signup and view all the answers

'Pencillin G' is the drug of choice for the initial treatment of infections in which animals?

<p>Horses and cattle (A)</p> Signup and view all the answers

Flashcards

β-lactam antibiotics action

Dissolve bacterial cell wall structures, causing rupture and death.

β-lactam excretion

Primarily through urine.

Initial horse/cattle treatment

Penicillin.

Penicillin unit (IU)

Amount of penicillin causing a standard inhibition zone.

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Penicillin dosing units reason

Dosage varies based on required effect.

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β-lactam target

Growing and metabolically active bacteria.

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β-lactam metabolism location

Mostly in the liver.

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Penicillin unit definition

Amount of penicillin producing a standard zone of inhibition.

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Penicillin clinical use

1940s.

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Best penicillin for horses/cattle

Penicillin G

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