Beta Blockers for Migraine Prevention
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Questions and Answers

What is the maximum daily dose of propranolol in adults?

  • 240 mg (correct)
  • 120 mg
  • 200 mg
  • 160 mg
  • Which beta blocker has a level A recommendation for effectiveness in migraine prevention?

  • Pindolol
  • Atenolol
  • Nebivolol
  • Propranolol (correct)
  • What is the suggested starting dose range for propranolol in adults?

  • 20-40 mg/day
  • 60-80 mg/day (correct)
  • 40-60 mg/day
  • 80-100 mg/day
  • Which patient group should beta blockers be used cautiously in due to potential limitations?

    <p>Patients with asthma</p> Signup and view all the answers

    What is the general timeline suggested for maintaining the dose of beta blockers before deeming the medication a failure?

    <p>3 months</p> Signup and view all the answers

    What is the proposed mechanism of action of beta blockers in migraine prevention?

    <p>Affecting the central catecholaminergic system and brain serotonin receptors</p> Signup and view all the answers

    What is the maximum recommended dose for propranolol in pediatric patients?

    <p>0.5 to 1 mg/kg/d</p> Signup and view all the answers

    Which symptom suggests that the maximum dosage of a medication has been reached in adults?

    <p>Pulse below 50</p> Signup and view all the answers

    Why should pediatric patients be monitored closely when taking propranolol?

    <p>To assess for side effects</p> Signup and view all the answers

    What is a common adverse effect of amitriptyline used for migraine prevention?

    <p>Constipation</p> Signup and view all the answers

    Why is propranolol not recommended as the first-line drug in depressed patients?

    <p>It can worsen depression</p> Signup and view all the answers

    Which condition is a contraindication for using propranolol?

    <p>Chronic obstructive pulmonary disease</p> Signup and view all the answers

    What is the FDA indication for topiramate (Topamax) regarding migraine?

    <p>Has an indication for migraine prophylaxis</p> Signup and view all the answers

    Which tricyclic antidepressant (TCA) may be used for migraine prevention and causes less drowsiness than amitriptyline?

    <p>Nortriptyline (Pamelor)</p> Signup and view all the answers

    What is the recommended dosing strategy for NSAIDs in treating menstrual migraines?

    <p>Start daily dosing a week before menses and continue for a week after</p> Signup and view all the answers

    Which of the following is a potential concern with the use of NSAIDs in older patients?

    <p>Increased risk of nephrotoxicity or GI problems</p> Signup and view all the answers

    What is the level of evidence supporting the efficacy of calcium channel blockers for migraine prevention?

    <p>The data are weak and conflicting</p> Signup and view all the answers

    What is the proposed mechanism by which calcium channel blockers may prevent migraine?

    <p>Inhibiting vasospasm of the cerebral arteries and preventing cerebral hypoxia</p> Signup and view all the answers

    Which of the following is the most common calcium channel blocker used for migraine prevention?

    <p>Verapamil</p> Signup and view all the answers

    What is the level of recommendation from AAN and AHS for the use of ACE inhibitors and angiotensin receptor blockers (ARBs) for migraine prevention?

    <p>Level C recommendation</p> Signup and view all the answers

    Which of the following statements about botulinum toxin injection for migraine treatment is true?

    <p>It is effective for chronic migraine but not episodic migraine</p> Signup and view all the answers

    What is the recommended dosing strategy for onabotulinumtoxinA (Botox) in the treatment of chronic migraine?

    <p>An injection of 155 units in 31 sites divided across seven head and neck muscle areas, repeated every 12 weeks</p> Signup and view all the answers

    Which of the following is considered an important non-pharmacological management strategy for migraine?

    <p>Identifying and avoiding migraine triggers</p> Signup and view all the answers

    What percentage of patients who seek alternative therapy for migraine never discuss it with their health-care provider?

    <p>70%</p> Signup and view all the answers

    Which of the following is NOT recommended as a potential alternative therapy for migraine prevention?

    <p>Chemotherapy</p> Signup and view all the answers

    What is a potential mechanism by which biofeedback may help relieve migraine symptoms?

    <p>It modulates spontaneous discharge rates of cortical neurons</p> Signup and view all the answers

    Which of the following statements about transcranial direct current stimulation (tDCS) is TRUE according to the text?

    <p>It shifts neuronal resting membrane potential, thereby modulating spontaneous discharge rates</p> Signup and view all the answers

    Based on the information provided, what can be inferred about the recommendation for butterbur as a treatment for migraine?

    <p>It is no longer recommended due to safety and quality concerns</p> Signup and view all the answers

    What is the primary purpose of keeping a headache diary for migraine patients?

    <p>All of the above</p> Signup and view all the answers

    Which of the following statements about the PREMICE study is TRUE?

    <p>All of the above</p> Signup and view all the answers

    Based on the information provided, which of the following statements about acupuncture for migraine treatment is TRUE?

    <p>It is more effective than oral pharmacologic placebos</p> Signup and view all the answers

    Which of the following is a common food that can potentially trigger a migraine?

    <p>Chocolate</p> Signup and view all the answers

    Which of the following is NOT mentioned in the text as a potential lifestyle change that may help prevent migraines?

    <p>Regular exercise</p> Signup and view all the answers

    Which of the following alternative therapies has the strongest level of recommendation from the AAN and AHS?

    <p>Vitamins and minerals like riboflavin, magnesium, and feverfew</p> Signup and view all the answers

    Which medication has been shown in studies to be effective in the management of tension-type headache (TTH)?

    <p>All of the above</p> Signup and view all the answers

    What is the recommended daily dosage of gabapentin for the treatment of tension-type headache?

    <p>2,400 mg</p> Signup and view all the answers

    Which of the following nonpharmacological therapies is NOT mentioned in the text as helpful for the preventive treatment of tension-type headache?

    <p>Cognitive-behavioral therapy</p> Signup and view all the answers

    What is the primary purpose of keeping a headache diary for patients with tension-type headache?

    <p>All of the above</p> Signup and view all the answers

    Which of the following statements about new daily persistent headache (NDPH) is NOT true according to the text?

    <p>It is typically diagnosed in individuals with a prior history of migraine or tension-type headache</p> Signup and view all the answers

    What is the minimum duration of headache required for the diagnosis of new daily persistent headache (NDPH)?

    <p>3 months</p> Signup and view all the answers

    Which of the following therapies is NOT mentioned in the text as a potential treatment option for tension-type headache?

    <p>Transcranial magnetic stimulation</p> Signup and view all the answers

    What should be the frequency of monitoring for the effectiveness of acute or preventive medication prescribed for tension-type headache at the beginning of treatment?

    <p>Every 1 to 2 months</p> Signup and view all the answers

    Which of the following is NOT mentioned in the text as an important aspect of patient education for the treatment of tension-type headache?

    <p>Potential side effects of medications</p> Signup and view all the answers

    What is the primary reason for monitoring the use of combination drugs like butalbital and isometheptene compounds in the treatment of tension-type headache?

    <p>To safeguard against potential medication overuse headache developing from overuse</p> Signup and view all the answers

    What is the defining characteristic of New Daily Persistent Headache (NDPH)?

    <p>Sudden onset of daily headache</p> Signup and view all the answers

    What are the two subtypes of NDPH mentioned in the text?

    <p>Self-limiting and refractory</p> Signup and view all the answers

    Which of the following is true about the incidence and prevalence of NDPH?

    <p>The incidence and prevalence in the general population are unknown</p> Signup and view all the answers

    Which of the following viruses has been studied in relation to the potential etiology of NDPH?

    <p>Epstein-Barr virus</p> Signup and view all the answers

    What is the proposed pathogenesis of NDPH according to the text?

    <p>Persistent inflammation in the nervous system</p> Signup and view all the answers

    Which of the following statements about the treatment of NDPH is true according to the text?

    <p>The best approach is to manage symptoms based on chronicity and severity</p> Signup and view all the answers

    Which of the following medications has been recommended for the pharmacological treatment of NDPH?

    <p>Amitriptyline</p> Signup and view all the answers

    What is the recommended approach for monitoring patients with primary NDPH according to the text?

    <p>Monitor for efficacy of therapy, side effects, and refractory symptoms</p> Signup and view all the answers

    What should be done if a suspected primary NDPH fails to improve with treatment?

    <p>Consider the possibility of a secondary headache and refer for further evaluation</p> Signup and view all the answers

    What is recommended in the text regarding patient tracking of symptoms and treatment outcomes for NDPH?

    <p>Patients should track symptoms and treatment outcomes, as the therapeutic window might be narrow</p> Signup and view all the answers

    What is the primary focus of patient education for treating NDPH?

    <p>Emphasizing the biological origin of the disorder and the importance of avoiding medication overuse</p> Signup and view all the answers

    What is the key message regarding the use of nonpharmacological therapies in the treatment of NDPH?

    <p>Nonpharmacological therapies should be used to complement pharmacological treatments.</p> Signup and view all the answers

    What is the primary reason for closely monitoring patients with NDPH for mood alterations?

    <p>To determine if the patient is experiencing prolonged and refractory symptoms</p> Signup and view all the answers

    Which of the following is NOT a key aspect of patient education for NDPH?

    <p>Providing information about the general timeline for maintaining the dose of beta blockers</p> Signup and view all the answers

    What is the primary role of patient education in the treatment of NDPH?

    <p>To ensure the patient understands the overall treatment plan and adheres to the prescribed drug therapy</p> Signup and view all the answers

    Which of the following medications requires patients to have their liver function and complete blood count (CBC) tested every 2 weeks for a total of 6 weeks?

    <p>Divalproex</p> Signup and view all the answers

    What is the primary goal of migraine treatment according to the passage?

    <p>To minimize the impact of migraine headaches on patients' quality of life, social functioning, and ability to work</p> Signup and view all the answers

    How is the success of preventive therapy for frequent migraine sufferers evaluated?

    <p>Both b and c</p> Signup and view all the answers

    What is the recommended approach for patients who are unable to determine if a specific item is a migraine trigger?

    <p>Eliminate the item from their diet for 2 weeks and then reintroduce it</p> Signup and view all the answers

    What is the recommended treatment duration before changing the regimen for preventive therapy in frequent migraine sufferers?

    <p>2 to 3 months</p> Signup and view all the answers

    Which of the following is a characteristic of tension-type headaches (TTH) according to the passage?

    <p>Bilateral, persistent, and dull pain</p> Signup and view all the answers

    What is the recommended approach for patients to have a rescue strategy in place for acute migraines?

    <p>All of the above</p> Signup and view all the answers

    According to the passage, what is the lifetime prevalence range of tension-type headaches (TTH) in the general population?

    <p>30% to 78%</p> Signup and view all the answers

    What is a key difference between migraine and tension-type headaches (TTH) mentioned in the passage?

    <p>Migraine is worsened by physical activity, while TTH is not</p> Signup and view all the answers

    What is the recommended approach for patients who are unable to identify their migraine triggers?

    <p>Eliminate one item at a time from the common triggers list and monitor for improvements</p> Signup and view all the answers

    What is the primary goal of treatment for tension-type headaches?

    <p>Decrease headache frequency and severity</p> Signup and view all the answers

    Which neurotransmitters are modulated by TCAs to reduce the incidence of tension-type headaches?

    <p>Serotonin and norepinephrine</p> Signup and view all the answers

    Why should preventive therapy be considered for tension-type headache patients with increased frequency and disability?

    <p>To prevent medication overuse headaches (MOH)</p> Signup and view all the answers

    What role does nitric oxide (NO) play in the pathophysiology of tension-type headaches?

    <p>Key role</p> Signup and view all the answers

    Which medications have shown limited evidence for use in chronic tension-type headaches without any related harmful effects?

    <p>Topiramate and gabapentin</p> Signup and view all the answers

    What is the plausible reason behind the shift towards parenteral therapies like ketorolac in treating tension-type headaches?

    <p>Superiority over placebo shown in low-quality trials</p> Signup and view all the answers

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