Benzodiazepines and GABAA Receptor Quiz

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Questions and Answers

Which subunit of the GABAA receptor do barbiturates bind to?

  • α-subunit
  • γ-subunit
  • δ-subunit
  • β-subunit (correct)

What is the mechanism of action of Valium (Benzodiazepine) in terms of GABA receptors?

  • Inhibit GABA production
  • Potentiate GABA activity (correct)
  • Directly activate GABA receptors
  • Block GABA receptors

What are the potential consequences of an acute Benzodiazepine (Valium) overdose?

  • Hypertension, tachycardia, sweating
  • Hyperactivity, insomnia, anxiety
  • Respiratory depression, confusion, coma (correct)
  • Muscle twitching, seizures, euphoria

How does Naloxone act in reversing the toxic effects of certain drugs?

<p>Antagonizes opioid receptors (A)</p> Signup and view all the answers

What is the therapeutic dose range for Benzodiazepines like Valium for muscle-relaxing effects?

<p>Between 2.5 and 10 mg (C)</p> Signup and view all the answers

What is the therapeutic dose range for Dextromethorphan?

<p>15-30 mg (C)</p> Signup and view all the answers

What are the common symptoms of Dextromethorphan overdose?

<p>Respiratory depression and ataxia (A)</p> Signup and view all the answers

What is a characteristic effect of Fentanyl overdose?

<p>Hypoventilation and miosis (C)</p> Signup and view all the answers

How does Methadone differ from heroin in terms of addiction potential?

<p>Methadone is less addictive than heroin (A)</p> Signup and view all the answers

What is a major cause of drug-related death associated with Propoxyphene?

<p>Cardiac arrhythmias (A)</p> Signup and view all the answers

Which test is commonly used to differentiate Methadone from other opiates?

<p>Thin-layer chromatography (TLC) (A)</p> Signup and view all the answers

What is the mechanism of action by which barbiturates increase the duration of chloride ion channel opening?

<p>Direct gating of the chloride channel (C)</p> Signup and view all the answers

Which barbiturate is classified as ultra-short-acting?

<p>Thiopental (C)</p> Signup and view all the answers

What is the primary method for the treatment of barbiturate overdose?

<p>Activated charcoal (C)</p> Signup and view all the answers

How do barbiturates differ in their effect on the reticular activating system?

<p>Short-acting and ultra-short-acting barbiturates inhibit it selectively (A)</p> Signup and view all the answers

What is a common toxic manifestation associated with high doses of barbiturates?

<p>Areflexia (C)</p> Signup and view all the answers

Which enzyme system metabolizes almost all of the Methaqualone drug?

<p>Hepatic cytochrome P450 microsomal enzyme system (C)</p> Signup and view all the answers

Which process removes physical dependence on drugs?

<p>Supportive gradual diminution (D)</p> Signup and view all the answers

What is a distinct feature of barbiturates' binding site on the GABAA receptor?

<p>It is identical to benzodiazepine binding site (D)</p> Signup and view all the answers

How do barbiturates differ from benzodiazepines in terms of their interaction with GABA receptors?

<p>Barbiturates have a different binding site on the GABAA receptor compared to benzodiazepines (B)</p> Signup and view all the answers

What type of drugs are barbiturates and what makes them effective in reducing neuronal excitability?

<p>Anticonvulsants, due to their selective inhibition of rapidly firing neurons (A)</p> Signup and view all the answers

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