Benzodiazepines and GABAA Receptor Quiz

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Which subunit of the GABAA receptor do barbiturates bind to?

α-subunit

γ-subunit

δ-subunit

β-subunit (correct)

What is the mechanism of action of Valium (Benzodiazepine) in terms of GABA receptors?

Inhibit GABA production

Potentiate GABA activity (correct)

Directly activate GABA receptors

Block GABA receptors

What are the potential consequences of an acute Benzodiazepine (Valium) overdose?

Hypertension, tachycardia, sweating

Hyperactivity, insomnia, anxiety

Respiratory depression, confusion, coma (correct)

Muscle twitching, seizures, euphoria

How does Naloxone act in reversing the toxic effects of certain drugs?

Antagonizes opioid receptors Signup and view all the answers

What is the therapeutic dose range for Benzodiazepines like Valium for muscle-relaxing effects?

Between 2.5 and 10 mg Signup and view all the answers

What is the therapeutic dose range for Dextromethorphan?

15-30 mg Signup and view all the answers

What are the common symptoms of Dextromethorphan overdose?

Respiratory depression and ataxia Signup and view all the answers

What is a characteristic effect of Fentanyl overdose?

Hypoventilation and miosis Signup and view all the answers

How does Methadone differ from heroin in terms of addiction potential?

Methadone is less addictive than heroin Signup and view all the answers

What is a major cause of drug-related death associated with Propoxyphene?

Cardiac arrhythmias Signup and view all the answers

Which test is commonly used to differentiate Methadone from other opiates?

Thin-layer chromatography (TLC) Signup and view all the answers

What is the mechanism of action by which barbiturates increase the duration of chloride ion channel opening?

Direct gating of the chloride channel Signup and view all the answers

Which barbiturate is classified as ultra-short-acting?

Thiopental Signup and view all the answers

What is the primary method for the treatment of barbiturate overdose?

Activated charcoal Signup and view all the answers

How do barbiturates differ in their effect on the reticular activating system?

Short-acting and ultra-short-acting barbiturates inhibit it selectively Signup and view all the answers

What is a common toxic manifestation associated with high doses of barbiturates?

Areflexia Signup and view all the answers

Which enzyme system metabolizes almost all of the Methaqualone drug?

Hepatic cytochrome P450 microsomal enzyme system Signup and view all the answers

Which process removes physical dependence on drugs?

Supportive gradual diminution Signup and view all the answers

What is a distinct feature of barbiturates' binding site on the GABAA receptor?

It is identical to benzodiazepine binding site Signup and view all the answers

How do barbiturates differ from benzodiazepines in terms of their interaction with GABA receptors?

Barbiturates have a different binding site on the GABAA receptor compared to benzodiazepines Signup and view all the answers

What type of drugs are barbiturates and what makes them effective in reducing neuronal excitability?

Anticonvulsants, due to their selective inhibition of rapidly firing neurons Signup and view all the answers