21 Questions
Which subunit of the GABAA receptor do barbiturates bind to?
β-subunit
What is the mechanism of action of Valium (Benzodiazepine) in terms of GABA receptors?
Potentiate GABA activity
What are the potential consequences of an acute Benzodiazepine (Valium) overdose?
Respiratory depression, confusion, coma
How does Naloxone act in reversing the toxic effects of certain drugs?
Antagonizes opioid receptors
What is the therapeutic dose range for Benzodiazepines like Valium for muscle-relaxing effects?
Between 2.5 and 10 mg
What is the therapeutic dose range for Dextromethorphan?
15-30 mg
What are the common symptoms of Dextromethorphan overdose?
Respiratory depression and ataxia
What is a characteristic effect of Fentanyl overdose?
Hypoventilation and miosis
How does Methadone differ from heroin in terms of addiction potential?
Methadone is less addictive than heroin
What is a major cause of drug-related death associated with Propoxyphene?
Cardiac arrhythmias
Which test is commonly used to differentiate Methadone from other opiates?
Thin-layer chromatography (TLC)
What is the mechanism of action by which barbiturates increase the duration of chloride ion channel opening?
Direct gating of the chloride channel
Which barbiturate is classified as ultra-short-acting?
Thiopental
What is the primary method for the treatment of barbiturate overdose?
Activated charcoal
How do barbiturates differ in their effect on the reticular activating system?
Short-acting and ultra-short-acting barbiturates inhibit it selectively
What is a common toxic manifestation associated with high doses of barbiturates?
Areflexia
Which enzyme system metabolizes almost all of the Methaqualone drug?
Hepatic cytochrome P450 microsomal enzyme system
Which process removes physical dependence on drugs?
Supportive gradual diminution
What is a distinct feature of barbiturates' binding site on the GABAA receptor?
It is identical to benzodiazepine binding site
How do barbiturates differ from benzodiazepines in terms of their interaction with GABA receptors?
Barbiturates have a different binding site on the GABAA receptor compared to benzodiazepines
What type of drugs are barbiturates and what makes them effective in reducing neuronal excitability?
Anticonvulsants, due to their selective inhibition of rapidly firing neurons
Test your knowledge on the interaction between benzodiazepines and the GABAA receptor. Explore the mechanisms of action, binding sites, and effects of benzodiazepines on dopaminergic neurons.
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