Benzodiazepines and Their Mechanism of Action
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Questions and Answers

What is the mechanism of action of benzodiazepines on GABA receptors?

  • Activating serotonin receptors
  • Blocking chloride channels
  • Enhancing the effect of GABA (correct)
  • Increasing nerve impulses
  • Which of the following best describes the drug interactions of benzodiazepines?

  • Reduced sedative effects when taken with anticonvulsants
  • No interactions with any other medications
  • Enhanced effects when taken with CNS depressants (correct)
  • Most drugs interact with benzodiazepines except for alcohol
  • Which adverse reaction is NOT commonly associated with benzodiazepines?

  • Increased appetite (correct)
  • Fatigue
  • Dizziness
  • Amnesia
  • What could be the consequence of taking benzodiazepines with inhibitors of the CYP3A system?

    <p>Increased risk of toxicity</p> Signup and view all the answers

    What are some potential effects of benzodiazepines on sleep according to the text?

    <p>Reduced level of consciousness</p> Signup and view all the answers

    Which statement accurately describes the potential for dependence related to benzodiazepines?

    <p>Potential for abuse, tolerance, and physical dependence</p> Signup and view all the answers

    Which stage of sleep do benzodiazepines decrease the amount of time spent in?

    <p>Stage 3 and 4</p> Signup and view all the answers

    What is the advantage of benzodiazepines over barbiturates in terms of REM sleep?

    <p>Benzodiazepines do not affect REM sleep</p> Signup and view all the answers

    What neurotransmitter is involved in the mechanism of action of benzodiazepines?

    <p>GABA</p> Signup and view all the answers

    How do benzodiazepines affect the duration of rapid-eye-movement (REM) sleep?

    <p>Have no effect on REM sleep duration</p> Signup and view all the answers

    What is the primary clinical indication for benzodiazepines?

    <p>Relaxing the patient during surgery</p> Signup and view all the answers

    Which stage of sleep resembles brain activity when awake and is characterized by relaxed muscles and rapid eye movements?

    <p>REM sleep</p> Signup and view all the answers

    Which of the following is a key consideration when prescribing benzodiazepines to elderly patients?

    <p>Using those with long half-life or active metabolites</p> Signup and view all the answers

    What is the major pharmacologic action of barbiturates?

    <p>Reduce CNS alertness</p> Signup and view all the answers

    Which part of the brain is particularly sensitive to the effects of barbiturates?

    <p>Reticular activating system (RAS)</p> Signup and view all the answers

    What is the primary route of excretion for barbiturates?

    <p>Kidneys</p> Signup and view all the answers

    Which CNS function is altered by barbiturates to induce drowsiness?

    <p>Cerebral function</p> Signup and view all the answers

    What is a potential adverse effect of high doses of barbiturates?

    <p>Respiratory depression</p> Signup and view all the answers

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