Benzodiazepines and Their Mechanism of Action
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Questions and Answers

What is the mechanism of action of benzodiazepines on GABA receptors?

  • Activating serotonin receptors
  • Blocking chloride channels
  • Enhancing the effect of GABA (correct)
  • Increasing nerve impulses

Which of the following best describes the drug interactions of benzodiazepines?

  • Reduced sedative effects when taken with anticonvulsants
  • No interactions with any other medications
  • Enhanced effects when taken with CNS depressants (correct)
  • Most drugs interact with benzodiazepines except for alcohol

Which adverse reaction is NOT commonly associated with benzodiazepines?

  • Increased appetite (correct)
  • Fatigue
  • Dizziness
  • Amnesia

What could be the consequence of taking benzodiazepines with inhibitors of the CYP3A system?

<p>Increased risk of toxicity (B)</p> Signup and view all the answers

What are some potential effects of benzodiazepines on sleep according to the text?

<p>Reduced level of consciousness (A)</p> Signup and view all the answers

Which statement accurately describes the potential for dependence related to benzodiazepines?

<p>Potential for abuse, tolerance, and physical dependence (C)</p> Signup and view all the answers

Which stage of sleep do benzodiazepines decrease the amount of time spent in?

<p>Stage 3 and 4 (C)</p> Signup and view all the answers

What is the advantage of benzodiazepines over barbiturates in terms of REM sleep?

<p>Benzodiazepines do not affect REM sleep (C)</p> Signup and view all the answers

What neurotransmitter is involved in the mechanism of action of benzodiazepines?

<p>GABA (C)</p> Signup and view all the answers

How do benzodiazepines affect the duration of rapid-eye-movement (REM) sleep?

<p>Have no effect on REM sleep duration (A)</p> Signup and view all the answers

What is the primary clinical indication for benzodiazepines?

<p>Relaxing the patient during surgery (A)</p> Signup and view all the answers

Which stage of sleep resembles brain activity when awake and is characterized by relaxed muscles and rapid eye movements?

<p>REM sleep (C)</p> Signup and view all the answers

Which of the following is a key consideration when prescribing benzodiazepines to elderly patients?

<p>Using those with long half-life or active metabolites (C)</p> Signup and view all the answers

What is the major pharmacologic action of barbiturates?

<p>Reduce CNS alertness (D)</p> Signup and view all the answers

Which part of the brain is particularly sensitive to the effects of barbiturates?

<p>Reticular activating system (RAS) (A)</p> Signup and view all the answers

What is the primary route of excretion for barbiturates?

<p>Kidneys (D)</p> Signup and view all the answers

Which CNS function is altered by barbiturates to induce drowsiness?

<p>Cerebral function (A)</p> Signup and view all the answers

What is a potential adverse effect of high doses of barbiturates?

<p>Respiratory depression (C)</p> Signup and view all the answers

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