Benzodiazepines and GABA Receptors

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5 Questions

Which tissue acts as a reservoir for lipophilic benzodiazepines?

Adipose tissue

What effect do benzodiazepines have on GABA receptor-mediated neurotransmission?

They potentiate the inhibition of neurotransmission

Which route of administration results in erratic and slow absorption of benzodiazepines?

IV (Intravenous)

Which benzodiazepine is classified as having a long duration of action?

Flurazepam

In what way do benzodiazepines affect the GABA receptor channel?

They open the chloride channel when GABA is bound, leading to neuron hyperpolarization

This quiz covers the pharmacodynamics of benzodiazepines, which are moderate CNS depressants acting as anxiolytics and hypnotics. It also explores their mechanism of action on the GABA receptor, potentiating the inhibition of GABA-mediated neurotransmission.

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