5 Questions
What is the only solid criterion of malignancy?
Metastasis
What do well-differentiated tumors, whether benign or malignant, retain?
Morphologic and functional characteristics of their normal counterparts
What term refers to the lack of differentiation in tumors?
Anaplasia
Which type of tumor is characterized by marked variation in cell and nuclear sizes, hyperchromatic nuclei, and tumor giant cells?
Anaplastic tumor
What is the term used for the ability of malignant cells to revert to embryologic phenotypes or express proteins not elaborated by the original cell of origin?
Anaplastic transformation
Study Notes
Criteria of Malignancy
- The only solid criterion of malignancy is the presence of metastasis.
Tumor Differentiation
- Well-differentiated tumors, whether benign or malignant, retain their normal tissue structure and function.
Lack of Differentiation
- The term used to describe the lack of differentiation in tumors is anaplasia.
Characteristics of Anaplastic Tumors
- Anaplastic tumors are characterized by marked variation in cell and nuclear sizes, hyperchromatic nuclei, and tumor giant cells.
Embryologic Phenotypes
- The ability of malignant cells to revert to embryologic phenotypes or express proteins not elaborated by the original cell of origin is known as dedifferentiation.
Learn about the characteristics of benign and malignant tumors, including their classification based on clinical behavior, differentiation, anaplasia, local invasion, and metastasis. Explore the differences between neoplasm types, such as epithelial and connective tissue tumors.
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