Benign Tumors: Fibrocystic Changes and More
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Questions and Answers

Which of the following changes in fibrocystic change has the highest associated risk for invasive carcinoma?

  • Ductal hyperplasia
  • Atypical hyperplasia (correct)
  • Sclerosing adenosis
  • Fibrosis
  • What characterizes the appearance of cysts found in fibrocystic changes of the breast?

  • Irregular calcifications
  • Greenish thick discharge
  • Blue-dome appearance (correct)
  • Solid white masses on imaging
  • In which population is the fibroadenoma most commonly observed?

  • Women undergoing hormone therapy
  • Postmenopausal women
  • Adolescents
  • Premenopausal women (correct)
  • What distinguishes an intraductal papilloma from papillary carcinoma?

    <p>Underlying myoepithelial cells</p> Signup and view all the answers

    Which of the following characteristics applies to phyllodes tumors?

    <p>They can be malignant</p> Signup and view all the answers

    Study Notes

    Benign Tumors and Fibrocystic Changes

    • Fibrocystic Change:
      • Development of fibrosis and cysts in the breast
      • Most common in premenopausal women
      • Presents as breast tissue irregularity ("lumpy breast"), typically in the upper outer quadrant
      • Cysts appear as blue-domed masses on examination
      • Some related changes increase risk of invasive carcinoma
        • Fibrosis, cysts, and apocrine metaplasia: no increased risk
        • Ductal hyperplasia and sclerosing adenosis: 2x increased risk
        • Atypical hyperplasia: 5x increased risk

    Intraductal Papilloma

    • Characteristics:
      • Papillary growth within a large milk duct
      • Composed of fibrovascular projections lined by epithelial and myoepithelial cells
      • Often presents with bloody nipple discharge, especially in premenopausal women
      • Important to differentiate from papillary carcinoma, which also presents with bloody nipple discharge

    Fibroadenoma

    • Characteristics:
      • A benign tumor composed of fibrous tissue and glands
      • The most common benign breast neoplasm; typically seen in premenopausal women
      • Presents as a well-circumscribed, mobile, and marble-like mass
      • Estrogen-sensitive; may grow during pregnancy and be painful during menstruation
      • Shrinks in size after menopause
      • No increased risk of carcinoma

    Phyllodes Tumor

    • Characteristics:
      • Fibroadenoma-like tumor with overgrowth of fibrous component; characteristic "leaf-like" projections on biopsy
      • Most commonly found in postmenopausal women
      • Can be malignant in some cases

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    Description

    This quiz covers benign tumors such as fibrocystic changes, intraductal papillomas, and fibroadenomas. It focuses on their characteristics, presentation, and implications for breast health. Test your knowledge on the important distinctions and risks associated with these conditions.

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