Basic Concepts in Human Virology Quiz
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Questions and Answers

What is the tiniest simplest form of life on earth according to the text?

  • Bacteria
  • Protozoa
  • Fungi
  • Virus (correct)

Why did 15th century Italians call the disease Influenza?

  • Because they believed it was caused by the influence of stars and plants (correct)
  • Because it was caused by bacteria
  • Because it originated from Asia
  • Because it affected the lungs

What is the term for an organism that must have a cell to replicate?

  • Archaea
  • Eukaryote
  • Virus (correct)
  • Prokaryote

Where does a virus become a 'virus particle' with no activity or metabolism?

<p>Outside of the host cell (C)</p> Signup and view all the answers

What process allows a virus to replicate inside an infected cell?

<p>Protein synthesis (A)</p> Signup and view all the answers

Why are viruses considered not cellular organisms?

<p>Because they cannot perform metabolism on their own outside of a cell (D)</p> Signup and view all the answers

What is the key factor that determines the survival of viruses according to the text?

<p>Spreading capacity (D)</p> Signup and view all the answers

'Virus-Host Equilibrium' refers to what concept?

<p>'Virus-Host' relationship maintaining survival balance (D)</p> Signup and view all the answers

What is one of the major reasons why Ebola virus outbreaks are limited to Africa?

<p>Africa has a specific ecological environment that favors the virus. (D)</p> Signup and view all the answers

In what year did Influenza virus of 1919 demonstrate better equilibrium?

<p>1976 (C)</p> Signup and view all the answers

Why is Ramesses V's preserved mummy mentioned in the text?

<p>As an illustration of an ancient smallpox infection. (A)</p> Signup and view all the answers

Which characteristic is shared by all cellular life forms according to the text?

<p>Ability to reproduce by division. (C)</p> Signup and view all the answers

Why did Dmitri Iwanowski's work in 1892 open the field called VIROLOGY?

<p>He demonstrated that a small infectious agent smaller than bacteria can transmit disease. (B)</p> Signup and view all the answers

Why are viruses unable to survive on their own in most cases?

<p>Viruses require a host cell for replication and survival. (C)</p> Signup and view all the answers

What major characteristic distinguishes virus particles from cellular organisms?

<p>'DNA must be expressed all the time.' (C)</p> Signup and view all the answers

How did seasonal flu outbreaks differ between 1918 and 1957 according to the text?

<p>'1918 had a higher death rate.' (B)</p> Signup and view all the answers

What is a characteristic of lysogenic viral replication?

<p>Viral genome is incorporated into the host's chromosomes (D)</p> Signup and view all the answers

Which type of RNA viruses have complementary base sequences in their genome compared to viral mRNAs?

<p>Negative-sense RNA viruses (D)</p> Signup and view all the answers

What is the main difference between segmented and non-segmented viruses?

<p>Segmented viruses have their genome divided into many chromosomes (C)</p> Signup and view all the answers

Which phase of viral replication involves the production of viral proteins?

<p>The assembly of new virus particles (B)</p> Signup and view all the answers

What enzyme is required to separate enzymes in a viral infection?

<p>Protease (D)</p> Signup and view all the answers

In which type of RNA virus does the genome contain sequences similar to mRNA?

<p>+ssRNA (B)</p> Signup and view all the answers

What is the initial step in the translation of -ssRNA viruses?

<p>+ssRNA copying (D)</p> Signup and view all the answers

Which cells house viral memory cells that sustain lifelong infections?

<p>White blood cells (B)</p> Signup and view all the answers

'Lytic' and 'Lysogenic' are terms related to which aspect of viral life cycles?

<p>'Lytic' refers to a viral replication cycle, while 'Lysogenic' refers to a dormant state within the host. (A)</p> Signup and view all the answers

'Lyso' in lysogenic is derived from which word, hinting at its nature?

<p>'Lysis' (D)</p> Signup and view all the answers

What did a virologist in the 20th century famously describe a virus as?

<p>A piece of bad news wrapped in a protein (D)</p> Signup and view all the answers

When viruses can sense the presence of the immune system, what action do they typically take?

<p>Reduce replication to avoid immune system detection (C)</p> Signup and view all the answers

In what year did the transfer of smallpox from Europe to the Americas occur?

<p>1519 A.D (D)</p> Signup and view all the answers

Which virus infected about 350 million people worldwide in a chronic way?

<p>Hepatitis B virus (A)</p> Signup and view all the answers

Which virus caused 50-100 million deaths worldwide during the 1918 pandemic?

<p>Spanish Flu virus (B)</p> Signup and view all the answers

Which of the following are common causes of acute infections in humans according to the text?

<p>Viruses (A)</p> Signup and view all the answers

What is a key characteristic of viruses in terms of their presence in the human genome?

<p>Viruses account for the first 8% of our genome (D)</p> Signup and view all the answers

What is a characteristic shared by rabies, Ebola, and smallpox viruses according to the text?

<p>High mortality rates (A)</p> Signup and view all the answers

What is a significant role that viruses like varicella zoster play in human infections according to the text?

<p>Triggering early infections for immunity development (A)</p> Signup and view all the answers

What is the impact of the varicella zoster virus on human infections according to the text?

<p>We need them to infect us early as possible</p> Signup and view all the answers

What significant event occurred in 1519 A.D regarding smallpox?

<p>Transferred from Europe to the Americas</p> Signup and view all the answers

How did Hernando Cortes contribute to the spread of smallpox?

<p>Invaded Mexico and conquered millions of Aztecs</p> Signup and view all the answers

What factors contributed to the defenselessness of the Aztecs in the face of smallpox?

<p>Less than 600 men helped, horses, weapons</p> Signup and view all the answers

What were the major factors that caused significant mortality in the U.S according to the text?

<p>Obesity, tobacco, and alcohol</p> Signup and view all the answers

What is the most common cause of acute infections in humans according to the text?

<p>Viruses</p> Signup and view all the answers

How many total virus infections in the world exceed several billion cases each year in adults?

<p>Several billions</p> Signup and view all the answers

What viruses have high mortality rates according to the text?

<p>Rabies, Ebola, smallpox</p> Signup and view all the answers

Which viruses can lead to long-term disability?

<p>Polio, rubella</p> Signup and view all the answers

What is the key characteristic that distinguishes virus particles from cellular organisms according to the text?

<p>They cannot survive on their own</p> Signup and view all the answers

Explain the historical impact of viruses on human history.

<p>Viruses have caused devastating diseases throughout history, impacting populations like war and natural disasters.</p> Signup and view all the answers

What is the significance of the term 'Influenza' and why did 15th century Italians use it?

<p>The term 'Influenza' was coined by 15th century Italians, who believed it was caused by the influence of stars and planets.</p> Signup and view all the answers

Describe the concept of obligate intracellular parasites in relation to viruses.

<p>Obligate intracellular parasites are viruses that require a host cell to replicate, as they cannot perform metabolism on their own.</p> Signup and view all the answers

Explain the importance of virus-host equilibrium in the survival of viruses.

<p>Virus-host equilibrium is crucial for the survival of viruses, as their natural evolution operates on spreading capacity rather than disease-causing ability.</p> Signup and view all the answers

What is the role of mutants in the survival of viruses?

<p>Viruses produce a large number of mutants to survive, with selection removing non-fittest strains.</p> Signup and view all the answers

Discuss the impact of the death of an infected host on the survival of the infecting virus.

<p>The death of an infected host compromises the survival of the infecting virus, as viruses cannot replicate without a host.</p> Signup and view all the answers

Explain the process of viral replication inside an infected cell.

<p>Inside an infected cell, a virus can replicate to make proteins, enter the nucleus, and produce genome proteins before leaving the cell.</p> Signup and view all the answers

What is the main reason why viruses are considered not cellular organisms?

<p>Viruses are not considered cellular organisms because they lack the ability to perform metabolism on their own outside of a host cell.</p> Signup and view all the answers

Describe the natural evolution process of viruses in terms of spreading capacity.

<p>The natural evolution of viruses operates on their spreading capacity rather than their ability to cause disease.</p> Signup and view all the answers

How do viruses like varicella zoster impact human infections according to the text?

<p>Viruses like varicella zoster play a significant role in causing acute infections in humans.</p> Signup and view all the answers

What is the significance of the hieroglyph from Memphis in 3700BC?

<p>First written record of a virus infection</p> Signup and view all the answers

How did the Influenza virus of 1919 demonstrate better equilibrium?

<p>Killing people but not at the same level as 1918</p> Signup and view all the answers

What disease did Ramesses V die from in 1143 B.C.?

<p>Smallpox</p> Signup and view all the answers

What did Dmitri Iwanowski's work in 1892 lead to in the field of virology?

<p>Birth of the field called VIROLOGY</p> Signup and view all the answers

What is the impact of Ebola virus outbreaks on infected people?

<p>Death up to 90% of infected people shortly after infection</p> Signup and view all the answers

What is the impact of polio infection on most people?

<p>Totally asymptomatic, can spread the virus</p> Signup and view all the answers

How did seasonal flu outbreaks differ between 1918 and 1957?

<p>1918 had a higher death toll</p> Signup and view all the answers

What is the main characteristic of virus particles that distinguishes them from cellular organisms?

<p>Not cellular organism</p> Signup and view all the answers

What is the purpose of a virus solely replicating and infecting other host cells?

<p>To make many copies and infect other host cells</p> Signup and view all the answers

What did Dmitri Iwanowski's discovery reveal about infectious agents in 1892?

<p>Smaller than a bacteria</p> Signup and view all the answers

What is the major distinguishing factor between lytic and lysogenic viral replication cycles?

<p>In lysogenic cycle, viruses are incorporated into the host's chromosome, while in lytic cycle, viruses are released from the host cell after replication.</p> Signup and view all the answers

Explain the impact of HIV infection being lysogenic on human health.

<p>HIV can stay in memory cells for life, leading to lifelong infection and continuous production of new virus particles.</p> Signup and view all the answers

What is the main reason behind viruses like HIV infecting humans for life?

<p>The infection of memory cells by HIV allows the virus to persist in the body indefinitely.</p> Signup and view all the answers

How do segmented viruses, like rotavirus, differ from non-segmented viruses in terms of genome structure?

<p>Segmented viruses have their genome made of many chromosomes, while non-segmented viruses have a single chromosome.</p> Signup and view all the answers

Explain the significance of RNA-dependent RNA polymerase in viral replication.

<p>RNA-dependent RNA polymerase is crucial for copying the viral RNA genome into a form that can be translated and used to produce viral proteins.</p> Signup and view all the answers

What is the primary function of RNA-dependent RNA polymerase in a newly infected cell?

<p>It helps in copying the viral RNA genome into a form suitable for translation into viral proteins.</p> Signup and view all the answers

Describe the role of memory cells in sustaining lifelong infections by viruses like HIV.

<p>Memory cells provide a reservoir for viruses to persist in the body, leading to lifelong infections.</p> Signup and view all the answers

How does the presence of memory cells contribute to the chronicity of certain viral infections?

<p>Memory cells act as a long-term reservoir for viruses, allowing them to continuously produce new virus particles.</p> Signup and view all the answers

What is the significance of viral memory cells in the context of lifelong infections?

<p>Viral memory cells provide a long-term source for continuous production of new virus particles, leading to lifelong infections.</p> Signup and view all the answers

Explain the importance of separating viral enzymes in the infected cell during viral replication.

<p>Separating viral enzymes allows for the activation of specific functions, such as producing structural or processed proteins.</p> Signup and view all the answers

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