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Questions and Answers
What does base excision repair (BER) replace in DNA?
What does base excision repair (BER) replace in DNA?
- Proteins
- Entire DNA strands
- Damaged bases (correct)
- RNA sequences
Which enzyme is involved in recognizing and removing uracil in BER?
Which enzyme is involved in recognizing and removing uracil in BER?
- DNA glycosylase (correct)
- Ligase
- OGG1
- DNA polymerase
What is created in DNA after a uracil base is removed by DNA glycosylase in BER?
What is created in DNA after a uracil base is removed by DNA glycosylase in BER?
- Double-strand break
- Protein complex
- AP site (correct)
- RNA strand
Which enzyme cleaves the gap created after the removal of uracil in BER?
Which enzyme cleaves the gap created after the removal of uracil in BER?
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Which of the following is NOT involved in the BER process?
Which of the following is NOT involved in the BER process?
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Study Notes
Base Excision Repair (BER)
- Damaged bases are replaced by new ones through the DNA repair process called Base Excision Repair (BER)
- Numerous DNA glycosylases, including 8-oxoguanine DNA glycosylase (OGG1), are involved in identifying and eliminating damaged bases
- BER includes two sub-pathways: short patch repair and long patch repair
- Short patch repair involves breaking down and filling an abasic site by certain enzymes
- Long patch repair involves targeting gaps, performing DNA synthesis, and then ligation
- BER is responsible for repairing uracil-containing DNA
- The repair of uracil-containing DNA involves the following steps:
- A DNA glycosylase recognizes and removes the uracil base, creating a gap in the DNA called an AP site
- The AP site is then cleaved by an enzyme called AP endonuclease
- The remaining sugar is removed
- The gap is filled using DNA polymerase
- The gap is sealed with ligase
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Description
Learn about the DNA repair process called Base Excision Repair (BER), involving DNA glycosylases and two sub-pathways: short patch repair and long patch repair. Understand how damaged bases are replaced with new ones.
