Bailey & Love Chapter 1: Metabolic Response to Injury

Metabolic Response to Injury

• The physiological and biochemical changes that occur during injury and recovery are described as the metabolic response to injury.

Mediators of Metabolic Response

• The mediators involved in the metabolic response to injury do not include bradykinin.

Consequences of Metabolic Response

• The abnormal processes resulting from the metabolic response to injury can lead to potential consequences such as sepsis, MODS, and multiple organ dysfunction syndrome.

Surgical Stress Response

• The surgical stress response affects glucose metabolism, proteolysis, and lipolysis.

Alterations in Body Metabolism

• The metabolic response to injury leads to alterations in body metabolism, wound healing, and immunity.

Complications of Metabolic Response

• The main cause of complications such as sepsis in the context of tissue injury is the metabolic response to injury.

Catabolic Phase

• The main physiological role of the catabolic phase in the metabolic response to injury is to mobilize energy stores and support the body's response to injury.
• The catabolic phase is characterized by increased glucose production, proteolysis, and lipolysis.

Importance of Homeostasis

• The concept of maintaining a constant internal environment for optimal cellular function is known as homeostasis.

Role of Surgical Critical Care

• The role of surgical critical care during the metabolic effects of injury is to support the body's response to injury and manage complications.

Systemic Effects of Metabolic Response

• The condition that involves loss of muscle mass, sepsis, and MODS as systemic effects is known as cachexia.

Anabolic Phase

• The anabolic (rebuilding) phase develops after serious injury during the recovery phase.

Avoidable Factors

• The avoidable factors that compound the metabolic response to injury are known as iatrogenic factors.

Basis of Modern Perioperative Care

• The basis of modern perioperative care is that successful management of the metabolic response improves outcomes.

Primary Purpose of Resuscitation and Organ Support

• The primary purpose of resuscitation and/or organ support in surgical critical care is to restore tissue perfusion and prevent organ dysfunction.

Test your knowledge on the metabolic response to injury and surgery with this quiz based on Bailey & Love's principles. Learn about the physiological and biochemical changes that occur during injury and recovery, as well as the mediators and pathways of the metabolic response to injury.