unit 4 , chapter 6
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Questions and Answers

Which of the following best describes a virus?

  • A living organism composed of nucleic acid and protein
  • A small organism that can multiply outside of host cells
  • A type of bacteria that infects humans
  • A non-living parasite that infects host cells (correct)

What is the main reason why viruses are not included in the tree of life?

  • They do not have a cellular structure (correct)
  • They are too small to be classified
  • They are not composed of DNA or RNA
  • They cannot multiply outside of host cells

What is the role of the host cell in viral replication?

  • The host cell releases the virus particles
  • The host cell protects the virus from the immune system
  • The host cell assembles the virus particles (correct)
  • The host cell provides energy for the virus to replicate

What is meant by the term 'host range' in relation to viruses?

<p>The range of hosts that a virus can infect (A)</p> Signup and view all the answers

How can viruses be transmitted from one host to another?

<p>Through physical contact with arthropods (B)</p> Signup and view all the answers

Which step in the life cycle of animal viruses involves the attachment of the virus to the plasma membrane of the host cell?

<p>Penetration (A)</p> Signup and view all the answers

Which type of animal virus enters the host cell by fusing its envelope with the plasma membrane?

<p>Enveloped virus (C)</p> Signup and view all the answers

Which type of animal virus is taken into the host cell by endocytosis?

<p>Non-enveloped virus (C)</p> Signup and view all the answers

Which type of animal virus requires reverse transcriptase to generate a provirus?

<p>RNA virus (C)</p> Signup and view all the answers

Which step in the viral growth curve is characterized by the release of many viral particles into the medium?

<p>Burst (B)</p> Signup and view all the answers

Which step of the one-step multiplication curve for a bacteriophage population involves the entry of the viral genome into the host cell?

<p>Eclipse (D)</p> Signup and view all the answers

What is the burst size in the context of a bacteriophage population?

<p>The maximum number of virions produced per bacterium (C)</p> Signup and view all the answers

How can virions in a liquid medium be separated from host cells?

<p>By both centrifugation and filtration (C)</p> Signup and view all the answers

In the context of virus cultivation, what is a bacterial lawn?

<p>A layer of bacteria grown in a Petri dish (D)</p> Signup and view all the answers

What is the primary cell culture?

<p>Cells isolated from animal organs or tissues and suspended in a solution of nutrients (D)</p> Signup and view all the answers

Which category of viruses has an envelope in addition to capsid?

<p>Enveloped viruses (C)</p> Signup and view all the answers

What are the two types of spikes found in the Influenza virus?

<p>Hemagglutin and Neuraminidase (B)</p> Signup and view all the answers

What is the function of Neuraminidase spike in the Influenza virus?

<p>Helps release virions from the host cell after replication and assembly (D)</p> Signup and view all the answers

How are viruses classified into families and genera?

<p>Based on viral genetics, chemistry, morphology, and mechanism of multiplication (A)</p> Signup and view all the answers

What happens in the lytic cycle of a bacteriophage?

<p>The phage infects and replicates within a bacterial cell (A)</p> Signup and view all the answers

Which type of agents can inactivate viruses?

<p>Physical agents (C)</p> Signup and view all the answers

Which of the following is true about antiviral drugs?

<p>They inhibit virus replication (D)</p> Signup and view all the answers

Which enzyme do neuraminidase inhibitors target?

<p>Neuraminidase (C)</p> Signup and view all the answers

Which antiviral drug is used to treat respiratory syncytial virus (RSV)?

<p>Ribavirin (D)</p> Signup and view all the answers

Which type of drugs react with HIV protease to reduce protein size and make capsid?

<p>Protease inhibitors (A)</p> Signup and view all the answers

Which type of cell culture is affected by contact inhibition?

<p>Primary cell cultures (D)</p> Signup and view all the answers

What is the main difference between viroids and virusoids?

<p>Viroids are self-replicating, while virusoids are not (C)</p> Signup and view all the answers

What is the cause of transmissible spongiform encephalopathies (TSEs)?

<p>Prions (A)</p> Signup and view all the answers

What is the role of normal prion protein (PrPc) in prion diseases?

<p>It gets converted into the disease-causing form (PrPsc) (D)</p> Signup and view all the answers

Which of the following is NOT a prion disease in humans?

<p>Chronic wasting disease (B)</p> Signup and view all the answers

Which enzyme do neuraminidase inhibitors target?

<p>Neuraminidase (B)</p> Signup and view all the answers

Which type of drugs react with HIV protease to reduce protein size and make capsid?

<p>Protease inhibitors (C)</p> Signup and view all the answers

Which type of agents can inactivate viruses?

<p>Chemical agents (D)</p> Signup and view all the answers

Which step in the life cycle of animal viruses involves the attachment of the virus to the plasma membrane of the host cell?

<p>Attachment (C)</p> Signup and view all the answers

What is the main reason why viruses are not included in the tree of life?

<p>They lack metabolic machinery (C)</p> Signup and view all the answers

Which step in the life cycle of animal viruses involves the attachment of the virus to the plasma membrane of the host cell?

<p>Attachment-Binding facilitated by spikes distributed over the surface of the capsid (C)</p> Signup and view all the answers

Which type of animal virus requires reverse transcriptase to generate a provirus?

<p>RNA virus (C)</p> Signup and view all the answers

What is the role of reverse transcriptase in the replication of RNA viruses?

<p>Synthesis of +ssRNA from -ssRNA (C)</p> Signup and view all the answers

Which step of the viral growth curve is characterized by the release of many viral particles into the medium?

<p>Burst (C)</p> Signup and view all the answers

What is the primary site of integration for the varicella-zoster virus during a latent infection?

<p>Host cell nucleus (A)</p> Signup and view all the answers

Which of the following best describes a virus?

<p>A submicroscopic, infectious, parasitic, non-living agent composed of nucleic acid surrounded by a protein coat (A)</p> Signup and view all the answers

What is the primary function of a virus' capsid structure?

<p>To help the virus attach to host cells (D)</p> Signup and view all the answers

What is the host range of a virus?

<p>The range of organisms that a virus can infect (A)</p> Signup and view all the answers

How can viruses be transmitted from one host to another?

<p>All of the above (D)</p> Signup and view all the answers

What is the role of the host cell in viral replication?

<p>To serve as a site for viral replication (C)</p> Signup and view all the answers

Which type of cell culture is not affected by contact inhibition?

<p>Continuous cell culture (D)</p> Signup and view all the answers

Which of the following is a characteristic of viroids?

<p>Require a helper virus for replication (A)</p> Signup and view all the answers

Which of the following is NOT a virus-like agent?

<p>Bacteriophages (D)</p> Signup and view all the answers

Which of the following is a characteristic of prions?

<p>Can be infectious (B)</p> Signup and view all the answers

Which of the following is a transmissible spongiform encephalopathy caused by prions?

<p>Mad cow disease (C)</p> Signup and view all the answers

What is the burst size in the context of a bacteriophage population?

<p>The maximum number of virions produced per bacterium (C)</p> Signup and view all the answers

What is the main difference between in vivo and in vitro cultivation of viruses?

<p>In vivo cultivation requires a living host organism, while in vitro cultivation is done outside a living organism (A)</p> Signup and view all the answers

Which of the following is NOT a source for in vivo cultivation of animal viruses?

<p>Yolk sac (C)</p> Signup and view all the answers

What is the main advantage of using continuous cell lines for virus culture?

<p>They can be grown indefinitely without contact inhibition (B)</p> Signup and view all the answers

How can virions be separated from host cells in virus cultivation?

<p>By both centrifugation and filtration (B)</p> Signup and view all the answers

Which of the following is NOT a category of viruses based on general composition?

<p>Spiked viruses (C)</p> Signup and view all the answers

What is the function of Hemagglutin (H) spike in the Influenza virus?

<p>Helps the virion attach and penetrate host cells (A)</p> Signup and view all the answers

Which of the following is true about temperate phages?

<p>They can become part of a host chromosome and are replicated with the cell genome (D)</p> Signup and view all the answers

Which step in the life cycle of T-even bacteriophage involves the degradation of the bacterial chromosome and synthesis of multiple copies of viral DNA?

<p>Biosynthesis (B)</p> Signup and view all the answers

What happens in the lytic cycle of a virulent bacteriophage?

<p>The phage replicates and lyses the host cell (A)</p> Signup and view all the answers

Which step in the one-step multiplication curve of a bacteriophage population involves the entry of the viral genome into the host cell?

<p>Eclipse (B)</p> Signup and view all the answers

What is the maximum number of virions produced per bacterium known as?

<p>Burst (C)</p> Signup and view all the answers

How can virions in a liquid medium be separated from host cells?

<p>Both centrifugation and filtration (C)</p> Signup and view all the answers

Which type of cell culture has a limited life span and is prone to contact inhibition?

<p>Primary cell culture (A)</p> Signup and view all the answers

What is the main reason why viruses require a living host cell for replication?

<p>To ensure efficient replication of their genetic material (D)</p> Signup and view all the answers

Which of the following is NOT a viral structure?

<p>Cytosol (B)</p> Signup and view all the answers

Which type of viruses have an envelope in addition to a capsid?

<p>Complex viruses (A)</p> Signup and view all the answers

What is the role of the Hemagglutin (H) spike in the Influenza virus?

<p>Helps the virion attach and penetrate host cells (A)</p> Signup and view all the answers

What is the main advantage of using continuous cell lines for virus culture?

<p>They can be maintained and propagated indefinitely (D)</p> Signup and view all the answers

What happens in the lysogenic cycle of a temperate bacteriophage?

<p>The phage DNA is incorporated into the host genome (C)</p> Signup and view all the answers

Which step in the life cycle of animal viruses involves the integration of the viral genome into the host cell genome?

<p>Replication (A)</p> Signup and view all the answers

Which type of animal virus enters the host cell by fusing its envelope with the plasma membrane?

<p>Enveloped viruses (A)</p> Signup and view all the answers

Which type of animal virus is taken into the cell by endocytosis?

<p>Non-enveloped viruses (A)</p> Signup and view all the answers

Which type of animal virus requires reverse transcriptase to generate a provirus?

<p>RNA viruses (B)</p> Signup and view all the answers

Which step in the life cycle of animal viruses involves the release of new virions from the host cell?

<p>Release (B)</p> Signup and view all the answers

Which type of agents can inactivate viruses?

<p>Physical agents (C)</p> Signup and view all the answers

Which of the following is true about antiviral drugs?

<p>They inhibit virus replication (C)</p> Signup and view all the answers

What is the mode of action of neuraminidase inhibitors?

<p>They prevent release of new virions (A)</p> Signup and view all the answers

Which of the following is an example of a reverse transcriptase inhibitor?

<p>Azidothymidine (AZT) (D)</p> Signup and view all the answers

What is the mode of action of protease inhibitors?

<p>They inhibit viral maturation/release (C)</p> Signup and view all the answers

Which of the following best describes a virus?

<p>A submicroscopic, infectious, parasitic, non-living agent composed of nucleic acid surrounded by a protein coat (A)</p> Signup and view all the answers

What is the primary function of a virion?

<p>To infect the host cell and replicate inside it (D)</p> Signup and view all the answers

What is the difference between host range and tissue specificity in viruses?

<p>Host range refers to the organisms a virus can infect, while tissue specificity refers to the tissues a virus can infect (A)</p> Signup and view all the answers

Which of the following is NOT a mode of transmission for viruses?

<p>Transmission through the air (A)</p> Signup and view all the answers

What is the role of arthropods in viral transmission?

<p>They act as mechanical vectors, carrying the virus on the outside of their body and transmitting it through physical contact (D)</p> Signup and view all the answers

Which of the following is a characteristic of primary cell cultures?

<p>They require a secondary culture for sustained growth (A)</p> Signup and view all the answers

Which of the following is NOT a virus-like agent?

<p>Bacteriophages (C)</p> Signup and view all the answers

Which of the following is true about viroids?

<p>They are fragments of DNA that cause disease in crop plants (A)</p> Signup and view all the answers

Which of the following is true about virusoids?

<p>They require a helper virus for replication (C)</p> Signup and view all the answers

Which of the following is true about prions?

<p>They cause transmissible spongiform encephalopathies (C)</p> Signup and view all the answers

Which type of antiviral drug directly binds to reverse transcriptase and inhibits transcription, preventing synthesis of DNA in retroviruses?

<p>Reverse transcriptase inhibitors (A)</p> Signup and view all the answers

Which antiviral drug is used to treat respiratory syncytial virus (RSV)?

<p>Ribavirin (C)</p> Signup and view all the answers

Which antiviral drug blocks fusion of the HIV envelope with the host cell plasma membrane?

<p>Enfuvirtide (C)</p> Signup and view all the answers

Which antiviral drug prevents the development of Influenza A?

<p>Amantadine (D)</p> Signup and view all the answers

Which physical agent can inactivate viruses?

<p>Physical and chemical agents (A)</p> Signup and view all the answers

Which step in the one-step multiplication curve of a bacteriophage population involves the attachment of virions to host cells?

<p>Inoculation (A)</p> Signup and view all the answers

Which of the following best describes a virus?

<p>A submicroscopic, infectious, parasitic, non-living agent composed of nucleic acid surrounded by a protein coat (C)</p> Signup and view all the answers

What is the purpose of centrifugation or filtration in the isolation of viruses?

<p>To separate virions from host cells (B)</p> Signup and view all the answers

What is the primary function of a virion?

<p>To infect a host cell and take over its metabolic machinery (D)</p> Signup and view all the answers

Which type of cell culture has a limited life span and is prone to contact inhibition?

<p>Primary cell culture (A)</p> Signup and view all the answers

What is the host range of a virus?

<p>The range of hosts that a virus can infect (B)</p> Signup and view all the answers

Which step in the life cycle of T-even bacteriophage involves the degradation of the bacterial chromosome and synthesis of multiple copies of viral DNA?

<p>Eclipse (B)</p> Signup and view all the answers

How can viruses be transmitted from one host to another?

<p>All of the above (D)</p> Signup and view all the answers

What is the main reason why animal viruses require cells within a host animal or tissue-culture cells for cultivation?

<p>None of the above (D)</p> Signup and view all the answers

What is the role of reverse transcriptase in the replication of RNA viruses?

<p>To convert RNA into DNA (A)</p> Signup and view all the answers

Which step in the life cycle of animal viruses involves the fusion of the viral envelope with the plasma membrane of the host cell?

<p>Release (D)</p> Signup and view all the answers

Which type of animal virus requires the synthesis of a complementary strand before it can replicate its genome?

<p>DNA virus (A)</p> Signup and view all the answers

Which type of RNA virus must first use its negative-sense RNA as a template to synthesize positive-sense RNA before viral proteins can be synthesized?

<p>-ssRNA virus (C)</p> Signup and view all the answers

Which step in the viral growth curve is characterized by a very steep rise in viral titer, indicating the release of a large number of viral particles?

<p>Burst (A)</p> Signup and view all the answers

Which type of animal virus can enter a dormant phase within the host cell nucleus and reactivate under stress?

<p>Latent virus (B)</p> Signup and view all the answers

Which type of viruses have an envelope in addition to a capsid?

<p>Enveloped viruses (D)</p> Signup and view all the answers

Which step in the life cycle of T-even bacteriophage involves the degradation of the bacterial chromosome and synthesis of multiple copies of viral DNA?

<p>Biosynthesis (B)</p> Signup and view all the answers

What is the function of Neuraminidase (N) spike in the Influenza virus?

<p>Helps release virions from the host cell after replication and assembly (B)</p> Signup and view all the answers

What is the burst size in the context of a bacteriophage population?

<p>The number of bacteriophages released from a lysed bacterial cell (C)</p> Signup and view all the answers

Which enzyme do neuraminidase inhibitors target?

<p>Neuraminidase (C)</p> Signup and view all the answers

Which of the following is a characteristic of primary cell cultures?

<p>They require a secondary culture to sustain growth. (C)</p> Signup and view all the answers

Which of the following is NOT a characteristic of viroids?

<p>They take control of the host machinery to replicate their RNA genome. (B)</p> Signup and view all the answers

Which of the following is a characteristic of virusoids?

<p>They require a specific 'helper' virus to infect cells. (A)</p> Signup and view all the answers

Which of the following is true about prions?

<p>They are composed solely of protein and contain no nucleic acid. (A)</p> Signup and view all the answers

Which of the following is NOT a disease caused by prions?

<p>Rabies (C)</p> Signup and view all the answers

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