Bacterial Cell Wall Synthesis and Penicillin
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Questions and Answers

What is the primary function of clavulanic acid when used in combination with amoxicillin?

  • Targets Gram-negative bacteria
  • Acts as a beta-lactamase inhibitor (correct)
  • Enhances antibacterial activity
  • Reduces the spectrum of antibiotic activity
  • Why are glycopeptides unable to penetrate the outer membrane of Gram-negative bacteria?

  • They lack antibacterial activity
  • They are too small
  • They are not compatible with the membrane structure
  • They are too large (correct)
  • What is the spectrum of activity for glycopeptides?

  • Broad spectrum
  • Primarily against anaerobic bacteria
  • Limited to Gram-negative bacteria
  • Narrow spectrum (correct)
  • Which bacteria are primarily targeted by glycopeptides due to their multiple resistance to other agents?

    <p>Gram-positive cocci</p> Signup and view all the answers

    What is a common mechanism of resistance against glycopeptides reported in bacteria like MRSA?

    <p>Reduced sensitivity to glycopeptides</p> Signup and view all the answers

    In what bacterial strains are reports of resistance or reduced sensitivity to glycopeptides becoming more frequent?

    <p>Enterococci and staphylococci</p> Signup and view all the answers

    What makes clavulanic acid useful despite its poor antibacterial activity when used alongside amoxicillin?

    <p>Functions as a beta-lactamase inhibitor</p> Signup and view all the answers

    Why are glycopeptides ineffective against Gram-negative bacteria?

    <p>They are too large to penetrate the outer membrane</p> Signup and view all the answers

    What is the significance of glycopeptides' activity against Gram-positive cocci with multiple resistance?

    <p>They provide a new treatment option for resistant infections</p> Signup and view all the answers

    What type of bacteria exhibit increased reports of resistance or reduced sensitivity to glycopeptides?

    <p>Gram-positive cocci</p> Signup and view all the answers

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