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Questions and Answers
Where do B cells develop before maturing?
Where do B cells develop before maturing?
What do B cells recognize directly without the need for Antigen Presenting Cells?
What do B cells recognize directly without the need for Antigen Presenting Cells?
What is the primary function of B cells?
What is the primary function of B cells?
Which immune response do B cells primarily contribute to?
Which immune response do B cells primarily contribute to?
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What happens to B cells after activation by foreign antigens?
What happens to B cells after activation by foreign antigens?
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What are the long-lived survivors of previous infections called?
What are the long-lived survivors of previous infections called?
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What is secreted by effector B cells in response to antigens?
What is secreted by effector B cells in response to antigens?
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What is the process called when plasma B cells die after their function is completed?
What is the process called when plasma B cells die after their function is completed?
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Study Notes
B Cells
- Develop in lymph nodes and spleen
- Recognize free antigens
- Rely on Antigen Presenting Cells (unlike T cells)
- Primary function: produce antibodies
- Crucial role in the immune response, targeting foreign antigens
Antibody Response
- Primarily dependent on helper T cell involvement
- Activation by foreign antigens leads to:
- Plasma cells releasing antibodies
- Memory B cells formation
- Plasma cells are long-lived and maintain antibody production; these cells remember previous infections
- Memory B cells respond to re-exposure of particular antigens
- Antibodies: specialized proteins with unique antigen-binding properties, found on the surface of the original B cell
- Antibodies circulate in bodily fluids (blood, bile, etc.)
- Antigen binding leads to various actions:
- Agglutination
- Neutralization
- Immobilization
- Complement system activation
Plasma Cells
- Short-lived effector cells
- Do not exhibit antigen-binding receptors
Cell Death
- Plasma cells undergo apoptosis after a foreign agent is destroyed
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