B Cell Signaling Pathways Quiz
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Questions and Answers

Which type of receptors recognizes a ligand on a distinct cell and can influence transcription of specific target genes?

  • Non-receptor tyrosine kinase receptor
  • Nuclear receptor (correct)
  • Receptor tyrosine kinase receptor
  • G protein-coupled receptor
  • In T cell activation, what is the role of microRNA?

  • Promote B cell activation
  • Activate the JAK-STAT pathway
  • Enhance cytokine production
  • Regulate T cell activation (correct)
  • What is the function of complement in B cell activation?

  • Inhibit B cell activation
  • Support B cell activation (correct)
  • Enhance antigen presentation
  • Promote cytokine production
  • Which category of signalling receptors in the immune system uses a non-receptor tyrosine kinase?

    <p>Receptor tyrosine kinase</p> Signup and view all the answers

    How are cytokines and their receptors regulated?

    <p>Highly regulated expression</p> Signup and view all the answers

    What type of receptor is a seven-transmembrane G protein-coupled receptor in the immune system?

    <p>G protein-coupled receptor</p> Signup and view all the answers

    What is the role of non-receptor tyrosine kinases in cytokine signaling?

    <p>Activate downstream enzymes in the cytosolic phase</p> Signup and view all the answers

    How does a phosphotyrosine-containing receptor tail affect downstream signaling?

    <p>Facilitates the recruitment and activation of downstream enzymes</p> Signup and view all the answers

    Which domain in c-SRC mediates the binding to other signaling proteins?

    <p>SRC homology 2 (SH2) domain</p> Signup and view all the answers

    What is the role of complement in B cell activation?

    <p>Enhances microbial antigen binding to membrane immunoglobulin</p> Signup and view all the answers

    What is the function of a generic receptor that activates a non-receptor tyrosine kinase (NRTK)?

    <p>Activating an NRTK after ligand binding</p> Signup and view all the answers

    What role do non-receptor tyrosine kinases play in regulating cell functions?

    <p>Promoting cell growth and proliferation</p> Signup and view all the answers

    Which molecule plays a key role in terminating T cell responses?

    <p>CBL-b</p> Signup and view all the answers

    How does a modified transcription factor facilitate gene expression?

    <p>By binding to specific regions in the promoter or regulatory regions of target genes</p> Signup and view all the answers

    What happens after antigen-induced cross-linking of membrane immunoglobulin on B cells?

    <p>Clustering of SRC family tyrosine kinases</p> Signup and view all the answers

    Which process is initiated by engagement of microbial antigens with complement fragment C3d in B cells?

    <p>Initiation of signaling cascades from both B cell receptor complex and CR2 complex</p> Signup and view all the answers

    What follows the tyrosine phosphorylation of the ITAMs in the cytoplasmic tails of Igα and Igβ molecules on B cells?

    <p>Activation of transcription factors</p> Signup and view all the answers

    Which signaling receptors are involved in the immune system similar to those described in T cells?

    <p>NFAT and NF-κB</p> Signup and view all the answers

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