B Cell Signaling Pathways Quiz
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Questions and Answers

Which type of receptors recognizes a ligand on a distinct cell and can influence transcription of specific target genes?

  • Non-receptor tyrosine kinase receptor
  • Nuclear receptor (correct)
  • Receptor tyrosine kinase receptor
  • G protein-coupled receptor

In T cell activation, what is the role of microRNA?

  • Promote B cell activation
  • Activate the JAK-STAT pathway
  • Enhance cytokine production
  • Regulate T cell activation (correct)

What is the function of complement in B cell activation?

  • Inhibit B cell activation
  • Support B cell activation (correct)
  • Enhance antigen presentation
  • Promote cytokine production

Which category of signalling receptors in the immune system uses a non-receptor tyrosine kinase?

<p>Receptor tyrosine kinase (C)</p> Signup and view all the answers

How are cytokines and their receptors regulated?

<p>Highly regulated expression (A)</p> Signup and view all the answers

What type of receptor is a seven-transmembrane G protein-coupled receptor in the immune system?

<p>G protein-coupled receptor (D)</p> Signup and view all the answers

What is the role of non-receptor tyrosine kinases in cytokine signaling?

<p>Activate downstream enzymes in the cytosolic phase (D)</p> Signup and view all the answers

How does a phosphotyrosine-containing receptor tail affect downstream signaling?

<p>Facilitates the recruitment and activation of downstream enzymes (B)</p> Signup and view all the answers

Which domain in c-SRC mediates the binding to other signaling proteins?

<p>SRC homology 2 (SH2) domain (A)</p> Signup and view all the answers

What is the role of complement in B cell activation?

<p>Enhances microbial antigen binding to membrane immunoglobulin (C)</p> Signup and view all the answers

What is the function of a generic receptor that activates a non-receptor tyrosine kinase (NRTK)?

<p>Activating an NRTK after ligand binding (A)</p> Signup and view all the answers

What role do non-receptor tyrosine kinases play in regulating cell functions?

<p>Promoting cell growth and proliferation (B)</p> Signup and view all the answers

Which molecule plays a key role in terminating T cell responses?

<p>CBL-b (C)</p> Signup and view all the answers

How does a modified transcription factor facilitate gene expression?

<p>By binding to specific regions in the promoter or regulatory regions of target genes (C)</p> Signup and view all the answers

What happens after antigen-induced cross-linking of membrane immunoglobulin on B cells?

<p>Clustering of SRC family tyrosine kinases (C)</p> Signup and view all the answers

Which process is initiated by engagement of microbial antigens with complement fragment C3d in B cells?

<p>Initiation of signaling cascades from both B cell receptor complex and CR2 complex (B)</p> Signup and view all the answers

What follows the tyrosine phosphorylation of the ITAMs in the cytoplasmic tails of Igα and Igβ molecules on B cells?

<p>Activation of transcription factors (D)</p> Signup and view all the answers

Which signaling receptors are involved in the immune system similar to those described in T cells?

<p>NFAT and NF-κB (B)</p> Signup and view all the answers

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