B Cell Signaling Pathways Quiz

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Which type of receptors recognizes a ligand on a distinct cell and can influence transcription of specific target genes?

Non-receptor tyrosine kinase receptor

Nuclear receptor (correct)

Receptor tyrosine kinase receptor

G protein-coupled receptor

In T cell activation, what is the role of microRNA?

Promote B cell activation

Activate the JAK-STAT pathway

Enhance cytokine production

Regulate T cell activation (correct)

What is the function of complement in B cell activation?

Inhibit B cell activation

Support B cell activation (correct)

Enhance antigen presentation

Promote cytokine production

Which category of signalling receptors in the immune system uses a non-receptor tyrosine kinase?

Receptor tyrosine kinase Signup and view all the answers

How are cytokines and their receptors regulated?

Highly regulated expression Signup and view all the answers

What type of receptor is a seven-transmembrane G protein-coupled receptor in the immune system?

G protein-coupled receptor Signup and view all the answers

What is the role of non-receptor tyrosine kinases in cytokine signaling?

Activate downstream enzymes in the cytosolic phase Signup and view all the answers

How does a phosphotyrosine-containing receptor tail affect downstream signaling?

Facilitates the recruitment and activation of downstream enzymes Signup and view all the answers

Which domain in c-SRC mediates the binding to other signaling proteins?

SRC homology 2 (SH2) domain Signup and view all the answers

What is the role of complement in B cell activation?

Enhances microbial antigen binding to membrane immunoglobulin Signup and view all the answers

What is the function of a generic receptor that activates a non-receptor tyrosine kinase (NRTK)?

Activating an NRTK after ligand binding Signup and view all the answers

What role do non-receptor tyrosine kinases play in regulating cell functions?

Promoting cell growth and proliferation Signup and view all the answers

Which molecule plays a key role in terminating T cell responses?

CBL-b Signup and view all the answers

How does a modified transcription factor facilitate gene expression?

By binding to specific regions in the promoter or regulatory regions of target genes Signup and view all the answers

What happens after antigen-induced cross-linking of membrane immunoglobulin on B cells?

Clustering of SRC family tyrosine kinases Signup and view all the answers

Which process is initiated by engagement of microbial antigens with complement fragment C3d in B cells?

Initiation of signaling cascades from both B cell receptor complex and CR2 complex Signup and view all the answers

What follows the tyrosine phosphorylation of the ITAMs in the cytoplasmic tails of Igα and Igβ molecules on B cells?

Activation of transcription factors Signup and view all the answers

Which signaling receptors are involved in the immune system similar to those described in T cells?

NFAT and NF-κB Signup and view all the answers

B Cell Signaling Pathways Quiz

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