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12 Questions

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Signal Transduction in Cells

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Questions and Answers

What is the primary function of nuclear receptors?

To bind to hormones noncovalently and reversibly

To regulate cell migration and adhesion

To activate signaling systems

To directly affect gene transcription (correct)

What is the characteristic feature of serpentine receptors?

They are found intracellularly

They have 7 transmembrane spanning domains (correct)

They have a single transmembrane domain

They are linked to tyrosine kinase activity

What is the function of the tyrosine kinase region in RTKs?

Signal transduction

Phosphorylation of downstream targets (correct)

Regulation of cellular proliferation

Ligand binding

What is the characteristic feature of RTKs?

They have a large intracellular domain Signup and view all the answers

What is the primary function of TGF-β family receptors?

To induce and/or inhibit cellular proliferation or differentiation Signup and view all the answers

What is the function of type II receptors in TGF-β superfamily?

To phosphorylate the kinase domain of the type I partner Signup and view all the answers

What is the result of ion movements in the cell during signal propagation?

Changes in the electrical potential of the cells Signup and view all the answers

Which type of receptors have intrinsic enzymatic activity and are capable of autophosphorylation?

Receptors with intrinsic tyrosine kinase activity Signup and view all the answers

What is the outcome of protein phosphorylations during signal transduction?

Alteration in cellular activity and changes in the program of genes expressed Signup and view all the answers

Which of the following is an example of a receptor with intrinsic tyrosine phosphatase activity?

CD45 protein of T cells and macrophages Signup and view all the answers

What is the role of ligand-receptor interactions in signal transduction?

To couple many intracellular events Signup and view all the answers

What is the characteristic of plasmamembrane receptors that are coupled to G-proteins?

They are GTP-binding and hydrolysing proteins Signup and view all the answers