12 Questions
What is the primary function of nuclear receptors?
To directly affect gene transcription
What is the characteristic feature of serpentine receptors?
They have 7 transmembrane spanning domains
What is the function of the tyrosine kinase region in RTKs?
Phosphorylation of downstream targets
What is the characteristic feature of RTKs?
They have a large intracellular domain
What is the primary function of TGF-β family receptors?
To induce and/or inhibit cellular proliferation or differentiation
What is the function of type II receptors in TGF-β superfamily?
To phosphorylate the kinase domain of the type I partner
What is the result of ion movements in the cell during signal propagation?
Changes in the electrical potential of the cells
Which type of receptors have intrinsic enzymatic activity and are capable of autophosphorylation?
Receptors with intrinsic tyrosine kinase activity
What is the outcome of protein phosphorylations during signal transduction?
Alteration in cellular activity and changes in the program of genes expressed
Which of the following is an example of a receptor with intrinsic tyrosine phosphatase activity?
CD45 protein of T cells and macrophages
What is the role of ligand-receptor interactions in signal transduction?
To couple many intracellular events
What is the characteristic of plasmamembrane receptors that are coupled to G-proteins?
They are GTP-binding and hydrolysing proteins
Learn about the mechanisms of signal transduction in cells, including simple movement of signals and complex events involving ligand-receptor interactions, phosphorylations, and enzyme activations.
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