Signal Transduction in Cells

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Questions and Answers

What is the primary function of nuclear receptors?

  • To bind to hormones noncovalently and reversibly
  • To regulate cell migration and adhesion
  • To activate signaling systems
  • To directly affect gene transcription (correct)

What is the characteristic feature of serpentine receptors?

  • They are found intracellularly
  • They have 7 transmembrane spanning domains (correct)
  • They have a single transmembrane domain
  • They are linked to tyrosine kinase activity

What is the function of the tyrosine kinase region in RTKs?

  • Signal transduction
  • Phosphorylation of downstream targets (correct)
  • Regulation of cellular proliferation
  • Ligand binding

What is the characteristic feature of RTKs?

<p>They have a large intracellular domain (A)</p> Signup and view all the answers

What is the primary function of TGF-β family receptors?

<p>To induce and/or inhibit cellular proliferation or differentiation (A)</p> Signup and view all the answers

What is the function of type II receptors in TGF-β superfamily?

<p>To phosphorylate the kinase domain of the type I partner (D)</p> Signup and view all the answers

What is the result of ion movements in the cell during signal propagation?

<p>Changes in the electrical potential of the cells (B)</p> Signup and view all the answers

Which type of receptors have intrinsic enzymatic activity and are capable of autophosphorylation?

<p>Receptors with intrinsic tyrosine kinase activity (B)</p> Signup and view all the answers

What is the outcome of protein phosphorylations during signal transduction?

<p>Alteration in cellular activity and changes in the program of genes expressed (C)</p> Signup and view all the answers

Which of the following is an example of a receptor with intrinsic tyrosine phosphatase activity?

<p>CD45 protein of T cells and macrophages (D)</p> Signup and view all the answers

What is the role of ligand-receptor interactions in signal transduction?

<p>To couple many intracellular events (C)</p> Signup and view all the answers

What is the characteristic of plasmamembrane receptors that are coupled to G-proteins?

<p>They are GTP-binding and hydrolysing proteins (D)</p> Signup and view all the answers

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