18 Questions
Why is autotolerance important in the context of the immune system?
To prevent reaction to self antigens and avoid autoimmune diseases
Which type of tolerance may be induced by some microbes and tumors to evade the immune system?
Acquired tolerance
How does Ag-sequestration contribute to autotolerance?
By hiding antigens in locations like cornea and sperms
What is the central mechanism of B cell-tolerance?
Deletion of immature B cells recognizing self antigens with high affinity
How does central T cell tolerance contribute to autotolerance?
By deleting immature T cells recognizing antigens with high affinity in the thymus
Which purpose does autotolerance serve when it comes to autoimmune diseases?
Treating autoimmune diseases
What is the mechanism by which mature T cells become incapable of responding to self antigens in peripheral tissues?
Deletion due to repeated activation without co-stimulation
Which of the following is NOT a factor that helps in the induction of acquired tolerance?
Very high doses inducing tolerance
In autoimmune diseases, what is the cause of tissue damage?
Production of autoantibodies and auto-reactive T cells
Which factor does NOT contribute to autoimmunity?
Inhibition of Mph & DC function by Treg cells
What role do Auto Abs and auto-reactive T cells play in autoimmune diseases?
Causing tissue damage
Which of the following does NOT help in maintaining tolerance to an antigen?
Activation of T cells with co-stimulation
Which of the following is a key genetic factor contributing to the development of autoimmune diseases?
Inheritance of certain MHC alleles
What is the primary mechanism of tissue damage in most autoimmune diseases?
Type II cytotoxic reaction
Which of the following environmental factors can contribute to the development of autoimmune diseases?
Exposure to cross-reactive antigens
What is the role of T cells in the pathogenesis of autoimmune diseases?
T helper cells help B cells produce autoantibodies
Which of the following host factors can contribute to the development of autoimmune diseases?
Impaired T cell function
What is the role of hormonal factors in the etiology of autoimmune diseases?
Hormones stimulate the immune system and increase autoimmunity
Explore the host factors involved in the etiology of autoimmune diseases, focusing on immunological and genetic factors. Learn about B cells hyperactivity, T cells function, and the role of certain MHC alleles in autoimmune diseases.
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