Autoimmune Diseases: Host Factors in Etiology
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Questions and Answers

Why is autotolerance important in the context of the immune system?

  • To activate the immune system against foreign antigens
  • To enhance the response to self antigens and induce autoimmune diseases
  • To prevent reaction to self antigens and avoid autoimmune diseases (correct)
  • To target self antigens aggressively causing autoimmune diseases
  • Which type of tolerance may be induced by some microbes and tumors to evade the immune system?

  • Peripheral B-cell tolerance
  • Autoimmunity
  • Acquired tolerance (correct)
  • Central B-cell tolerance
  • How does Ag-sequestration contribute to autotolerance?

  • By presenting antigens in neural tissue
  • By activating T cells in peripheral tissues
  • By hiding antigens in locations like cornea and sperms (correct)
  • By exposing antigens to the immune system
  • What is the central mechanism of B cell-tolerance?

    <p>Deletion of immature B cells recognizing self antigens with high affinity</p> Signup and view all the answers

    How does central T cell tolerance contribute to autotolerance?

    <p>By deleting immature T cells recognizing antigens with high affinity in the thymus</p> Signup and view all the answers

    Which purpose does autotolerance serve when it comes to autoimmune diseases?

    <p>Treating autoimmune diseases</p> Signup and view all the answers

    What is the mechanism by which mature T cells become incapable of responding to self antigens in peripheral tissues?

    <p>Deletion due to repeated activation without co-stimulation</p> Signup and view all the answers

    Which of the following is NOT a factor that helps in the induction of acquired tolerance?

    <p>Very high doses inducing tolerance</p> Signup and view all the answers

    In autoimmune diseases, what is the cause of tissue damage?

    <p>Production of autoantibodies and auto-reactive T cells</p> Signup and view all the answers

    Which factor does NOT contribute to autoimmunity?

    <p>Inhibition of Mph &amp; DC function by Treg cells</p> Signup and view all the answers

    What role do Auto Abs and auto-reactive T cells play in autoimmune diseases?

    <p>Causing tissue damage</p> Signup and view all the answers

    Which of the following does NOT help in maintaining tolerance to an antigen?

    <p>Activation of T cells with co-stimulation</p> Signup and view all the answers

    Which of the following is a key genetic factor contributing to the development of autoimmune diseases?

    <p>Inheritance of certain MHC alleles</p> Signup and view all the answers

    What is the primary mechanism of tissue damage in most autoimmune diseases?

    <p>Type II cytotoxic reaction</p> Signup and view all the answers

    Which of the following environmental factors can contribute to the development of autoimmune diseases?

    <p>Exposure to cross-reactive antigens</p> Signup and view all the answers

    What is the role of T cells in the pathogenesis of autoimmune diseases?

    <p>T helper cells help B cells produce autoantibodies</p> Signup and view all the answers

    Which of the following host factors can contribute to the development of autoimmune diseases?

    <p>Impaired T cell function</p> Signup and view all the answers

    What is the role of hormonal factors in the etiology of autoimmune diseases?

    <p>Hormones stimulate the immune system and increase autoimmunity</p> Signup and view all the answers

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