Autacoids

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What are autacoids?

Autacoids are local chemical messengers involved in physiological and pathological processes.

Name two types of amine autacoids.

Histamine and 5-Hydroxytryptamine (Serotonin)

List three types of lipid-derived autacoids.

Prostaglandins, Leukotrienes, and Platelet activating factor

What are two examples of peptide autacoids?

Plasma kinins (Bradykinin and Kallidin) and Angiotensin

What are the pharmacological effects of histamine on blood vessels?

Histamine causes marked dilation of smaller blood vessels, including arterioles, capillaries, and venules.

Name two examples of heptahelical transmembrane molecules involved in transducing extracellular signals via G-proteins to intracellular second-messenger systems.

Histamine receptor subtypes

What are the pharmacological effects of histamine on blood vessels?

Marked dilation of smaller blood vessels including arterioles, capillaries, and venules

What is the subcutaneous action of histamine?

Blushed area, heat, increased heart rate and cardiac output, with little or no fall in BP

What is the intravenous action of histamine?

Fall in BP having a short-lasting H1 and a slow but more persistent H2 component

Name two examples of peptide autacoids.

Bradykinin, Kallidin

Test your knowledge on autacoids, the local chemical messengers involved in various physiological and pathological processes. Explore amine autacoids like histamine and serotonin, lipid-derived autacoids such as prostaglandins and leukotrienes, and peptide autacoids. Challenge yourself with this quiz!

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