Autacoids
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Questions and Answers

What are autacoids?

Autacoids are local chemical messengers involved in physiological and pathological processes.

Name two types of amine autacoids.

Histamine and 5-Hydroxytryptamine (Serotonin)

List three types of lipid-derived autacoids.

Prostaglandins, Leukotrienes, and Platelet activating factor

What are two examples of peptide autacoids?

<p>Plasma kinins (Bradykinin and Kallidin) and Angiotensin</p> Signup and view all the answers

What are the pharmacological effects of histamine on blood vessels?

<p>Histamine causes marked dilation of smaller blood vessels, including arterioles, capillaries, and venules.</p> Signup and view all the answers

Name two examples of heptahelical transmembrane molecules involved in transducing extracellular signals via G-proteins to intracellular second-messenger systems.

<p>Histamine receptor subtypes</p> Signup and view all the answers

What are the pharmacological effects of histamine on blood vessels?

<p>Marked dilation of smaller blood vessels including arterioles, capillaries, and venules</p> Signup and view all the answers

What is the subcutaneous action of histamine?

<p>Blushed area, heat, increased heart rate and cardiac output, with little or no fall in BP</p> Signup and view all the answers

What is the intravenous action of histamine?

<p>Fall in BP having a short-lasting H1 and a slow but more persistent H2 component</p> Signup and view all the answers

Name two examples of peptide autacoids.

<p>Bradykinin, Kallidin</p> Signup and view all the answers

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