Podcast
Questions and Answers
What is the primary mechanism of action of bupropion?
What is the primary mechanism of action of bupropion?
- Antagonism of central presynaptic alpha2 adrenergic receptors
- Inhibition of monoamine oxidase
- Inhibition of serotonin reuptake
- Weak inhibition of norepinephrine and dopamine reuptake (correct)
Which receptor antagonism is responsible for the sedative effects of mirtazapine?
Which receptor antagonism is responsible for the sedative effects of mirtazapine?
- 5-HT2 receptor antagonism
- 5-HT3 receptor antagonism
- Histamine (H1) receptor antagonism (correct)
- Alpha2 adrenergic receptor antagonism
What percentage of an orally administered dose of bupropion reaches systemic circulation?
What percentage of an orally administered dose of bupropion reaches systemic circulation?
- 50-80%
- 20-50%
- 5-20% (correct)
- 80-100%
Which of the following is an active metabolite of bupropion?
Which of the following is an active metabolite of bupropion?
What is the primary route of excretion for bupropion metabolites?
What is the primary route of excretion for bupropion metabolites?
What is the approximate protein binding of mirtazapine during distribution?
What is the approximate protein binding of mirtazapine during distribution?
What is the primary reason bupropion is contraindicated in patients with a seizure disorder?
What is the primary reason bupropion is contraindicated in patients with a seizure disorder?
Which enzyme is primarily responsible for the metabolism of mirtazapine?
Which enzyme is primarily responsible for the metabolism of mirtazapine?
What is the most common adverse effect experienced by patients taking mirtazapine?
What is the most common adverse effect experienced by patients taking mirtazapine?
Why should patients who abruptly stop taking their antiseizure medication avoid being prescribed bupropion?
Why should patients who abruptly stop taking their antiseizure medication avoid being prescribed bupropion?
Which condition is a known contraindication for bupropion use?
Which condition is a known contraindication for bupropion use?
What is the recommended starting dose of bupropion for Major Depressive Disorder (MDD)?
What is the recommended starting dose of bupropion for Major Depressive Disorder (MDD)?
Why is mirtazapine contraindicated within 14 days of taking MAOIs?
Why is mirtazapine contraindicated within 14 days of taking MAOIs?
