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Atypical Antidepressants: Bupropion and Mirtazapine

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Atypical Antidepressants: Bupropion and Mirtazapine

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Questions and Answers

What is the primary mechanism of action of bupropion?

Antagonism of central presynaptic alpha2 adrenergic receptors

Inhibition of monoamine oxidase

Inhibition of serotonin reuptake

Weak inhibition of norepinephrine and dopamine reuptake (correct)

Which receptor antagonism is responsible for the sedative effects of mirtazapine?

5-HT2 receptor antagonism

5-HT3 receptor antagonism

Histamine (H1) receptor antagonism (correct)

Alpha2 adrenergic receptor antagonism

What percentage of an orally administered dose of bupropion reaches systemic circulation?

50-80%

20-50%

5-20% (correct)

80-100%

Which of the following is an active metabolite of bupropion?

Hydroxybupropion Signup and view all the answers

What is the primary route of excretion for bupropion metabolites?

Urine (87%) Signup and view all the answers

What is the approximate protein binding of mirtazapine during distribution?

80-90% Signup and view all the answers

What is the primary reason bupropion is contraindicated in patients with a seizure disorder?

It can increase the risk of seizures Signup and view all the answers

Which enzyme is primarily responsible for the metabolism of mirtazapine?

CYP2D6 Signup and view all the answers

What is the most common adverse effect experienced by patients taking mirtazapine?

Drowsiness Signup and view all the answers

Why should patients who abruptly stop taking their antiseizure medication avoid being prescribed bupropion?

It could exacerbate seizure risk Signup and view all the answers

Which condition is a known contraindication for bupropion use?

Current or prior diagnosis of bulimia Signup and view all the answers

What is the recommended starting dose of bupropion for Major Depressive Disorder (MDD)?

$100 mg twice a day Signup and view all the answers

Why is mirtazapine contraindicated within 14 days of taking MAOIs?

Potential hypertensive crisis Signup and view all the answers