13 Questions
What is the primary mechanism of action of bupropion?
Weak inhibition of norepinephrine and dopamine reuptake
Which receptor antagonism is responsible for the sedative effects of mirtazapine?
Histamine (H1) receptor antagonism
What percentage of an orally administered dose of bupropion reaches systemic circulation?
5-20%
Which of the following is an active metabolite of bupropion?
Hydroxybupropion
What is the primary route of excretion for bupropion metabolites?
Urine (87%)
What is the approximate protein binding of mirtazapine during distribution?
80-90%
What is the primary reason bupropion is contraindicated in patients with a seizure disorder?
It can increase the risk of seizures
Which enzyme is primarily responsible for the metabolism of mirtazapine?
CYP2D6
What is the most common adverse effect experienced by patients taking mirtazapine?
Drowsiness
Why should patients who abruptly stop taking their antiseizure medication avoid being prescribed bupropion?
It could exacerbate seizure risk
Which condition is a known contraindication for bupropion use?
Current or prior diagnosis of bulimia
What is the recommended starting dose of bupropion for Major Depressive Disorder (MDD)?
$100 mg twice a day
Why is mirtazapine contraindicated within 14 days of taking MAOIs?
Potential hypertensive crisis
This quiz covers the key information about atypical antidepressants, focusing on bupropion (Wellbutrin, Zyban) and mirtazapine (Remeron). Learn about their pharmacodynamics and mechanisms of action for treating depression.
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