Attenuated Live Vaccines
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Questions and Answers

What is the result of receiving an attenuated vaccine?

  • Severe symptoms compared to actual infections
  • Sub-clinical disease with symptoms less intensive compared to actual infections (correct)
  • No response to the vaccine
  • Full-blown disease with severe symptoms
  • How has biotechnology been used to attenuate pathogens?

  • By increasing their virulence
  • By deleting all genes
  • By duplicating their genetic material
  • By adding or 'knocking out' a gene (correct)
  • Why are mutants ideal as vaccines?

  • They cause severe symptoms
  • They are difficult to produce
  • They mimic the natural infection process without causing severe symptoms (correct)
  • They elicit a weak immune response
  • What is an advantage of attenuated live vaccines?

    <p>Increased immunogenicity and production of memory</p> Signup and view all the answers

    What is the purpose of selectively deleting or mutating genes in pathogens?

    <p>To weaken the organism</p> Signup and view all the answers

    What is the outcome of using mutants as vaccines?

    <p>Durable immune response</p> Signup and view all the answers

    Study Notes

    Attenuated Live Vaccines

    • Attenuated live vaccines consist of weakened or attenuated organisms that can proliferate and provide a continuous antigen to the host.
    • People who receive attenuated vaccines develop sub-clinical disease, with symptoms that are less intensive compared to actual infections.
    • Mutants or non-virulent organisms are ideal as vaccines because they mimic the natural infection process without causing the same type of symptoms.
    • Biotechnology is used to attenuate pathogens by adding or “knocking out” a gene in these organisms, making them weaker.

    Advantages

    • Attenuated live vaccines have increased immunogenicity and production of memory cells.
    • They provide a continuous source of antigen, which elicits a durable immune response.

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    Description

    Learn about attenuated live vaccines, how they work, and their benefits in providing a durable immune response. Discover the role of mutants and non-virulent organisms in vaccine development.

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