6 Questions
What is the result of receiving an attenuated vaccine?
Sub-clinical disease with symptoms less intensive compared to actual infections
How has biotechnology been used to attenuate pathogens?
By adding or 'knocking out' a gene
Why are mutants ideal as vaccines?
They mimic the natural infection process without causing severe symptoms
What is an advantage of attenuated live vaccines?
Increased immunogenicity and production of memory
What is the purpose of selectively deleting or mutating genes in pathogens?
To weaken the organism
What is the outcome of using mutants as vaccines?
Durable immune response
Study Notes
Attenuated Live Vaccines
- Attenuated live vaccines consist of weakened or attenuated organisms that can proliferate and provide a continuous antigen to the host.
- People who receive attenuated vaccines develop sub-clinical disease, with symptoms that are less intensive compared to actual infections.
- Mutants or non-virulent organisms are ideal as vaccines because they mimic the natural infection process without causing the same type of symptoms.
- Biotechnology is used to attenuate pathogens by adding or “knocking out” a gene in these organisms, making them weaker.
Advantages
- Attenuated live vaccines have increased immunogenicity and production of memory cells.
- They provide a continuous source of antigen, which elicits a durable immune response.
Learn about attenuated live vaccines, how they work, and their benefits in providing a durable immune response. Discover the role of mutants and non-virulent organisms in vaccine development.
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