Podcast
Questions and Answers
What is the name of the medication?
What is the name of the medication?
What class of drug is Atorvastatin?
What class of drug is Atorvastatin?
Antilipemic agent, HMG-CoA reductase inhibitor (statin)
What is the usual dose range for adults taking Atorvastatin?
What is the usual dose range for adults taking Atorvastatin?
10-40 mg per day, may increase up to 80 mg/day
Usual side effects of Atorvastatin include back pain and _____
Usual side effects of Atorvastatin include back pain and _____
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Which symptom must be monitored while taking Atorvastatin?
Which symptom must be monitored while taking Atorvastatin?
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What is the primary reason patients take Atorvastatin?
What is the primary reason patients take Atorvastatin?
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Grapefruit juice may increase the risk of myopathy with Atorvastatin.
Grapefruit juice may increase the risk of myopathy with Atorvastatin.
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What pregnancy category is Atorvastatin classified under?
What pregnancy category is Atorvastatin classified under?
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Study Notes
Atorvastatin Overview
- Atorvastatin is commonly known by the brand name Lipitor.
- It is classified as an antilipemic agent, specifically an HMG-CoA reductase inhibitor (statin).
Mechanism of Action
- Inhibits HMG-CoA reductase, crucial for hepatic cholesterol production.
- Increases the number of LDL (low-density lipoprotein) receptors, leading to enhanced uptake and catabolism of LDL cholesterol, thereby reducing its levels.
- Increases HDL (high-density lipoprotein) cholesterol levels in the blood.
- Also promotes increased production of triglycerides.
Dosage Information
- Recommended dosage ranges from 10 to 40 mg taken once daily.
- Dosage may be escalated up to 80 mg/day if needed.
- For pediatric patients, the typical dosage is between 10 and 20 mg/day.
Side Effects
- Common side effects include:
- Musculoskeletal: back pain, myalgia, asthenia, and risk of rhabdomyolysis.
- Central Nervous System: headaches.
- Gastrointestinal: abdominal pain, constipation, diarrhea, dyspepsia, flatulence, and increased liver enzyme levels.
- Respiratory: sinusitis and pharyngitis.
Serious Side Effects to Monitor
- Look for symptoms of muscle pain, tenderness, or weakness, especially in conjunction with fever or malaise, and monitor Creatine Phosphokinase (CPK) levels.
- Discontinue atorvastatin if CPK levels are markedly elevated or if myopathy is suspected.
- Yellowing of the skin or eyes may indicate liver issues.
- Be alert for severe stomach pain accompanied by nausea/vomiting or loss of appetite.
- Monitor for skin rashes or hives.
Indication for Use
- Atorvastatin is primarily prescribed to reduce levels of LDL cholesterol.
Important Nursing Considerations
- Caution is advised when atorvastatin is used alongside digoxin.
- Grapefruit juice consumption can heighten the risk of myopathy and rhabdomyolysis.
- Classified as Pregnancy Category X, indicating teratogenic risks.
- Potential adverse interactions with medications such as erythromycin, niacin, antifungals, and oral contraceptives should be monitored.
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Description
This quiz covers atorvastatin, widely known as Lipitor, detailing its function as an HMG-CoA reductase inhibitor. It explores its mechanism of action, recommended dosages, and common side effects. Test your knowledge on this essential antilipemic agent.
