Atherosclerosis Risk Factors

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Questions and Answers

What is the result of severe and permanent reductions in blood flow to cells?

  • Hypertrophy
  • Hyperplasia
  • Metaplasia
  • Ischemic necrosis (correct)

Where are certain sites more vulnerable to the development of atherosclerosis?

  • Places with low oxygen levels
  • Regions with smooth vessel walls
  • Locations where arteries bifurcate or branch into smaller vessels (correct)
  • Areas with high blood flow

In which part of the vascular system can atherosclerosis develop?

  • Anywhere along the course of the artery (correct)
  • Mainly in the abdominal region
  • Only in the upper extremities
  • Exclusively in the lower extremities

What results from prolonged hemodynamic forces according to the reaction-to-injury theory?

<p>Vascular endothelial cell injury (A)</p> Signup and view all the answers

What replaces cells that undergo ischemic necrosis due to severe and permanent reductions in blood flow?

<p>Fibrous tissues (C)</p> Signup and view all the answers

What has hyperhomocysteinemia been positively correlated with?

<p>Peripheral and coronary artery disease (C)</p> Signup and view all the answers

How does homocysteine promote coagulation?

<p>By increasing factor V and factor XI activity (C)</p> Signup and view all the answers

What is the effect of folic acid and vitamin B12 on serum homocysteine levels?

<p>They decrease serum homocysteine levels (A)</p> Signup and view all the answers

What is the impact of B complex vitamins on reducing adverse cardiovascular events?

<p>They have no impact on adverse cardiovascular events (B)</p> Signup and view all the answers

Why is the use of B complex vitamins not recommended to reduce cardiovascular disease in patients with PAD?

<p>Because there are no data demonstrating that this therapy reduces adverse cardiovascular events (A)</p> Signup and view all the answers

What are fatty streaks composed of?

<p>Lipids and elongated smooth muscle cells (C)</p> Signup and view all the answers

Where are fatty streaks predominantly found?

<p>Coronary, popliteal, and internal carotid arteries (C)</p> Signup and view all the answers

Do fatty streaks usually cause clinical symptoms?

<p>No, they do not usually cause clinical symptoms (C)</p> Signup and view all the answers

Are fatty streaks reversible?

<p>Reversibility is uncertain (A)</p> Signup and view all the answers

What stimulates the development of collateral circulation in response to gradual narrowing of the arterial lumen?

<p>Gradual narrowing of the arterial lumen (B)</p> Signup and view all the answers

What is the impact of nicotine on blood flow and heart rate?

<p>Decreases blood flow to the extremities and increases heart rate (A)</p> Signup and view all the answers

How does carbon monoxide affect the tissues?

<p>Deprives the tissues of oxygen by combining readily with hemoglobin (B)</p> Signup and view all the answers

What is the impact of smoking on high-density lipoprotein (HDL) levels?

<p>Decreases HDL levels (B)</p> Signup and view all the answers

How is the use of tobacco related to the extent of the disease?

<p>Tobacco use increases the extent of the disease (C)</p> Signup and view all the answers

What is the effect of cessation of nicotine product use on disease risk?

<p>It reduces the risk of disease (C)</p> Signup and view all the answers

What are fibrous plaques composed of?

<p>Smooth muscle cells and collagen fibers (B)</p> Signup and view all the answers

Where are fibrous plaques predominantly found?

<p>In the abdominal aorta and coronary arteries (D)</p> Signup and view all the answers

What color are fibrous plaques?

<p>White to white-yellow (C)</p> Signup and view all the answers

What is the main effect of gradual narrowing of the arterial lumen?

<p>Development of collateral circulation (C)</p> Signup and view all the answers

What is the role of collateral circulation?

<p>To reroute blood flow around blockages (D)</p> Signup and view all the answers

What is the composition of fatty streaks?

<p>Lipids and elongated smooth muscle cells (A)</p> Signup and view all the answers

What is the main difference between arteriosclerosis and atherosclerosis?

<p>Arteriosclerosis involves the accumulation of lipids, calcium, blood components, and fibrous tissue, while atherosclerosis involves thickening of the muscle fibers and endothelial lining of artery walls. (C)</p> Signup and view all the answers

In what way do arteriosclerosis and atherosclerosis commonly coexist?

<p>They both rarely occur without the other and are often used interchangeably. (B)</p> Signup and view all the answers

What are the common direct results of atherosclerosis in arteries?

<p>Obstruction by thrombosis, aneurysm, ulceration, and rupture (C)</p> Signup and view all the answers

Why are all actively functioning tissue cells sensitive to any reduction in the supply of nutrients and oxygen?

<p>Because they require an abundant supply of nutrients and oxygen for their functioning (C)</p> Signup and view all the answers

What is the characteristic feature of atheromas or plaques?

<p>Accumulation of lipids, calcium, blood components, carbohydrates, and fibrous tissue (D)</p> Signup and view all the answers

What is the impact of diabetes on the risk of peripheral artery disease (PAD)?

<p>It increases the risk two- to fourfold, with higher amputation rates. (A)</p> Signup and view all the answers

How does diabetes affect the onset and progression of peripheral artery disease (PAD) compared to patients without diabetes?

<p>It causes earlier onset and more rapid progression of PAD. (A)</p> Signup and view all the answers

What are some factors contributing to the multifactorial impact of diabetes on atherosclerosis?

<p>Promotion of coagulation and derangement of cell types within vessel walls (A)</p> Signup and view all the answers

What is the significance of slightly increased serum CRP levels in relation to cardiovascular inflammation?

<p>They are associated with an increased risk of vascular damage when accompanied by other risk factors. (C)</p> Signup and view all the answers

How does diabetes impact the anatomic distribution of pathology in peripheral artery disease (PAD)?

<p>It causes greater severity of disease in the profunda femoris and all segments below the knee. (D)</p> Signup and view all the answers

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