12 Questions
What is the primary mechanism of action of sulfonylureas?
Stimulation of insulin release by blocking ATP-sensitive K+ channels
Which sulfonylurea has the shortest half-life?
Glipizide
What adverse effect is commonly associated with sulfonylureas?
Hypoglycemia
Which sulfonylurea has minimal transfer across the placenta and can be used as an alternative to insulin during pregnancy?
Glyburide
In which conditions should sulfonylureas be used with caution due to the risk of hypoglycemia?
Hepatic insufficiency
What distinguishes Meglitidines from Sulfonylureas in terms of duration of action?
Shorter duration of action
Which of the following statements about Metformin is true?
Metformin reduces LDL and VLDL levels
What is a common side effect of α-glucosidase inhibitors like Acarbose and Miglitol?
Flatulence and diarrhea
Why should Acarbose and Miglitol be used with caution in combination with insulin secretagogues or insulin?
They may cause hypoglycemia
What distinguishes Biguanides like Metformin from Sulfonylureas in terms of their mechanism of action?
Do not induce hypoglycemia
Which group of medications is contraindicated in patients with irritable or inflammatory bowel disease?
Alpha-glucosidase inhibitors like Acarbose and Miglitol
What is a risk factor for hypoglycemia associated with Insulin Sensitizers like Metformin?
Delayed or skipped meals
Learn about the mechanisms of action of sulfonylureas including stimulation of insulin release, reduction in hepatic glucose production, and increase in insulin sensitivity. Explore their pharmacokinetics which involves oral administration, liver metabolism, and excretion through the liver or kidney.
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