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Questions and Answers
What is the usual dose of Astorvastin (Lipitor)?
What is the usual dose of Astorvastin (Lipitor)?
- 40 mg once a day
- 5-10 mg once a day
- 10-20 mg once a day (correct)
- 20-30 mg twice a day
What therapeutic classification does Astorvastin (Lipitor) fall under?
What therapeutic classification does Astorvastin (Lipitor) fall under?
Lipid-lowering agent
What is the primary action of Astorvastin (Lipitor)?
What is the primary action of Astorvastin (Lipitor)?
Inhibits HMG-CoA reductase
Which of the following are common adverse reactions to Astorvastin (Lipitor)?
Which of the following are common adverse reactions to Astorvastin (Lipitor)?
What should be monitored if a patient on Astorvastin (Lipitor) develops muscle tenderness?
What should be monitored if a patient on Astorvastin (Lipitor) develops muscle tenderness?
Match the following nursing implications for Astorvastin (Lipitor):
Match the following nursing implications for Astorvastin (Lipitor):
What is one of the goals of evaluating a patient on Astorvastin (Lipitor)?
What is one of the goals of evaluating a patient on Astorvastin (Lipitor)?
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Study Notes
Astorvastin (Lipitor) Overview
- Usual dose for oral administration is 10-20 mg once daily.
Classifications
- Therapeutic classification: Lipid-lowering agent
- Pharmaceutical classification: HMG-CoA Reductase Inhibitors/Statins
- Indications primarily include the prevention of coronary disease.
Mechanism of Action & Therapeutic Effects
- Works by inhibiting HMG-CoA reductase, a key enzyme in cholesterol synthesis.
- Therapeutic effects include lowering total cholesterol, LDL cholesterol, and triglycerides.
- Reduces risk of myocardial infarction (MI) and slows progression of coronary atherosclerosis.
Adverse Reactions and Side Effects
- Serious adverse reactions: Rhabdomyolysis (muscle fiber breakdown releasing myoglobin into the bloodstream) and angioneurotic edema (hypersensitivity reaction).
- Common side effects: Headache, abdominal pain, constipation, diarrhea, gas, and heartburn.
- Contraindications include hypersensitivity, active liver disease, potential fetal abnormalities, and possibility of transferring through breast milk.
Nursing Implications
- Collect dietary history, focusing on fat intake.
- Evaluate and monitor cholesterol and triglyceride levels.
- Regularly assess liver function tests.
- Monitor CPK levels if the patient experiences muscle tenderness.
Evaluation Parameters
- Assess cholesterol and triglyceride levels regularly.
- Monitor for decreased LDL and total cholesterol levels.
- Look for an increase in HDL cholesterol.
- Track a decrease in triglyceride levels.
- Evaluate the effectiveness in slowing the progression of coronary artery disease.
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