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Questions and Answers
What is the primary role of catalysts in aspirin preparation?
What is the primary role of catalysts in aspirin preparation?
- To improve the yield and selectivity of the reaction (correct)
- To facilitate the formation of by-products
- To increase the reaction temperature
- To reduce the reaction time
What is the purpose of acetylation in aspirin preparation?
What is the purpose of acetylation in aspirin preparation?
- To reduce the melting point of aspirin
- To remove impurities from salicylic acid
- To increase the solubility of aspirin in water
- To convert salicylic acid into aspirin (correct)
What is the typical temperature range for the acetylation reaction in aspirin preparation?
What is the typical temperature range for the acetylation reaction in aspirin preparation?
- 100-110°C
- 80-90°C
- 150-160°C
- 130-140°C (correct)
What is the purpose of recrystallization in the purification of aspirin?
What is the purpose of recrystallization in the purification of aspirin?
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What is the typical pH range for the purification of aspirin?
What is the typical pH range for the purification of aspirin?
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Study Notes
Aspirin Preparation
Catalysts
- Aspirin preparation involves the use of catalysts to facilitate the reaction
- Common catalysts used:
- Sulfuric acid (H2SO4)
- Phosphoric acid (H3PO4)
- Zinc chloride (ZnCl2)
- Catalysts help to:
- Increase reaction rate
- Improve yield
- Enhance selectivity
Acetylation
- Aspirin preparation involves the acetylation of salicylic acid
- Acetylation reaction:
- Salicylic acid (C7H6O3) + Acetic anhydride (C4H6O3) → Aspirin (C9H8O4) + Acetic acid (C2H4O2)
- Acetylation conditions:
- Temperature: 130-140°C
- Time: 1-2 hours
- Solvent: Acetic anhydride
Purification
- Aspirin purification involves the removal of impurities and by-products
- Methods used:
- Recrystallization from ethanol or water
- Filtration
- Centrifugation
- Purification conditions:
- Temperature: 0-5°C
- Solvent: Ethanol or water
- pH: Neutral to slightly acidic
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