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Questions and Answers
Which type of hypersensitivity is associated with allergic bronchopulmonary aspergillosis (ABPA)?
Which type of hypersensitivity is associated with allergic bronchopulmonary aspergillosis (ABPA)?
- Type II hypersensitivity
- Type III hypersensitivity
- Type I hypersensitivity (correct)
- Type IV hypersensitivity
What is the characteristic of the branching pattern of Aspergillus?
What is the characteristic of the branching pattern of Aspergillus?
- Acute branching with septations (correct)
- Obtuse branching with septations
- Right-angled branching without septations
- Obtuse branching without septations
What is the name of the fruiting bodies produced by Aspergillus?
What is the name of the fruiting bodies produced by Aspergillus?
- Conidiophores (correct)
- Hyphae
- Sporangia
- Aspergillomas
Which of the following is a characteristic of aspergillomas?
Which of the following is a characteristic of aspergillomas?
What is the name of the antifungal medication used to treat less serious Aspergillus infections?
What is the name of the antifungal medication used to treat less serious Aspergillus infections?
Which of the following conditions increases the susceptibility to aspergillosis?
Which of the following conditions increases the susceptibility to aspergillosis?
What is the primary source of fungal infection in humans?
What is the primary source of fungal infection in humans?
What is the typical location of aspergillomas in the lung?
What is the typical location of aspergillomas in the lung?
Which of the following is a risk factor for angioinvasive aspergillosis?
Which of the following is a risk factor for angioinvasive aspergillosis?
What is a common complication of invasive aspergillosis?
What is a common complication of invasive aspergillosis?
What is the association between peanuts and Aspergillus flavus?
What is the association between peanuts and Aspergillus flavus?
What is the characteristic morphology of Aspergillus?
What is the characteristic morphology of Aspergillus?
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Study Notes
Aspergillus Fumigatus
- Aspergillus has acute branching with septations
Risk Factors and Associations
- Peanuts are associated with aflatoxins produced by Aspergillus flavus
- Aflatoxins are also associated with grains
- Hepatocellular carcinoma is associated with Aspergillus infection
Infections and Clinical Features
- Allergic bronchopulmonary aspergillosis (ABPA) causes wheezing, fever, and migratory pulmonary infiltrate
- Susceptibility to aspergillosis increases with TB cavities
- Aspergillosis can cause aspergillomas, which are gravity-dependent and typically form at the bottom of cavities
Angioinvasive Aspergillosis
- Occurs in patients with neutropenia, often due to leukemia or lymphoma
- Invades blood vessels and surrounding tissues
- Can cause kidney failure, endocarditis, and ring-enhancing lesions in the brain
- Can invade nasal sinuses
Treatment
- Voriconazole is used for less serious infections
- Amphotericin B is used for angioinvasive disease
Diagnosis
- Histology is the best way to identify Aspergillus, characterized by 45-degree branching septae
Aspergillus Fumigatus
- Aspergillus has acute branching with septations
Risk Factors and Associations
- Peanuts are associated with aflatoxins produced by Aspergillus flavus
- Aflatoxins are also associated with grains
- Hepatocellular carcinoma is associated with Aspergillus infection
Infections and Clinical Features
- Allergic bronchopulmonary aspergillosis (ABPA) causes wheezing, fever, and migratory pulmonary infiltrate
- Susceptibility to aspergillosis increases with TB cavities
- Aspergillosis can cause aspergillomas, which are gravity-dependent and typically form at the bottom of cavities
Angioinvasive Aspergillosis
- Occurs in patients with neutropenia, often due to leukemia or lymphoma
- Invades blood vessels and surrounding tissues
- Can cause kidney failure, endocarditis, and ring-enhancing lesions in the brain
- Can invade nasal sinuses
Treatment
- Voriconazole is used for less serious infections
- Amphotericin B is used for angioinvasive disease
Diagnosis
- Histology is the best way to identify Aspergillus, characterized by 45-degree branching septae
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