12 Questions
Which type of hypersensitivity is associated with allergic bronchopulmonary aspergillosis (ABPA)?
Type I hypersensitivity
What is the characteristic of the branching pattern of Aspergillus?
Acute branching with septations
What is the name of the fruiting bodies produced by Aspergillus?
Conidiophores
Which of the following is a characteristic of aspergillomas?
They are gravity-dependent and found at the bottom of cavities
What is the name of the antifungal medication used to treat less serious Aspergillus infections?
Voriconazole
Which of the following conditions increases the susceptibility to aspergillosis?
Tuberculosis
What is the primary source of fungal infection in humans?
Inhaling spores from the environment
What is the typical location of aspergillomas in the lung?
At the base of the lung
Which of the following is a risk factor for angioinvasive aspergillosis?
Neutropenia from leukemia or lymphoma
What is a common complication of invasive aspergillosis?
Kidney failure
What is the association between peanuts and Aspergillus flavus?
Peanuts are a common food source contaminated with Aspergillus flavus
What is the characteristic morphology of Aspergillus?
Acute branching with septations
Study Notes
Aspergillus Fumigatus
- Aspergillus has acute branching with septations
Risk Factors and Associations
- Peanuts are associated with aflatoxins produced by Aspergillus flavus
- Aflatoxins are also associated with grains
- Hepatocellular carcinoma is associated with Aspergillus infection
Infections and Clinical Features
- Allergic bronchopulmonary aspergillosis (ABPA) causes wheezing, fever, and migratory pulmonary infiltrate
- Susceptibility to aspergillosis increases with TB cavities
- Aspergillosis can cause aspergillomas, which are gravity-dependent and typically form at the bottom of cavities
Angioinvasive Aspergillosis
- Occurs in patients with neutropenia, often due to leukemia or lymphoma
- Invades blood vessels and surrounding tissues
- Can cause kidney failure, endocarditis, and ring-enhancing lesions in the brain
- Can invade nasal sinuses
Treatment
- Voriconazole is used for less serious infections
- Amphotericin B is used for angioinvasive disease
Diagnosis
- Histology is the best way to identify Aspergillus, characterized by 45-degree branching septae
Aspergillus Fumigatus
- Aspergillus has acute branching with septations
Risk Factors and Associations
- Peanuts are associated with aflatoxins produced by Aspergillus flavus
- Aflatoxins are also associated with grains
- Hepatocellular carcinoma is associated with Aspergillus infection
Infections and Clinical Features
- Allergic bronchopulmonary aspergillosis (ABPA) causes wheezing, fever, and migratory pulmonary infiltrate
- Susceptibility to aspergillosis increases with TB cavities
- Aspergillosis can cause aspergillomas, which are gravity-dependent and typically form at the bottom of cavities
Angioinvasive Aspergillosis
- Occurs in patients with neutropenia, often due to leukemia or lymphoma
- Invades blood vessels and surrounding tissues
- Can cause kidney failure, endocarditis, and ring-enhancing lesions in the brain
- Can invade nasal sinuses
Treatment
- Voriconazole is used for less serious infections
- Amphotericin B is used for angioinvasive disease
Diagnosis
- Histology is the best way to identify Aspergillus, characterized by 45-degree branching septae
This quiz covers various aspects of Aspergillus fungi, including their characteristics, associated diseases, and food associations. Identify the different species and their connections to food and health.
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