Aromatase Inhibitors in Breast Cancer

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Questions and Answers

What is the effect of Tamoxifen on the endometrium, liver, bone, and cardiovascular system?

  • It has weak agonist actions (correct)
  • It has no effect
  • It acts as an antagonist
  • It acts as a partial agonist

What is Tamoxifen commonly used to treat?

  • Male infertility
  • Uterine cancer
  • ER+ breast cancer in pre- and post-menopausal women (correct)
  • Osteoporosis in postmenopausal women

What is a side effect of Tamoxifen?

  • Reducing the risk of osteoporosis
  • Reducing the risk of uterine cancer
  • Increasing the risk of osteoporosis
  • Increasing the risk of uterine cancer (correct)

What is the mechanism of action of Aromatase Inhibitors (AIs)?

<p>They block the synthesis of estrogen (A)</p> Signup and view all the answers

What is Raloxifene used to treat?

<p>Prevention and treatment of osteoporosis in postmenopausal women (C)</p> Signup and view all the answers

What is a characteristic of Raloxifene?

<p>It has estrogenic actions on bone and cardiovascular system (D)</p> Signup and view all the answers

What is the primary mechanism of action of antiestrogens in the body?

<p>Blocking the estrogen receptor (ER) (D)</p> Signup and view all the answers

Which type of antiestrogen is Fulvestrant?

<p>Pure ER antagonist (C)</p> Signup and view all the answers

What is the main use of antiestrogens in the treatment of breast cancer?

<p>Treating estrogen receptor-positive (ER+) breast cancer (A)</p> Signup and view all the answers

What is the mechanism of action of Aromatase Inhibitors (AIs)?

<p>Inhibiting estrogen biosynthesis (D)</p> Signup and view all the answers

Which of the following is NOT a medicinal use of antiestrogens?

<p>Treating diabetes (B)</p> Signup and view all the answers

What is the purpose of using antiestrogens as fertility drugs?

<p>To block the negative feedback inhibition of estradiol on gonadotrophic hormones (C)</p> Signup and view all the answers

What is the primary mechanism of action of exemestane?

<p>Structurally mimicking androstenedione (B)</p> Signup and view all the answers

Which of the following aromatase inhibitors is approved for the treatment of breast cancer?

<p>Exemestane (C)</p> Signup and view all the answers

What is the reason for using aromatase inhibitors in postmenopausal women?

<p>Estrogen is primarily produced in peripheral tissues (D)</p> Signup and view all the answers

What is the mechanism of action of letrozole and anastrozole?

<p>Reversibly binding to the heme of cytochrome P450 unit (A)</p> Signup and view all the answers

What is the effect of aromatase inhibitors on serum concentrations of estrone, estradiol, and estrone sulfate?

<p>Decrease serum concentrations (C)</p> Signup and view all the answers

What is the structural difference between exemestane and androstenedione?

<p>Additional double bond in position 1 and methylidene group in position 6 (A)</p> Signup and view all the answers

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