18 Questions
What is the effect of Tamoxifen on the endometrium, liver, bone, and cardiovascular system?
It has weak agonist actions
What is Tamoxifen commonly used to treat?
ER+ breast cancer in pre- and post-menopausal women
What is a side effect of Tamoxifen?
Increasing the risk of uterine cancer
What is the mechanism of action of Aromatase Inhibitors (AIs)?
They block the synthesis of estrogen
What is Raloxifene used to treat?
Prevention and treatment of osteoporosis in postmenopausal women
What is a characteristic of Raloxifene?
It has estrogenic actions on bone and cardiovascular system
What is the primary mechanism of action of antiestrogens in the body?
Blocking the estrogen receptor (ER)
Which type of antiestrogen is Fulvestrant?
Pure ER antagonist
What is the main use of antiestrogens in the treatment of breast cancer?
Treating estrogen receptor-positive (ER+) breast cancer
What is the mechanism of action of Aromatase Inhibitors (AIs)?
Inhibiting estrogen biosynthesis
Which of the following is NOT a medicinal use of antiestrogens?
Treating diabetes
What is the purpose of using antiestrogens as fertility drugs?
To block the negative feedback inhibition of estradiol on gonadotrophic hormones
What is the primary mechanism of action of exemestane?
Structurally mimicking androstenedione
Which of the following aromatase inhibitors is approved for the treatment of breast cancer?
Exemestane
What is the reason for using aromatase inhibitors in postmenopausal women?
Estrogen is primarily produced in peripheral tissues
What is the mechanism of action of letrozole and anastrozole?
Reversibly binding to the heme of cytochrome P450 unit
What is the effect of aromatase inhibitors on serum concentrations of estrone, estradiol, and estrone sulfate?
Decrease serum concentrations
What is the structural difference between exemestane and androstenedione?
Additional double bond in position 1 and methylidene group in position 6
This quiz covers the types of aromatase inhibitors, including exemestane, and their role in breast cancer treatment. Learn about the structure and function of steroidal and non-steroidal AIs.
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