Aromatase Inhibitors in Breast Cancer

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson
Download our mobile app to listen on the go
Get App

Questions and Answers

What is the effect of Tamoxifen on the endometrium, liver, bone, and cardiovascular system?

  • It has weak agonist actions (correct)
  • It has no effect
  • It acts as an antagonist
  • It acts as a partial agonist

What is Tamoxifen commonly used to treat?

  • Male infertility
  • Uterine cancer
  • ER+ breast cancer in pre- and post-menopausal women (correct)
  • Osteoporosis in postmenopausal women

What is a side effect of Tamoxifen?

  • Reducing the risk of osteoporosis
  • Reducing the risk of uterine cancer
  • Increasing the risk of osteoporosis
  • Increasing the risk of uterine cancer (correct)

What is the mechanism of action of Aromatase Inhibitors (AIs)?

<p>They block the synthesis of estrogen (A)</p> Signup and view all the answers

What is Raloxifene used to treat?

<p>Prevention and treatment of osteoporosis in postmenopausal women (C)</p> Signup and view all the answers

What is a characteristic of Raloxifene?

<p>It has estrogenic actions on bone and cardiovascular system (D)</p> Signup and view all the answers

What is the primary mechanism of action of antiestrogens in the body?

<p>Blocking the estrogen receptor (ER) (D)</p> Signup and view all the answers

Which type of antiestrogen is Fulvestrant?

<p>Pure ER antagonist (C)</p> Signup and view all the answers

What is the main use of antiestrogens in the treatment of breast cancer?

<p>Treating estrogen receptor-positive (ER+) breast cancer (A)</p> Signup and view all the answers

What is the mechanism of action of Aromatase Inhibitors (AIs)?

<p>Inhibiting estrogen biosynthesis (D)</p> Signup and view all the answers

Which of the following is NOT a medicinal use of antiestrogens?

<p>Treating diabetes (B)</p> Signup and view all the answers

What is the purpose of using antiestrogens as fertility drugs?

<p>To block the negative feedback inhibition of estradiol on gonadotrophic hormones (C)</p> Signup and view all the answers

What is the primary mechanism of action of exemestane?

<p>Structurally mimicking androstenedione (B)</p> Signup and view all the answers

Which of the following aromatase inhibitors is approved for the treatment of breast cancer?

<p>Exemestane (C)</p> Signup and view all the answers

What is the reason for using aromatase inhibitors in postmenopausal women?

<p>Estrogen is primarily produced in peripheral tissues (D)</p> Signup and view all the answers

What is the mechanism of action of letrozole and anastrozole?

<p>Reversibly binding to the heme of cytochrome P450 unit (A)</p> Signup and view all the answers

What is the effect of aromatase inhibitors on serum concentrations of estrone, estradiol, and estrone sulfate?

<p>Decrease serum concentrations (C)</p> Signup and view all the answers

What is the structural difference between exemestane and androstenedione?

<p>Additional double bond in position 1 and methylidene group in position 6 (A)</p> Signup and view all the answers

Flashcards are hidden until you start studying

More Like This

Use Quizgecko on...
Browser
Browser