Apoptosis Quiz
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Questions and Answers

What did the Nobel Prize in Physiology or Medicine 2002 recognize?

  • Discovery of apoptosis in C.elegans
  • Identification of necrotic cell characteristics
  • Genetic regulation of organ development and programmed cell death (correct)
  • Research on the lineage of all cells in C.elegans

    • What distinguishes apoptotic cells from necrotic cells?

  • Apoptotic cells spill their contents into their neighbors
  • Necrotic cells require a proteolytic cascade mediated by Caspases
  • Apoptotic cells die neatly, without damaging their neighbors (correct)
  • Necrotic cells have intact plasma membranes

    • What is the role of Caspase-9 in apoptosis?

  • It orchestrates the apoptosis program
  • It is an effector caspase
  • It is an initiator caspase (correct)
  • It activates the executioner caspases

    • What did the research on C.elegans contribute to understanding apoptosis?

    <p>It reconstructed the apoptotic pathway in worms</p> Signup and view all the answers

    Which caspase is an initiator caspase?

    <p>Caspase 8</p> Signup and view all the answers

    What triggers the assembly of an adaptor-protein complex in the apoptotic pathway?

    <p>A apoptotic signal</p> Signup and view all the answers

    Which pathway is signaled from outside the cell?

    <p>Extrinsic pathway</p> Signup and view all the answers

    What is the main function of Bcl2 proteins in the Intrinsic Pathway?

    <p>Regulating apoptosis</p> Signup and view all the answers

    What is the characteristic feature of ferroptosis?

    <p>Accumulation of oxidatively damaged phospholipids</p> Signup and view all the answers

    Which protein is responsible for activating caspases by oligomerizing into a huge complex called the apoptosome?

    <p>Apaf1</p> Signup and view all the answers

    What is the function of caspase inhibitor proteins called IAPs?

    <p>Prevent activation of some procaspases</p> Signup and view all the answers

    What is the role of cytochrome c in the apoptotic pathway?

    <p>Signal that activates the intrinsic pathway</p> Signup and view all the answers

    What is the main function of initiator caspases?

    <p>Activate effector caspases</p> Signup and view all the answers

    What is the function of the death-inducing signaling complex (DISC) in the extrinsic pathway?

    <p>Cluster and activate initiator caspases</p> Signup and view all the answers

    What is the main function of executioner caspases?

    <p>Cleaved and activated by initiator caspases</p> Signup and view all the answers

    What is the role of procaspases in the apoptotic pathway?

    <p>Synthesized as inactive precursors and activated by cleavage</p> Signup and view all the answers

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