16 Questions
What did the Nobel Prize in Physiology or Medicine 2002 recognize?
Genetic regulation of organ development and programmed cell death
What distinguishes apoptotic cells from necrotic cells?
Apoptotic cells die neatly, without damaging their neighbors
What is the role of Caspase-9 in apoptosis?
It is an initiator caspase
What did the research on C.elegans contribute to understanding apoptosis?
It reconstructed the apoptotic pathway in worms
Which caspase is an initiator caspase?
Caspase 8
What triggers the assembly of an adaptor-protein complex in the apoptotic pathway?
A apoptotic signal
Which pathway is signaled from outside the cell?
Extrinsic pathway
What is the main function of Bcl2 proteins in the Intrinsic Pathway?
Regulating apoptosis
What is the characteristic feature of ferroptosis?
Accumulation of oxidatively damaged phospholipids
Which protein is responsible for activating caspases by oligomerizing into a huge complex called the apoptosome?
Apaf1
What is the function of caspase inhibitor proteins called IAPs?
Prevent activation of some procaspases
What is the role of cytochrome c in the apoptotic pathway?
Signal that activates the intrinsic pathway
What is the main function of initiator caspases?
Activate effector caspases
What is the function of the death-inducing signaling complex (DISC) in the extrinsic pathway?
Cluster and activate initiator caspases
What is the main function of executioner caspases?
Cleaved and activated by initiator caspases
What is the role of procaspases in the apoptotic pathway?
Synthesized as inactive precursors and activated by cleavage
Test your knowledge of apoptosis and programmed cell death with this quiz! Explore the key discoveries and genetic regulation of organ development by Sydney Brenner, Robert Horvitz, and John E. Sulston, for which they were awarded the Nobel Prize in Physiology or Medicine in 200
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