Podcast
Questions and Answers
What did the Nobel Prize in Physiology or Medicine 2002 recognize?
What did the Nobel Prize in Physiology or Medicine 2002 recognize?
- Discovery of apoptosis in C.elegans
- Identification of necrotic cell characteristics
- Genetic regulation of organ development and programmed cell death (correct)
- Research on the lineage of all cells in C.elegans
What distinguishes apoptotic cells from necrotic cells?
What distinguishes apoptotic cells from necrotic cells?
- Apoptotic cells spill their contents into their neighbors
- Necrotic cells require a proteolytic cascade mediated by Caspases
- Apoptotic cells die neatly, without damaging their neighbors (correct)
- Necrotic cells have intact plasma membranes
What is the role of Caspase-9 in apoptosis?
What is the role of Caspase-9 in apoptosis?
- It orchestrates the apoptosis program
- It is an effector caspase
- It is an initiator caspase (correct)
- It activates the executioner caspases
What did the research on C.elegans contribute to understanding apoptosis?
What did the research on C.elegans contribute to understanding apoptosis?
Which caspase is an initiator caspase?
Which caspase is an initiator caspase?
What triggers the assembly of an adaptor-protein complex in the apoptotic pathway?
What triggers the assembly of an adaptor-protein complex in the apoptotic pathway?
Which pathway is signaled from outside the cell?
Which pathway is signaled from outside the cell?
What is the main function of Bcl2 proteins in the Intrinsic Pathway?
What is the main function of Bcl2 proteins in the Intrinsic Pathway?
What is the characteristic feature of ferroptosis?
What is the characteristic feature of ferroptosis?
Which protein is responsible for activating caspases by oligomerizing into a huge complex called the apoptosome?
Which protein is responsible for activating caspases by oligomerizing into a huge complex called the apoptosome?
What is the function of caspase inhibitor proteins called IAPs?
What is the function of caspase inhibitor proteins called IAPs?
What is the role of cytochrome c in the apoptotic pathway?
What is the role of cytochrome c in the apoptotic pathway?
What is the main function of initiator caspases?
What is the main function of initiator caspases?
What is the function of the death-inducing signaling complex (DISC) in the extrinsic pathway?
What is the function of the death-inducing signaling complex (DISC) in the extrinsic pathway?
What is the main function of executioner caspases?
What is the main function of executioner caspases?
What is the role of procaspases in the apoptotic pathway?
What is the role of procaspases in the apoptotic pathway?
