Podcast
Questions and Answers
What is the main target of APC/CCDH1?
What is the main target of APC/CCDH1?
- Emi1
- Mitotic cyclins (correct)
- S-phase cyclins
- CDK
What is the function of SCF in the cell cycle?
What is the function of SCF in the cell cycle?
- To inhibit CDK activity
- To promote entry into S-phase by degrading inhibitors of S-phase cyclins (correct)
- To regulate the metaphase to anaphase transition
- To degrade mitotic cyclins
What is the role of Emi1 in regulating APC/C?
What is the role of Emi1 in regulating APC/C?
- It degrades CDH1
- It phosphorylates CDK
- It inhibits APC/Ccdc20 (correct)
- It activates APC/Ccdc20
What is the result of APC/C-mediated degradation of mitotic cyclins?
What is the result of APC/C-mediated degradation of mitotic cyclins?
What is the function of the Origin Recognition Complex (ORC) in the cell cycle?
What is the function of the Origin Recognition Complex (ORC) in the cell cycle?
How do SCF and APC/C regulate each other?
How do SCF and APC/C regulate each other?
What is the function of APC/C when bound to CDC20?
What is the function of APC/C when bound to CDC20?
What is the role of Cohesin in the cell cycle?
What is the role of Cohesin in the cell cycle?
What is the function of Separase?
What is the function of Separase?
What is the role of SCF in the cell cycle?
What is the role of SCF in the cell cycle?
What is the function of APC/C when bound to CDH1?
What is the function of APC/C when bound to CDH1?
What is the role of E3 ligase complexes in the cell cycle?
What is the role of E3 ligase complexes in the cell cycle?
What is the primary role of CDKs in the cell cycle?
What is the primary role of CDKs in the cell cycle?
During which phase of the cell cycle is cyclin abundance increased through transcription and reduced through degradation?
During which phase of the cell cycle is cyclin abundance increased through transcription and reduced through degradation?
What is the function of ubiquitination complexes in the cell cycle?
What is the function of ubiquitination complexes in the cell cycle?
Which of the following is an example of a CDK substrate?
Which of the following is an example of a CDK substrate?
What is the primary function of the anaphase-promoting complex (APC/C) in the cell cycle?
What is the primary function of the anaphase-promoting complex (APC/C) in the cell cycle?
During which phase of the cell cycle do cells prepare to divide?
During which phase of the cell cycle do cells prepare to divide?
The polyubiquitination and subsequent degradation of mitotic ______ will render CDK inactive and trigger exit from mitosis.
The polyubiquitination and subsequent degradation of mitotic ______ will render CDK inactive and trigger exit from mitosis.
[Blank] phosphorylate and activate DNA replication factors (MCM, Cdt1..) which triggers formation of DNA replication forks.
[Blank] phosphorylate and activate DNA replication factors (MCM, Cdt1..) which triggers formation of DNA replication forks.
During S and G2 ______ inhibits APC/Ccdc20.
During S and G2 ______ inhibits APC/Ccdc20.
In anaphase ______ is activated by no longer interacting with Mad2, Bub1, and Bub3.
In anaphase ______ is activated by no longer interacting with Mad2, Bub1, and Bub3.
SCF promotes entry into S-phase by degrading ______ of S-phase cyclins.
SCF promotes entry into S-phase by degrading ______ of S-phase cyclins.
In metaphase ______ remains inactive.
In metaphase ______ remains inactive.
The ______ phase is a short period where cells prepare to divide.
The ______ phase is a short period where cells prepare to divide.
CDKs phosphorylate a wide variety of ______ that are different in each stage.
CDKs phosphorylate a wide variety of ______ that are different in each stage.
Cyclin abundance is increased through ______ and reduced through degradation.
Cyclin abundance is increased through ______ and reduced through degradation.
CDK activity is inhibited by ______ of CDK inhibitory proteins.
CDK activity is inhibited by ______ of CDK inhibitory proteins.
Nuclear Lamina is an example of a ______ substrate.
Nuclear Lamina is an example of a ______ substrate.
Cyclin-dependent kinases are major drivers of the ______ cycle.
Cyclin-dependent kinases are major drivers of the ______ cycle.
Sic1 is not present, ______ CDK can trigger DNA replication
Sic1 is not present, ______ CDK can trigger DNA replication
E3 ligase complexes, such as SCF and ______, regulate the cell cycle
E3 ligase complexes, such as SCF and ______, regulate the cell cycle
During ______, Kinetochores connect the centromeres of each sister chromatides with the microtubules of the mitotic spindle
During ______, Kinetochores connect the centromeres of each sister chromatides with the microtubules of the mitotic spindle
APC/C binds ______ which triggers polyubiquitination of Securin, the inhibitor of Separase
APC/C binds ______ which triggers polyubiquitination of Securin, the inhibitor of Separase
Sister chromatids are held together by ______, a protein ring complex that loads onto chromosomes before replication
Sister chromatids are held together by ______, a protein ring complex that loads onto chromosomes before replication
APC/C also binds ______ and phosphorylate a wide variety of targets that will trigger telophase and cytokinesis
APC/C also binds ______ and phosphorylate a wide variety of targets that will trigger telophase and cytokinesis
Match the following cell cycle regulators with their corresponding functions:
Match the following cell cycle regulators with their corresponding functions:
Match the following cell cycle regulators with their corresponding substrates:
Match the following cell cycle regulators with their corresponding substrates:
Match the following cell cycle phases with their corresponding events:
Match the following cell cycle phases with their corresponding events:
Match the following CDK regulators with their corresponding mechanisms:
Match the following CDK regulators with their corresponding mechanisms:
Match the following cell cycle regulators with their corresponding phase specificity:
Match the following cell cycle regulators with their corresponding phase specificity:
Match the following cell cycle regulators with their corresponding targets:
Match the following cell cycle regulators with their corresponding targets:
Match the following CDK inhibitors with their mode of action:
Match the following CDK inhibitors with their mode of action:
Match the following cell cycle phases with their corresponding CDK substrates:
Match the following cell cycle phases with their corresponding CDK substrates:
Match the following E3 ligase complexes with their cell cycle phase specificity:
Match the following E3 ligase complexes with their cell cycle phase specificity:
Match the following CDK regulators with their function:
Match the following CDK regulators with their function:
Match the following CDK substrates with their phase of regulation:
Match the following CDK substrates with their phase of regulation:
Match the following CDK inhibition mechanisms with their corresponding inhibitors:
Match the following CDK inhibition mechanisms with their corresponding inhibitors:
Match the following CDK substrates with their functions in the cell cycle:
Match the following CDK substrates with their functions in the cell cycle:
Match the following cell cycle phases with the primary events that occur during each phase:
Match the following cell cycle phases with the primary events that occur during each phase:
Match the following CDK regulation mechanisms with their functions:
Match the following CDK regulation mechanisms with their functions:
Match the following CDK inhibitors with their mechanisms of action:
Match the following CDK inhibitors with their mechanisms of action:
Match the following cell cycle regulators with their functions:
Match the following cell cycle regulators with their functions:
Match the following cell cycle phases with the specific CDK substrates that are phosphorylated during each phase:
Match the following cell cycle phases with the specific CDK substrates that are phosphorylated during each phase:
