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Antipsychotics and Dopamine Pathways Quiz

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Antipsychotics and Dopamine Pathways Quiz

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Questions and Answers

What are the effects of blocking D2R in the tuberoinfundibular pathway?

Increased prolactin secretion and gynaecomastia

How does blocking D2R in the nigrostriatal pathway lead to extrapyramidal side-effects?

It leads to extrapyramidal side-effects such as parkinsonism and tardive dyskinesia.

In which pathway does hypofunction of the dopaminergic system underlie negative symptoms?

Mesocortical pathway

What evidence supports the dopamine hypothesis of schizophrenia?

Amphetamine induces psychotic-like symptoms in patients, L-DOPA can induce psychosis in Parkinson's disease patients, and there are genetic associations with the dopaminergic system. Signup and view all the answers

What are the three main dopamine pathways in the brain?

Nigrostriatal pathway, Mesolimbic pathway, and Mesocortical pathway. Signup and view all the answers

What side effects can be caused by the blockade of dopamine D2 receptors by typical antipsychotic drugs, and why do they occur?

The side effects include sedation, and they occur due to the rich pharmacology of typical antipsychotics. Signup and view all the answers

What are the lecture outcomes related to schizophrenia symptoms and pathophysiology?

Recall the symptoms and current understanding of the pathophysiology of schizophrenia Signup and view all the answers

What are the lecture outcomes related to current antipsychotic drugs?

Recall the strengths and weaknesses of current antipsychotic drugs in clinical use Signup and view all the answers

What is the incidence of schizophrenia in the general population?

1% Signup and view all the answers

What is the percentage of incidence for schizophrenia if there is a family history?

6-17% Signup and view all the answers