Podcast
Questions and Answers
Which receptor is NOT typically blocked by first-generation antipsychotic medications?
Which receptor is NOT typically blocked by first-generation antipsychotic medications?
- Norepinephrine
- Serotonin (correct)
- Acetylcholine
- Dopamine (D2)
Which medication requires an EKG prior to administration?
Which medication requires an EKG prior to administration?
- Ziprasidone (Geodon) (correct)
- Quetiapine (Seroquel)
- Olanzapine (Zyprexa)
- Risperidone (Risperdal)
A patient on clozapine (Clozaril) needs regular monitoring of which of the following?
A patient on clozapine (Clozaril) needs regular monitoring of which of the following?
- Liver function tests
- Thyroid function tests
- Renal function tests
- Complete blood count (CBC) (correct)
Which of the following side effects is most concerning for male patients taking Benztropine (Cogentin)?
Which of the following side effects is most concerning for male patients taking Benztropine (Cogentin)?
Which medication is used off-label for sleep?
Which medication is used off-label for sleep?
Which medication must be taken with food of at least 300 calories for proper absorption?
Which medication must be taken with food of at least 300 calories for proper absorption?
A patient is prescribed Amitriptyline (Elavil). What important monitoring is needed for this prescription?
A patient is prescribed Amitriptyline (Elavil). What important monitoring is needed for this prescription?
Which of the following medications used to treat bipolar disorder might cause Steven-Johnson syndrome?
Which of the following medications used to treat bipolar disorder might cause Steven-Johnson syndrome?
Which medication is a Monoamine Oxidase Inhibitor (MAOI)?
Which medication is a Monoamine Oxidase Inhibitor (MAOI)?
Which food should be avoided when taking drugs that are Monoamine Oxidase Inhibitors (MAOI)?
Which food should be avoided when taking drugs that are Monoamine Oxidase Inhibitors (MAOI)?
A patient on Risperidone (Risperdal) reports breast development and lactation. What is the most likely cause?
A patient on Risperidone (Risperdal) reports breast development and lactation. What is the most likely cause?
Which medication is classified as a tricyclic antidepressant (TCA)?
Which medication is classified as a tricyclic antidepressant (TCA)?
Which of the following antipsychotics is known to lower white blood cell count (WBC)?
Which of the following antipsychotics is known to lower white blood cell count (WBC)?
A patient taking lithium carbonate (lithium) should be monitored for:
A patient taking lithium carbonate (lithium) should be monitored for:
What is the most common use of Benztropine (Cogentin)?
What is the most common use of Benztropine (Cogentin)?
What is the maximum dose for Quetiapine (Seroquel)?
What is the maximum dose for Quetiapine (Seroquel)?
A patient taking fluoxetine (Prozac) should be aware that this medication:
A patient taking fluoxetine (Prozac) should be aware that this medication:
Which of the following is a potential side effect of valproic acid (Depakote)?
Which of the following is a potential side effect of valproic acid (Depakote)?
What is the reason to use Disulfiram (Antabuse)?
What is the reason to use Disulfiram (Antabuse)?
What is the max dosage for Naltrexone (Revia)?
What is the max dosage for Naltrexone (Revia)?
What is the max dose for Disulfiram (Antabuse)?
What is the max dose for Disulfiram (Antabuse)?
First generation antipsychotic medications block what in the brain?
First generation antipsychotic medications block what in the brain?
Which first generation antipsychotic medication treats acute/chronic psychotic disorders and schizophrenia?
Which first generation antipsychotic medication treats acute/chronic psychotic disorders and schizophrenia?
Which first generation antipsychotic medication treats bipolar disorder (manic phase) and prevents nausea and vomiting?
Which first generation antipsychotic medication treats bipolar disorder (manic phase) and prevents nausea and vomiting?
Which first generation antipsychotic, medication prevents nausea and vomiting?
Which first generation antipsychotic, medication prevents nausea and vomiting?
What is the max dose for Aripiprazole (Abilify)
What is the max dose for Aripiprazole (Abilify)
Which medications are known as second generation antipsychotics?
Which medications are known as second generation antipsychotics?
Flashcards
First-generation antipsychotic action
First-generation antipsychotic action
First-generation antipsychotics block dopamine (D2), acetylcholine, histamine, and norepinephrine receptors in the brain and periphery.
Haloperidol Uses
Haloperidol Uses
Haloperidol is used for treating acute and chronic psychotic disorders and Schizophrenia spectrum disorders.
Aripiprazole (abilify) Use
Aripiprazole (abilify) Use
Aripiprazole treats positive and negative symptoms of schizophrenia.
Clozapine Side Effect
Clozapine Side Effect
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Risperidone Side Effects
Risperidone Side Effects
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MAOI Food Interaction
MAOI Food Interaction
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Lithium carbonate Treatment
Lithium carbonate Treatment
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Benztropine use
Benztropine use
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Anticholinergic Complications
Anticholinergic Complications
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Study Notes
- These are medications listed by class, medications, max dose, pharmacological action, therapeutic uses, and any noted complications
First-Generation Antipsychotics
- Haloperidol is a high-potency first-generation antipsychotic.
- First-generation antipsychotics block dopamine (D2), acetylcholine, histamine, and norepinephrine receptors in the brain and periphery.
- Haloperidol manages acute and chronic psychotic disorders and schizophrenia spectrum disorders.
- Fluphenazine treats bipolar disorder, primarily the manic phase, Tourette's disorder, and agitation.
- Fluphenazine also prevents nausea and vomiting by blocking dopamine in the chemoreceptor trigger zone of the medulla.
- Chlorpromazine prevents nausea and vomiting by blocking dopamine in the chemoreceptor trigger zone of the medulla.
Second-Generation Antipsychotics
- Aripiprazole's max dose isn't specified.
- Clozapine treats positive and negative symptoms of schizophrenia
- Clozapine may lower WBC and absolute neutrophil count (ANC).
- Lurasidone must be taken with 300 calories to treat bipolar depression.
- Quetiapine has a max dose of 800mg and requires blood glucose tests.
- Risperidone has a max dose of 16mg.
- Risperidone can cause gynomastia in males, and amenorrhea in females.
- Ziprasidone requires an EKG prior to administration.
EPS Treatment
- Benztropine and Trihexyphenidyl are for treating extrapyramidal symptoms (EPS),
- Benztropine and Trihexyphenidyl work to treat imbalance of dopamine and acetylcholine.
- Benztropine and Trihexyphenidyl can problematic for males with prostate issues.
- Trihexyphenidyl can cause dry mouth, nasal congestion, urinary issues, blurred vision, constipation, and mydriasis (eye pain/glaucoma).
Antidepressants (SSRIs, Selective Serotonin Inhibitors, Tricyclic, MAOIs, Novel)
- Fluoxetine's dose is 80 mg.
- Fluoxetine is a first-line agent to treat depression but takes 4-6 weeks to work.
- Amitriptyline is a second-line treatment for depression, monitor ABC's.
- MAOIs are third-line agents for depression.
- When taking MAOIs restrict tyramine intake (avoid red wine, beer, aged/smoked meats/cheeses, avocados, figs, soy sauce), and OTC medicines/natural supplements due to risk of hypertensive crisis.
- Mirtazapine's dose is 45mg
- Mirtazapine helps increase appetite.
- Trazodone is used off-label for sleep.
- Venlafaxine with an SSRI can treat depression and anxiety.
Mood Stabilizers
- Lithium carbonate's therapeutic range is 0.6-1.2 mEq/L.
- There is no antidote for lithium carbonate.
- Treat lithium carbonate overdose with gastric lavage.
- Patient can end up on dialysis.
- Lithium carbonate can cause fatigue, headache, impaired memory, ECG changes, weight gain, nausea, polyuria, and seizures.
- Carbamazepine is prescribed at 8-12 ug/ml.
- Effective for patients not responding to lithium or depakote.
- Can cause Steven Johnson syndrome.
- Valproic Acid doses are 50-100 ug/ml .
- Valproic Acid can cause hair loss, weight gain, tremors, and thrombocytopenia
Anxiolytics, Detoxification, and Abstinence
- Propranolol is an Anti-Anxiety medication.
- Disulfiram doses are 250 mg/day.
- Naltrexone doses are 50 mg/day.
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