E8911F50-FE3C-48E0-A0A0-27113D34A320.jpeg

# Phenothiazines - Prochlorperazine, Promethazine & Thiethylperazine - Phenothiazines are antipsychotics with potent antiemetic property due to $D_2$ antagonism and anti-maucarinic properties. - Sedative property due to anti-histaminic property. - Mainly used as anti-emetic in severe N&V...

# Phenothiazines - Prochlorperazine, Promethazine & Thiethylperazine - Phenothiazines are antipsychotics with potent antiemetic property due to $D_2$ antagonism and anti-maucarinic properties. - Sedative property due to anti-histaminic property. - Mainly used as anti-emetic in severe N&V - Main A/E: EPS, sedation, postural hypotension # Butyrophenones - Antipsychotic drugs, $D_2$ antagonists - Droperidol - Central $D_2$ antagonist - Main A/E: EPS, postural hypotension - QT prolongation may occur - Domperidone - Does not cross BBB, Only blocks $D_2$ in CTZ where BBB is leaky. - May be used in N&V due to Levodopa, without affecting its efficacy. - No EPS. - Used as antiemetic, prokinetic agent & for post partum lactation stimulation.