Antimicrobial Resistance Forms and Features Quiz

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Questions and Answers

What type of resistance involves chromosomic genetic support, affects almost all species strains, and existed before antibiotic use?

  • Acquired resistance
  • Transposon resistance
  • Intrinsic resistance (correct)
  • Plasmidic resistance

Which form of antimicrobial resistance affects a fraction of strains and increases with antibiotic use?

  • Conjugative resistance
  • Plasmidic resistance
  • Intrinsic resistance
  • Acquired resistance (correct)

What is the process by which genetic material is transferred between microbes to cause acquired resistance?

  • Transduction
  • Transformation
  • Conjugation (correct)
  • Replication

Which of the following is NOT a way in which alteration of the microbial genome occurs?

<p>Transduction (B)</p> Signup and view all the answers

What type of DNA sequences can move or be copied to other regions of the microbial genome?

<p>Transposons (D)</p> Signup and view all the answers

How can mutations arise to cause resistance in a strain?

<p>Spontaneous point mutations (B)</p> Signup and view all the answers

Which form of resistance involves circular 'mini chromosomes' replicating independently of chromosomal DNA?

<p>Plasmidic resistance (D)</p> Signup and view all the answers

'Intrinsic resistance' is characterized by which of the following?

<p>'Existed before antibiotic use.' (D)</p> Signup and view all the answers

How does Clavulanic acid inhibit beta-lactamases?

<p>By causing irreversible acylation of beta-lactamases (C)</p> Signup and view all the answers

What is the purpose of the minimum inhibitory concentration (MIC) test?

<p>To measure the smallest concentration of antibiotic that inhibits the growth of an organism. (B)</p> Signup and view all the answers

What is the main reason for Chloramphenicol resistance?

<p>Acylation by chloramphenicol acetyl transferases (CAT) (C)</p> Signup and view all the answers

What is one method used for the MIC test?

<p>Dilution in liquid broth (C)</p> Signup and view all the answers

Which of the following is a mechanism of resistance exhibited by microbes?

<p>Modifying the drug target (D)</p> Signup and view all the answers

Which process leads to resistance against Aminoglycosides?

<p>Modification like acetylation, phosphorylation, or nucleotide conjugation (D)</p> Signup and view all the answers

What is the mechanism of action of glycopeptides as antibacterials?

<p>Inhibition of bacterial cell membrane synthesis (A)</p> Signup and view all the answers

What type of resistance mechanism involves preventing antimicrobials from entering the microbe?

<p>Antimicrobial exclusion (C)</p> Signup and view all the answers

How does increased methyl groups contribute to drug resistance?

<p>By reducing drug penetration into bacterial cells (D)</p> Signup and view all the answers

Which enzyme is responsible for hydrolyzing the beta-lactam ring in penicillins?

<p>Beta-lactamases (B)</p> Signup and view all the answers

What are the properties of beta-lactamases in gram-positive bacteria?

<p>Inducible and extracellular (D)</p> Signup and view all the answers

How do beta-lactams combat beta-lactamases?

<p>By creating increased steric hindrance (B)</p> Signup and view all the answers

Which aspect describes the mechanism of resistance to glycopeptides in microbes?

<p>Replacement of D-Ala - D-Ala with D-Ala - D-Lac (B)</p> Signup and view all the answers

What is a feature of glycopeptide intrinsic resistance?

<p>Resistance conferred by precursors similar to acquired resistance (B)</p> Signup and view all the answers

How does trimethoprim resistance develop?

<p>Modification of the target enzyme DHFR (D)</p> Signup and view all the answers

What is a characteristic of glycopeptide acquired resistance?

<p>Resistance conferred through the production of 7 new polypeptides (A)</p> Signup and view all the answers

What is the key difference between the lytic and lysogenic cycles of bacteriophages?

<p>The lytic cycle results in the immediate lysis of the host cell, while the lysogenic cycle involves integration of the phage DNA into the bacterial chromosome. (C)</p> Signup and view all the answers

Why do bacteriophages as antibiotics need to be very specific?

<p>To ensure they only target harmful bacteria without affecting beneficial ones. (B)</p> Signup and view all the answers

What contributes to the increase in bacteria resistance to antibiotics?

<p>Overuse and misuse of antibiotics in human and veterinary medicine. (C)</p> Signup and view all the answers

Which mechanism is NOT a common way bacteria develop resistance to antibiotics?

<p>Use of broad-spectrum antibiotics only. (A)</p> Signup and view all the answers

How is antibiotic resistance spread controlled in bacteria?

<p>Proper hand hygiene and sanitation practices. (D)</p> Signup and view all the answers

Which statement accurately describes one way resistance is developed in bacteria?

<p>Resistance can be acquired through horizontal gene transfer from other resistant bacteria. (A)</p> Signup and view all the answers

Which factor is NOT a mechanism of bacterial resistance to antibiotics?

<p>'Good' vs. 'bad' strains within the same species. (C)</p> Signup and view all the answers

What action contributes to reducing antibiotic resistance?

<p>'Rotating' antibiotics - changing them often to prevent resistance buildup. (D)</p> Signup and view all the answers

What impact does prophage excision have on bacterial chromosomes?

<p>It initiates a lytic cycle causing cell lysis. (A)</p> Signup and view all the answers

How does methicillin cause drug target bypass?

<p>By increasing the production of the target enzyme not affected by penicillins. (C)</p> Signup and view all the answers

What does it mean when microbes use enhanced target production to resist drugs?

<p>Microbes increase the production of the drug target. (E)</p> Signup and view all the answers

What is one way that efflux pumps contribute to drug resistance?

<p>By pumping antibiotics out of the cell. (D)</p> Signup and view all the answers

What is one example of drug resistance in fungi?

<p>Resistance to azole antifungals (D)</p> Signup and view all the answers

What is a resistome?

<p>A collection of antimicrobial resistance genes (A)</p> Signup and view all the answers

How can antifolates cause drug target bypass?

<p>By developing an alternative route for folic acid biosynthesis. (A)</p> Signup and view all the answers

What are efflux pumps, where are they located, and what do they require?

<p>Transporter proteins that pump things out of the cell, located in the cytoplasmic membrane, requiring ATP or potential difference for function. (B)</p> Signup and view all the answers

In what way do microbes do a drug target bypass?

<p>By developing alternative mechanisms that side-step key steps in antibiotic action. (B)</p> Signup and view all the answers

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