Antimicrobial Combination Therapy
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Questions and Answers

What is the mechanism observed in the imipenem-colistin combination at low crestor concentrations?

  • Blunting of individual effect
  • Antagonistic effect
  • Independent effect
  • Synergy-like effect (correct)

What was the only variable significantly associated with mortality in the study?

  • Renal illness
  • Cardiovascular illness (correct)
  • Neurosurgical illness
  • Pulmonary illness

Why is sulbactam preferred over clavulanic acid in Acinetobacter infections?

  • Because sulbactam is less expensive
  • Because clavulanic acid is more toxic
  • Because sulbactam is more active peripherally (correct)
  • Because sulbactam is more widely available

What type of patients are at risk of Acinetobacter infections?

<p>Patients with urinary catheters, central line catheters, and wound infections (A)</p> Signup and view all the answers

What is the name of the bacterium that is associated with the usage of urethral catheters, central line catheters, and wound infections?

<p>A. calcoaceticus (D)</p> Signup and view all the answers

What is the term used to describe the comprehensive criteria used to evaluate the clinical efficacy of the drug combinations?

<p>Favorable clinical response criteria (D)</p> Signup and view all the answers

What percentage of Gram-negative infections in Intensive Care Units are attributed to baumannii complex?

<p>60% (D)</p> Signup and view all the answers

What is essential for an effective infection control program with minimal intervention?

<p>Frequent monitoring of body fluids (D)</p> Signup and view all the answers

What is a major concern regarding the use of carbapenems in treating Acinetobacter infections?

<p>Emergence of resistant isolates worldwide (A)</p> Signup and view all the answers

What is a promising avenue for combating CRAB infections, according to in vivo studies?

<p>Sulbactam combinations (A)</p> Signup and view all the answers

Why is sulbactam not affected by hemodialysis?

<p>It is not removed by kidney function (A)</p> Signup and view all the answers

What is a consequence of the increased use of carbapenems in treating E. coli and Salmonella infections?

<p>Increased resistance to carbapenems (D)</p> Signup and view all the answers

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