Podcast
Questions and Answers
What is the primary route of excretion for the nitrosoureas?
What is the primary route of excretion for the nitrosoureas?
- Kidney (correct)
- Lungs
- Skin
- Liver
Which alkylating agent undergoes biotransformation to form methyltriazenoimidazole carboxamide (MTIC)?
Which alkylating agent undergoes biotransformation to form methyltriazenoimidazole carboxamide (MTIC)?
- Carmustine
- Dacarbazine (correct)
- Temozolomide
- Lomustine
What is the primary mechanism of cytotoxic action of dacarbazine's metabolite?
What is the primary mechanism of cytotoxic action of dacarbazine's metabolite?
- Formation of DNA cross-links
- Inhibition of DNA synthesis
- Inhibition of RNA polymerase
- Methylation of DNA on the O-6 position of guanine (correct)
What is a unique characteristic of temozolomide compared to dacarbazine?
What is a unique characteristic of temozolomide compared to dacarbazine?
Which of the following agents is NOT administered orally?
Which of the following agents is NOT administered orally?
What is the target of temozolomide's inhibition, in addition to its effects on DNA methylation?
What is the target of temozolomide's inhibition, in addition to its effects on DNA methylation?
What is the primary mechanism of action of topoisomerase inhibitors?
What is the primary mechanism of action of topoisomerase inhibitors?
Which of the following is NOT a common adverse effect of topoisomerase inhibitors?
Which of the following is NOT a common adverse effect of topoisomerase inhibitors?
What is the primary indication for the use of topotecan?
What is the primary indication for the use of topotecan?
What is the approximate potency of SN-38 relative to irinotecan as an inhibitor of topoisomerase I?
What is the approximate potency of SN-38 relative to irinotecan as an inhibitor of topoisomerase I?
Why is frequent blood count monitoring necessary for patients receiving topotecan?
Why is frequent blood count monitoring necessary for patients receiving topotecan?
What is the primary difference in the mechanism of action of topoisomerase I and topoisomerase II inhibitors?
What is the primary difference in the mechanism of action of topoisomerase I and topoisomerase II inhibitors?
What is the primary route of administration for etoposide?
What is the primary route of administration for etoposide?
What is the primary mechanism of action of etoposide?
What is the primary mechanism of action of etoposide?
What is the primary toxicity associated with etoposide?
What is the primary toxicity associated with etoposide?
What is the indication for using atropine during irinotecan infusion?
What is the indication for using atropine during irinotecan infusion?
What is the target of monoclonal antibodies in anticancer therapy?
What is the target of monoclonal antibodies in anticancer therapy?
What is the family of enzymes involved in signal transduction and cell division?
What is the family of enzymes involved in signal transduction and cell division?
What is the mechanism by which proteasome inhibitors promote programmed cell death?
What is the mechanism by which proteasome inhibitors promote programmed cell death?
Why is the subcutaneous route preferred for administering bortezomib?
Why is the subcutaneous route preferred for administering bortezomib?
What is a common adverse effect of carfilzomib and bortezomib?
What is a common adverse effect of carfilzomib and bortezomib?
Which proteasome inhibitor is administered orally?
Which proteasome inhibitor is administered orally?
Why should patients receive antiviral prophylaxis when taking bortezomib?
Why should patients receive antiviral prophylaxis when taking bortezomib?
What is the primary purpose of coadministering prednisone with abiraterone acetate?
What is the primary purpose of coadministering prednisone with abiraterone acetate?
What is a common adverse effect associated with immuno-modulating agents such as thalidomide, lenalidomide, and pomalidomide?
What is a common adverse effect associated with immuno-modulating agents such as thalidomide, lenalidomide, and pomalidomide?
What is the mechanism of action of proteasome inhibitors such as bortezomib, ixazomib, and carfilzomib?
What is the mechanism of action of proteasome inhibitors such as bortezomib, ixazomib, and carfilzomib?
Why are lenalidomide and pomalidomide contraindicated in pregnancy?
Why are lenalidomide and pomalidomide contraindicated in pregnancy?
What is a potential adverse effect of abiraterone acetate?
What is a potential adverse effect of abiraterone acetate?
What is the primary indication for the use of immuno-modulating agents such as thalidomide, lenalidomide, and pomalidomide?
What is the primary indication for the use of immuno-modulating agents such as thalidomide, lenalidomide, and pomalidomide?
