25 Questions
What is a potential severe side effect of reserpine that led to its decline in use as an antihypertensive?
Severe depression that may lead to suicide
What is a contraindication associated with the use of reserpine?
Not specified
What is a common side effect of reserpine that can also be a symptom of depression?
Fatigue
Why is reserpine no longer commonly used as an antihypertensive?
Due to its severe depressive effects
What are two common side effects of reserpine?
Fatigue and insomnia
What is the primary indication of the medication?
Treatment of myasthenia gravis
What is the advantage of the oral formulation of the medication?
It has a longer duration of action with fewer side effects
What is the recommended oral dosing frequency of the medication?
60 mg four times daily
What is an alternative formulation of the medication?
Sustained release tablet
What is the daily oral dose of the medication?
240 mg or 60 mg four times daily
What is the primary concern when dealing with multiple constituents in a pharmaceutical preparation?
Ensuring the preparation's stability and potency
What can occur between constituents in a pharmaceutical preparation that may affect its quality?
Incompatibility
Why is it essential to consider the potential interactions between constituents in a pharmaceutical preparation?
To ensure the preparation's efficacy
What is the primary consequence of incompatibility between constituents in a pharmaceutical preparation?
Loss of stability and potency
What must be taken into account when combining multiple constituents in a pharmaceutical preparation?
The potential incompatibility between constituents
Which of the following is a characteristic of compounds transported through this mechanism?
It is selective
What is the direction of the concentration gradient in this mechanism?
Against the concentration gradient
Which of the following is required for this mechanism to occur?
Both a carrier and energy
What does Figure 3:6 signify?
Conc time profile of different routes of the same drug and dose
What is the process described in point 4?
Rate of elimination of the drug
What is the primary function of the carrier protein in this mechanism?
To bind and transport the compound
What is the characteristic that distinguishes this mechanism from other transport mechanisms?
It is a selective process
What is the process of getting the drug into the bloodstream called?
Absorption of the drug
What is the term for the movement of the drug from the bloodstream to the site of action?
Distribution of the drug
What is the term for the process by which the drug is broken down?
Metabolism of the drug
Study Notes
Reserpine
- May cause severe depression that can lead to suicide, which is why it's no longer commonly used as an antihypertensive.
- Side effects include orthostatic hypotension, weakness, fatigue, and insomnia.
Contraindications
- No specific contraindications mentioned, but its use is limited due to its side effects.
Uses of Reserpine
- Mainly used to treat myasthenia gravis.
- Administered orally in a dose of 60mg, 4 times a day, or in a sustained-release tablet format, which has a longer duration and fewer side effects.
Drug Incompatibility
- Pharmaceutical preparations may involve incompatibility between constituents, affecting the preparation's stability and potency.
- Important to consider these interactions when preparing medications.
Characteristics of a Mechanism
- Requires a carrier.
- Requires energy.
- Works against concentration gradient.
- Is selective.
- Transports compounds with high molecular weight.
Pharmacokinetics
- Figure 3:6 shows a concentration-time profile of different routes of administration of the same drug and dose.
- Important factors to consider in pharmacokinetics include:
- Distribution of the drug in the body.
- Rate of elimination of the drug.
This quiz covers the side effects and contraindications of antihypertensive medications, including reserpine.
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