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What is a potential severe side effect of reserpine that led to its decline in use as an antihypertensive?
What is a potential severe side effect of reserpine that led to its decline in use as an antihypertensive?
What is a contraindication associated with the use of reserpine?
What is a contraindication associated with the use of reserpine?
What is a common side effect of reserpine that can also be a symptom of depression?
What is a common side effect of reserpine that can also be a symptom of depression?
Why is reserpine no longer commonly used as an antihypertensive?
Why is reserpine no longer commonly used as an antihypertensive?
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What are two common side effects of reserpine?
What are two common side effects of reserpine?
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What is the primary indication of the medication?
What is the primary indication of the medication?
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What is the advantage of the oral formulation of the medication?
What is the advantage of the oral formulation of the medication?
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What is the recommended oral dosing frequency of the medication?
What is the recommended oral dosing frequency of the medication?
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What is an alternative formulation of the medication?
What is an alternative formulation of the medication?
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What is the daily oral dose of the medication?
What is the daily oral dose of the medication?
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What is the primary concern when dealing with multiple constituents in a pharmaceutical preparation?
What is the primary concern when dealing with multiple constituents in a pharmaceutical preparation?
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What can occur between constituents in a pharmaceutical preparation that may affect its quality?
What can occur between constituents in a pharmaceutical preparation that may affect its quality?
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Why is it essential to consider the potential interactions between constituents in a pharmaceutical preparation?
Why is it essential to consider the potential interactions between constituents in a pharmaceutical preparation?
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What is the primary consequence of incompatibility between constituents in a pharmaceutical preparation?
What is the primary consequence of incompatibility between constituents in a pharmaceutical preparation?
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What must be taken into account when combining multiple constituents in a pharmaceutical preparation?
What must be taken into account when combining multiple constituents in a pharmaceutical preparation?
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Which of the following is a characteristic of compounds transported through this mechanism?
Which of the following is a characteristic of compounds transported through this mechanism?
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What is the direction of the concentration gradient in this mechanism?
What is the direction of the concentration gradient in this mechanism?
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Which of the following is required for this mechanism to occur?
Which of the following is required for this mechanism to occur?
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What does Figure 3:6 signify?
What does Figure 3:6 signify?
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What is the process described in point 4?
What is the process described in point 4?
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What is the primary function of the carrier protein in this mechanism?
What is the primary function of the carrier protein in this mechanism?
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What is the characteristic that distinguishes this mechanism from other transport mechanisms?
What is the characteristic that distinguishes this mechanism from other transport mechanisms?
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What is the process of getting the drug into the bloodstream called?
What is the process of getting the drug into the bloodstream called?
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What is the term for the movement of the drug from the bloodstream to the site of action?
What is the term for the movement of the drug from the bloodstream to the site of action?
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What is the term for the process by which the drug is broken down?
What is the term for the process by which the drug is broken down?
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Study Notes
Reserpine
- May cause severe depression that can lead to suicide, which is why it's no longer commonly used as an antihypertensive.
- Side effects include orthostatic hypotension, weakness, fatigue, and insomnia.
Contraindications
- No specific contraindications mentioned, but its use is limited due to its side effects.
Uses of Reserpine
- Mainly used to treat myasthenia gravis.
- Administered orally in a dose of 60mg, 4 times a day, or in a sustained-release tablet format, which has a longer duration and fewer side effects.
Drug Incompatibility
- Pharmaceutical preparations may involve incompatibility between constituents, affecting the preparation's stability and potency.
- Important to consider these interactions when preparing medications.
Characteristics of a Mechanism
- Requires a carrier.
- Requires energy.
- Works against concentration gradient.
- Is selective.
- Transports compounds with high molecular weight.
Pharmacokinetics
- Figure 3:6 shows a concentration-time profile of different routes of administration of the same drug and dose.
- Important factors to consider in pharmacokinetics include:
- Distribution of the drug in the body.
- Rate of elimination of the drug.
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Description
This quiz covers the side effects and contraindications of antihypertensive medications, including reserpine.
