Antihypertensive Drugs II: Angiotensin Receptor Antagonists and Mineralocorticoid Receptor Antagonists
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Questions and Answers

Which mechanism is responsible for the long-term control of blood pressure by altering blood volume?

  • Stimulation of cardiac β1 receptors increasing heart rate and force of contraction
  • Baroreceptors and the sympathetic nervous system
  • Renin-angiotensin-aldosterone system (correct)
  • Stimulation of α1 receptors causing vasoconstriction

Which component of the renin-angiotensin-aldosterone system stimulates aldosterone secretion by the adrenal glands?

  • Angiotensin I
  • Angiotensinogen
  • Renin
  • Angiotensin II (correct)

What is the primary effect of stimulating α1 receptors in the context of blood pressure regulation?

  • Vasoconstriction (correct)
  • Increasing heart rate and force of contraction
  • Stimulating aldosterone secretion
  • Promoting rapid vasoconstriction

Which adverse effect of angiotensin-converting enzyme inhibitors (ACEI) is rare but potentially fatal?

<p>Angioedema (C)</p> Signup and view all the answers

Which of the following ACEIs does not require dose adjustment in patients with renal impairment?

<p>Fosinopril (A)</p> Signup and view all the answers

In which condition is Lisinopril preferred over other ACEIs?

<p>Severe hepatic impairment (B)</p> Signup and view all the answers

What is a compelling indication for the first-line treatment of hypertension with ACEIs?

<p>Chronic kidney disease (D)</p> Signup and view all the answers

What is the role of angiotensin-converting enzyme (ACE) in the Renin-Angiotensin–Aldosterone System?

<p>Converts angiotensin I to angiotensin II (D)</p> Signup and view all the answers

How do Angiotensin Receptor Antagonists work in the context of the Renin-Angiotensin–Aldosterone System?

<p>Block the AT1 receptor to prevent vasoconstriction (D)</p> Signup and view all the answers

What is the impact of decreased arterial pressure or volume depletion on the Renin-Angiotensin–Aldosterone System?

<p>Decreased GFR due to increased efferent arteriolar vasoconstriction (C)</p> Signup and view all the answers

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