10 Questions
What is the primary function of Class I MHC antigens?
To present endogenous antigens to CD8 cells
What is the approximate length of peptides bound to the MHC I groove?
8-10 amino acids
What is the function of the β2-microglobulin molecule in MHC I?
To maintain proper conformation of MHC I molecules
What is the primary function of the α3 domain of MHC I?
To serve as a binding site for CD8
What is the primary function of MHC class I molecules?
To present endogenous antigens to CD8 cells
Which type of cells typically express MHC class II molecules?
Professional antigen presenting cells
What is the nature of the transmembrane segment of MHC I molecules?
Hydrophobic
What is the primary function of the α1 and α2 domains of MHC I?
To form a highly polymorphic peptide binding cleft
Which type of cells can express MHC class I molecules?
Only nucleated cells
What is the homology between α3 and β2 microglobulin?
Homology with immunoglobulin constant regions
Test your understanding of antigen processing and presentation pathways, including the endogenous pathway and the role of MHC class I and II molecules. Learn how antigens are broken down into peptides and transported to the endoplasmic reticulum for presentation to T cells.
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