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Antigen Processing and Presentation Pathways

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Antigen Processing and Presentation Pathways

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Questions and Answers

What is the primary function of Class I MHC antigens?

To present endogenous antigens to CD8 cells (correct)

To bind with antibodies

To facilitate humoral immune response

To activate CD4 cells

What is the approximate length of peptides bound to the MHC I groove?

5-7 amino acids

20-25 amino acids

15-20 amino acids

8-10 amino acids (correct)

What is the function of the β2-microglobulin molecule in MHC I?

To maintain proper conformation of MHC I molecules (correct)

To interact with CD8 cells

To bind peptides

To recognize endogenous antigens

What is the primary function of the α3 domain of MHC I?

To serve as a binding site for CD8 Signup and view all the answers

What is the primary function of MHC class I molecules?

To present endogenous antigens to CD8 cells Signup and view all the answers

Which type of cells typically express MHC class II molecules?

Professional antigen presenting cells Signup and view all the answers

What is the nature of the transmembrane segment of MHC I molecules?

Hydrophobic Signup and view all the answers

What is the primary function of the α1 and α2 domains of MHC I?

To form a highly polymorphic peptide binding cleft Signup and view all the answers

Which type of cells can express MHC class I molecules?

Only nucleated cells Signup and view all the answers

What is the homology between α3 and β2 microglobulin?

Homology with immunoglobulin constant regions Signup and view all the answers