T cell lecture 1/2
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Questions and Answers

What is the main role of Follicular Helper T cells (T FH cells)?

  • Producing ROS
  • Activating macrophages
  • Killing infected cells
  • Activating B cells (correct)

    • Which subset of T cells stays in the lymph nodes to fight infection and does not egress to the site of infection?

  • CTLs
  • Follicular Helper T cells (correct)
  • Th1 cells
  • TH2 cells

    • What is responsible for directing T-cell differentiation into distinct effector cell types?

  • Signal 1
  • IL-2
  • Signal 2
  • Signal 3 (correct)

    • Which type of T cells differentiate into cytotoxic T lymphocytes (CTLs)?

    <p>Naïve CD8+ T cells</p> Signup and view all the answers

    What is the main function of Regulatory T cells?

    <p>Suppress immune responses</p> Signup and view all the answers

    What do activated effector T cells need to find their match and kill infected cells?

    <p>Co-stimulation interaction</p> Signup and view all the answers

    What molecule plays a role in restoring epithelial integrity after an infection is cleared?

    <p>CTLA-4</p> Signup and view all the answers

    What is the role of L-selectin in the immune response?

    <p>Targeting naive T cells to HEVs</p> Signup and view all the answers

    Which molecule binds to receptors on endothelial cells near inflamed tissue?

    <p>VLA-4</p> Signup and view all the answers

    What determines the fate of T cells according to the text?

    <p>Cytokines</p> Signup and view all the answers

    Which type of pathogens induce a Type 1 response in the immune system?

    <p>Viruses</p> Signup and view all the answers

    How do polarizing cytokines affect T cells?

    <p>Inducing transcription of new transcription factors</p> Signup and view all the answers

    Which proteins act as transcription factors after being phosphorylated by cytokine signaling?

    <p>STAT proteins</p> Signup and view all the answers

    What is the function of master transcriptional regulators in T cells?

    <p>Determining the function of different T cell subtypes</p> Signup and view all the answers

    Which type of immunity do extracellular pathogens like worms induce?

    <p>&quot;Humoral immunity&quot;</p> Signup and view all the answers

    How do polarizing cytokines guide T cells toward different effector fates?

    <p>By inducing signaling through STAT proteins</p> Signup and view all the answers

    Which type of cytokines are responsible for signaling the differentiation of T helper cell subsets?

    <p>Polarizing cytokines</p> Signup and view all the answers

    How does the expression of new transcription factors affect T cell subtype activity?

    <p>Induces the transcription of specific cytokine genes</p> Signup and view all the answers

    Which molecules determine the function of different T cells by regulating gene expression?

    <p>Master transcriptional regulators</p> Signup and view all the answers

    Which type of immunity is induced by extracellular pathogens like worms?

    <p>Humoral immunity</p> Signup and view all the answers

    What is the main function of APCs in the immune response related to effector T cells?

    <p>Producing polarizing cytokines</p> Signup and view all the answers

    What is the function of L-selectin in the immune response?

    <p>Guiding naïve T cells to lymph nodes</p> Signup and view all the answers

    What induces the expression of transcription factors like GATA-3 and T-Bet in T cells?

    <p>Cytokines secreted by APCs</p> Signup and view all the answers

    What is the main function of L-selectin and VLA-4 in the immune response?

    <p>Mediate T cell migration to sites of infection</p> Signup and view all the answers

    Which subset of T cells remains in the lymph nodes to combat infections without egressing to the site of infection?

    <p>CD4+ Follicular Helper T cells</p> Signup and view all the answers

    What is the primary role of CTLA4 in the immune system?

    <p>Downregulate T cell activity post-infection</p> Signup and view all the answers

    Which molecule is not required for activated effector T cells to find their match and kill infected cells?

    <p>$B7$</p> Signup and view all the answers

    What is the primary function of Regulatory T cells in adaptive immunity?

    <p>Inhibit excessive immune responses</p> Signup and view all the answers

    Which cytokines are responsible for promoting Th1 cell-mediated immunity?

    <p>$Th1$ cytokines</p> Signup and view all the answers

    What triggers the differentiation of Naïve CD8+ T cells into cytotoxic T lymphocytes?

    <p>$MHC$ I recognition</p> Signup and view all the answers

    'Signal 3' in T cell activation is primarily responsible for directing what process?

    <p>$CTL$ differentiation</p> Signup and view all the answers

    'Efferent lymphatics' play a role in transporting immune cells from lymph nodes to where in the body?

    <p>$Bloodstream$</p> Signup and view all the answers

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