Podcast
Questions and Answers
What is mandatory for the activation of naïve lymphocytes?
What is mandatory for the activation of naïve lymphocytes?
- Interaction of MHC/Ag and TCR (correct)
- Expression of specific signaling receptors
- Secretion of cytokines
- T-cell interaction with CD4
Which type of antigens are recognized by T cells in the context of intracellular pathogens?
Which type of antigens are recognized by T cells in the context of intracellular pathogens?
- Soluble antigens
- Conformational determinants of protein antigens
- Cell-associated antigens (correct)
- Non-linear peptides
What is a crucial role of Antigen Presenting Cells (APCs) in activating T cells?
What is a crucial role of Antigen Presenting Cells (APCs) in activating T cells?
- Inhibiting cytokine production
- Expressing MHC I exclusively
- Secreting antibodies
- Expressing co-stimulatory proteins (correct)
Why are linear peptides important in activating T cells in the case of extracellular pathogens?
Why are linear peptides important in activating T cells in the case of extracellular pathogens?
What is the significance of DC licensing by TH cells for APCs?
What is the significance of DC licensing by TH cells for APCs?
Which process is necessary to activate an antibody response?
Which process is necessary to activate an antibody response?
What initiates the activation of B cells in the humoral immune response?
What initiates the activation of B cells in the humoral immune response?
Which type of B cells are mainly involved in T-dependent antibody responses to protein antigens?
Which type of B cells are mainly involved in T-dependent antibody responses to protein antigens?
What is a characteristic of T-dependent antibody responses?
What is a characteristic of T-dependent antibody responses?
What stimulates the proliferation and differentiation of a specific B cell clone in the humoral immune response?
What stimulates the proliferation and differentiation of a specific B cell clone in the humoral immune response?
Which type of antibody response is slower to develop but results in long-lasting antibodies?
Which type of antibody response is slower to develop but results in long-lasting antibodies?
What can progeny of the B cell clone differentiate into in the humoral immune response?
What can progeny of the B cell clone differentiate into in the humoral immune response?
What is the main difference between the antibodies produced by plasmablasts in primary foci and those produced in the germinal center reaction?
What is the main difference between the antibodies produced by plasmablasts in primary foci and those produced in the germinal center reaction?
What enables the process of affinity maturation in B cells during the germinal center reaction?
What enables the process of affinity maturation in B cells during the germinal center reaction?
Where do plasma cells primarily migrate to in the case of the primary focus?
Where do plasma cells primarily migrate to in the case of the primary focus?
Which cells begin to emerge during the first 4-5 days of an immune response?
Which cells begin to emerge during the first 4-5 days of an immune response?
What is the role of somatic hypermutation in the germinal center reaction?
What is the role of somatic hypermutation in the germinal center reaction?
Where do plasmablasts migrate to after interacting with activated helper T cells?
Where do plasmablasts migrate to after interacting with activated helper T cells?
What is the role of Fc receptors in the humoral immune response?
What is the role of Fc receptors in the humoral immune response?
Which molecules bind to the Fc receptors on phagocytes in the humoral immune response?
Which molecules bind to the Fc receptors on phagocytes in the humoral immune response?
How do bacteria resist limited phagocytosis by macrophages?
How do bacteria resist limited phagocytosis by macrophages?
What is the consequence of bacteria being coated with IgG antibody and complement?
What is the consequence of bacteria being coated with IgG antibody and complement?
How do Fc receptors and complement receptors synergize in inducing phagocytosis?
How do Fc receptors and complement receptors synergize in inducing phagocytosis?
What happens when macrophage membranes fuse during phagocytosis?
What happens when macrophage membranes fuse during phagocytosis?
What is required to drive naïve CD8 T cells to become activated?
What is required to drive naïve CD8 T cells to become activated?
What is a key role of CD4 effector T cells in supporting the activation of CD8 T cells?
What is a key role of CD4 effector T cells in supporting the activation of CD8 T cells?
Which molecules increase on antigen-presenting cells following stimulation through CD40 to co-stimulate naïve CD8 T cells?
Which molecules increase on antigen-presenting cells following stimulation through CD40 to co-stimulate naïve CD8 T cells?
How do activated dendritic cells prime naïve CD8 T cells for activation?
How do activated dendritic cells prime naïve CD8 T cells for activation?
What is the role of IL-2 in the process of activating CD8+ T cells?
What is the role of IL-2 in the process of activating CD8+ T cells?
How do cytotoxic CD8+ T cells induce apoptosis in target cells?
How do cytotoxic CD8+ T cells induce apoptosis in target cells?
