Antigen Presentation and T-Cell Activation Quiz
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Questions and Answers

What is mandatory for the activation of naïve lymphocytes?

  • Interaction of MHC/Ag and TCR (correct)
  • Expression of specific signaling receptors
  • Secretion of cytokines
  • T-cell interaction with CD4

    • Which type of antigens are recognized by T cells in the context of intracellular pathogens?

  • Soluble antigens
  • Conformational determinants of protein antigens
  • Cell-associated antigens (correct)
  • Non-linear peptides

    • What is a crucial role of Antigen Presenting Cells (APCs) in activating T cells?

  • Inhibiting cytokine production
  • Expressing MHC I exclusively
  • Secreting antibodies
  • Expressing co-stimulatory proteins (correct)

    • Why are linear peptides important in activating T cells in the case of extracellular pathogens?

    <p>They are more immunogenic</p> Signup and view all the answers

    What is the significance of DC licensing by TH cells for APCs?

    <p>Activates naive T cells</p> Signup and view all the answers

    Which process is necessary to activate an antibody response?

    <p>Interaction between B cells and T cells</p> Signup and view all the answers

    What initiates the activation of B cells in the humoral immune response?

    <p>Antigens recognized by the surface Ig receptors</p> Signup and view all the answers

    Which type of B cells are mainly involved in T-dependent antibody responses to protein antigens?

    <p>Follicular B cells</p> Signup and view all the answers

    What is a characteristic of T-dependent antibody responses?

    <p>Production of high-affinity antibodies</p> Signup and view all the answers

    What stimulates the proliferation and differentiation of a specific B cell clone in the humoral immune response?

    <p>Helper T cells</p> Signup and view all the answers

    Which type of antibody response is slower to develop but results in long-lasting antibodies?

    <p><em>T-dependent antibody response</em></p> Signup and view all the answers

    What can progeny of the B cell clone differentiate into in the humoral immune response?

    <p><em>Both plasma cells and memory cells</em></p> Signup and view all the answers

    What is the main difference between the antibodies produced by plasmablasts in primary foci and those produced in the germinal center reaction?

    <p>Primary foci antibodies are of the IgM isotype, while germinal center antibodies are more effective in eliminating infections.</p> Signup and view all the answers

    What enables the process of affinity maturation in B cells during the germinal center reaction?

    <p>Somatic hypermutation</p> Signup and view all the answers

    Where do plasma cells primarily migrate to in the case of the primary focus?

    <p>Bone marrow</p> Signup and view all the answers

    Which cells begin to emerge during the first 4-5 days of an immune response?

    <p>Plasmablasts, germinal center B cells, and early memory B cells</p> Signup and view all the answers

    What is the role of somatic hypermutation in the germinal center reaction?

    <p>Alters the V regions of immunoglobulin genes</p> Signup and view all the answers

    Where do plasmablasts migrate to after interacting with activated helper T cells?

    <p>Bone marrow</p> Signup and view all the answers

    What is the role of Fc receptors in the humoral immune response?

    <p>Facilitate phagocytosis of bacteria coated with antibodies</p> Signup and view all the answers

    Which molecules bind to the Fc receptors on phagocytes in the humoral immune response?

    <p>CR1 and IgG antibody</p> Signup and view all the answers

    How do bacteria resist limited phagocytosis by macrophages?

    <p>By coating themselves with antibodies and complement</p> Signup and view all the answers

    What is the consequence of bacteria being coated with IgG antibody and complement?

    <p>They are more readily ingested and degraded by phagocytes</p> Signup and view all the answers

    How do Fc receptors and complement receptors synergize in inducing phagocytosis?

    <p>By working together to promote bacterial uptake</p> Signup and view all the answers

    What happens when macrophage membranes fuse during phagocytosis?

    <p>They create a membrane-enclosed vesicle called a phagosome</p> Signup and view all the answers

    What is required to drive naïve CD8 T cells to become activated?

    <p>Stimulation of APC through CD40</p> Signup and view all the answers

    What is a key role of CD4 effector T cells in supporting the activation of CD8 T cells?

    <p>Inducing the self production of IL-2 by CD8 T cells</p> Signup and view all the answers

    Which molecules increase on antigen-presenting cells following stimulation through CD40 to co-stimulate naïve CD8 T cells?

    <p>B7 and 4-1BBL</p> Signup and view all the answers

    How do activated dendritic cells prime naïve CD8 T cells for activation?

    <p>By inducing the self-production of IL-2 by CD8 T cells</p> Signup and view all the answers

    What is the role of IL-2 in the process of activating CD8+ T cells?

    <p>Promotes the proliferation and survival of activated T cells</p> Signup and view all the answers

    How do cytotoxic CD8+ T cells induce apoptosis in target cells?

    <p>Via intrinsic and extrinsic pathways using receptors and perforin</p> Signup and view all the answers

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