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Questions and Answers
What is required for the formation of a visible precipitate in antigen-antibody reactions?
What is required for the formation of a visible precipitate in antigen-antibody reactions?
- Monovalent antibody and bivalent or polyvalent antigen
- Monovalent antibody and monovalent antigen
- Bivalent antibody and bivalent or polyvalent antigen (correct)
- Bivalent antibody and monovalent antigen
What are antibodies called when they aggregate soluble antigens?
What are antibodies called when they aggregate soluble antigens?
- Agglutinins
- Opsonins
- Precipitins (correct)
- Neutralizing antibodies
What is the purpose of centrifuging the tubes in a quantitative precipitation reaction?
What is the purpose of centrifuging the tubes in a quantitative precipitation reaction?
- To separate the antibody and antigen
- To pellet the precipitate (correct)
- To mix the antibody and antigen
- To measure the amount of antigen
What does a precipitin curve measure?
What does a precipitin curve measure?
What type of antigen is required for the formation of an Ag-Ab lattice?
What type of antigen is required for the formation of an Ag-Ab lattice?
Flashcards
Precipitins
Precipitins
Antibodies that cause soluble antigens to clump together.
Bivalent antibody
Bivalent antibody
An antibody that binds to two antigen sites at the same time, promoting cross-linking and precipitation.
Bivalent or Polyvalent Antigen
Bivalent or Polyvalent Antigen
An antigen that can bind to multiple antibody molecules at the same time, forming a large, insoluble complex.
Centrifugation
Centrifugation
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Precipitin curve
Precipitin curve
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Study Notes
Antigen-Antibody Reactions
- A visible precipitate forms when antigen-antibody complexes aggregate to a size that can be seen, requiring a sufficient concentration of both antigen and antibody.
- Antibodies that aggregate soluble antigens are called precipitins.
Quantitative Precipitation Reaction
- Centrifuging the tubes in a quantitative precipitation reaction separates the precipitate from the supernatant, allowing for measurement of the precipitate.
Precipitin Curve
- A precipitin curve measures the amount of precipitate formed as a function of antigen concentration, providing a quantitative representation of the antigen-antibody reaction.
Antigen Requirements
- For the formation of an Ag-Ab lattice, a multivalent antigen (having multiple epitopes) is required, allowing for the cross-linking of antibodies and subsequent precipitation.
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Description
Test your knowledge of antigen-antibody reactions with this clinical immunity quiz. Explore the concepts of precipitins and the formation of visible precipitates. Ideal for medical students and professionals seeking to deepen their understanding of immunology.