Antifungal Drugs: Griseofulvin and Fungal Growth Inhibition

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Questions and Answers

Which class of antifungal drugs inhibits squalene epoxidase, an essential step in ergosterol synthesis?

  • Triazoles
  • Echinocandins
  • Allylamines (correct)
  • Azoles

Which antifungal drug class is considered less toxic than the Imidazole azoles?

  • Echinocandins
  • Allylamines
  • Triazoles (correct)
  • Griseofulvin

Which antifungal drug class inhibits the synthesis of $ß(1,3)$-glucan, a major component of the fungal cell wall?

  • Echinocandins (correct)
  • Azoles
  • Allylamines
  • Triazoles

Which antifungal drug is used to treat both cutaneous and vaginal candidiasis?

<p>Fluconazole (B)</p> Signup and view all the answers

Which antifungal drug class has a broad spectrum of activity, including treatment of chromoblastomycosis, histoplasmosis, and coccidioidomycosis?

<p>Itraconazole (D)</p> Signup and view all the answers

Which antifungal drug class is used for the topical treatment of dermatophyte infections like tinea pedis and tinea corporis?

<p>Allylamines (A)</p> Signup and view all the answers

Which class of antifungal drugs inhibits ergosterol synthesis by inhibiting the enzyme 14-alpha-demethylase?

<p>Azoles (D)</p> Signup and view all the answers

Which type of antifungal drug disrupts spindle formation, thus preventing mitosis?

<p>Griseofulvin (C)</p> Signup and view all the answers

Which antifungal drug class targets the fungal cell wall by inhibiting $b-(1,3)$-glucan synthase?

<p>Echinocandins (A)</p> Signup and view all the answers

Which antifungal drug class is chemically synthesized and inhibits the fungal enzyme lanosterol 14-alpha-demethylase?

<p>Triazoles (B)</p> Signup and view all the answers

Which antifungal drug is effective against candidiasis and cryptococcosis, and is often used synergistically with amphotericin B?

<p>Flucytosine (A)</p> Signup and view all the answers

Which class of antifungal drugs disrupts the fungal cell membrane by binding to ergosterol?

<p>Polyenes (B)</p> Signup and view all the answers

Which class of antifungal drugs targets the fungal cell wall by inhibiting the enzyme $eta$-1,3-D-glucan synthase?

<p>Echinocandins (D)</p> Signup and view all the answers

Which antifungal drug class inhibits the enzyme squalene epoxidase, leading to the accumulation of toxic sterols in the fungal cell membrane?

<p>Allylamines (C)</p> Signup and view all the answers

Which antifungal drug class inhibits the biosynthesis of ergosterol, a key component of the fungal cell membrane?

<p>Azoles (D)</p> Signup and view all the answers

Which class of antifungal drugs is derived from a natural product and interferes with microtubule formation, preventing fungal cell division?

<p>Griseofulvin (C)</p> Signup and view all the answers

Which antifungal drug class inhibits fungal cell division by interfering with microtubule function?

<p>Griseofulvin (C)</p> Signup and view all the answers

Which antifungal drug class targets the fungal cell membrane by inhibiting the enzyme squalene epoxidase, a key step in ergosterol biosynthesis?

<p>Allylamines (C)</p> Signup and view all the answers

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