Antiemetics and Antinausea Drugs

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Questions and Answers

A patient on warfarin (Coumadin) tells the nurse they take ginger daily for nausea. Why is this concerning?

  • Ginger decreases the effectiveness of warfarin, potentially leading to blood clots.
  • Ginger interacts with warfarin, causing severe gastrointestinal distress.
  • Ginger blocks the absorption of warfarin, leading to subtherapeutic levels.
  • Ginger increases the anticoagulant effects of warfarin, increasing the risk of bleeding. (correct)

Administering antiemetics with alcohol is generally safe as they counteract each other's effects.

False (B)

What is the recommended timeframe for administering antiemetics before chemotherapy to maximize their effectiveness?

30-60 minutes

Patients should be taught to change positions slowly to avoid ______ effects when taking antiemetics.

<p>hypotensive</p> Signup and view all the answers

Match the following enteral nutrition formulations with their primary characteristic:

<p>Elemental = Minimal digestion needed, used for malabsorption Polymeric = Preferred for patients with functional GI tracts, resembles normal diet Modular = Single-nutrient formulas used with other formulations Altered Amino Acid = For patients with altered metabolism capacities</p> Signup and view all the answers

Which of these conditions indicates a potential need for feeding tubes and enteral nutrition?

<p>Depressed consciousness (C)</p> Signup and view all the answers

Hyperosmolarity of enteral formulas is unlikely to cause any gastrointestinal problems.

<p>False (B)</p> Signup and view all the answers

A patient receiving enteral nutrition exhibits nausea, weakness, sweating and palpitations shortly after feeding. Which complication is most likely occurring?

<p>Dumping syndrome (C)</p> Signup and view all the answers

A patient receiving enteral feeding exhibits signs of lactose intolerance. Which action is most appropriate?

<p>Decrease the feeding rate and monitor for further signs of intolerance. (D)</p> Signup and view all the answers

Parenteral nutrition bypasses the gastrointestinal system, eliminating the need for absorption, metabolism, and excretion.

<p>False (B)</p> Signup and view all the answers

List three potential components of a TPN formulation that address individual patient nutritional needs.

<p>Calories, amino acids, carbohydrates</p> Signup and view all the answers

Peripheral TPN is typically used for short-term nutritional support, generally less than ______ weeks.

<p>2</p> Signup and view all the answers

Match the following TPN administration routes with their typical duration of use:

<p>Peripheral TPN = Temporary, short term Central TPN = Long-term use</p> Signup and view all the answers

Which of the following is a potential risk specifically associated with central TPN, but not typically with peripheral TPN?

<p>Infection (C)</p> Signup and view all the answers

If TPN is discontinued abruptly, there is a risk of rebound hyperglycemia due to the pancreas's continued high insulin production.

<p>False (B)</p> Signup and view all the answers

A nurse is monitoring a patient receiving TPN and notices symptoms such as headache, dehydration, and weakness. These findings are most indicative of which complication?

<p>Hyperglycemia (B)</p> Signup and view all the answers

Which of the following antiemetic drug classes primarily targets the inner ear labyrinth to prevent transmission of nauseating stimuli to the chemoreceptor trigger zone (CTZ)?

<p>Anticholinergic drugs (B)</p> Signup and view all the answers

Administering hydroxyzine intravenously is a safe and preferred method due to its rapid effect on reducing nausea.

<p>False (B)</p> Signup and view all the answers

What is the primary mechanism of action of prokinetic drugs in treating nausea and vomiting related to gastroesophageal reflux disease?

<p>stimulating peristalsis in the GI tract</p> Signup and view all the answers

Serotonin blockers such as ondansetron are particularly effective in managing nausea and vomiting associated with ________ and postoperative conditions.

<p>chemotherapy</p> Signup and view all the answers

Match the following antiemetic drug types with their primary mechanism of action:

<p>Antihistamines (H1 receptor blockers) = Prevent cholinergic stimulation in vestibular and reticular areas. Antidopaminergic drugs = Block dopamine receptors in the chemoreceptor trigger zone (CTZ). Serotonin blockers = Block serotonin receptors in the GI tract, CTZ, and vomiting center. Prokinetic drugs = Stimulate peristalsis in GI tract, enhancing emptying of stomach contents.</p> Signup and view all the answers

A patient is prescribed ondansetron intravenously. What is the recommended maximum dose and administration time to minimize the risk of dysrhythmia?

<p>Up to 8mg IV push over 5 minutes (A)</p> Signup and view all the answers

Tetrahydrocannabinoids (THC) relieve nausea and vomiting by directly activating dopamine receptors in the vomiting center.

<p>False (B)</p> Signup and view all the answers

When educating a patient about taking anti-nausea medications, which instruction is most important to include?

<p>Avoid performing hazardous tasks due to potential drowsiness. (D)</p> Signup and view all the answers

Why are antiemetics often administered 30 to 60 minutes before chemotherapy?

<p>To prevent nausea and vomiting associated with chemotherapy. (A)</p> Signup and view all the answers

Taking antiemetics with alcohol may cause severe central nervous system stimulation.

<p>False (B)</p> Signup and view all the answers

What specific instruction should nurses provide to patients taking antiemetics to prevent hypotensive effects?

<p>change positions slowly</p> Signup and view all the answers

A patient taking ginger regularly should be monitored, especially if they are also taking ______ due to potential interactions.

<p>warfarin</p> Signup and view all the answers

Which type of enteral formula is most appropriate for patients with fully functional GI tracts and few specialized nutrient requirements?

<p>Polymeric (D)</p> Signup and view all the answers

Which of the following antiemetic drug classes works by inhibiting acetylcholine, thus preventing cholinergic stimulation in the vestibular and reticular areas?

<p>Antihistamine drugs (H1 receptor blockers) (C)</p> Signup and view all the answers

Modular enteral formulas provide a complete nutritional profile in a single formulation.

<p>False (B)</p> Signup and view all the answers

A patient receiving enteral nutrition suddenly develops nausea, weakness, sweating, and palpitations. Which adverse effect is the most likely cause?

<p>Dumping syndrome (C)</p> Signup and view all the answers

Prokinetic drugs work by blocking dopamine receptors in the chemoreceptor trigger zone (CTZ) and stimulating peristalsis in the GI tract.

<p>True (A)</p> Signup and view all the answers

What is a significant risk associated with the intravenous (IV) administration of promethazine?

<p>Intra-arterial entry and amputation</p> Signup and view all the answers

Match the following enteral nutrition types with their appropriate usage:

<p>Elemental = Malabsorption, IBD Polymeric = Fully functional GI tract Modular = Single-nutrient supplement Glucerna = Impaired glucose tolerance</p> Signup and view all the answers

Serotonin blockers, such as ondansetron, are primarily used to treat nausea and vomiting associated with ______ and postoperative states.

<p>chemotherapy</p> Signup and view all the answers

Match the antiemetic drug with its primary mechanism of action:

<p>Anticholinergic drugs = Block acetylcholine receptors in the inner ear labyrinth Antidopaminergic drugs = Block dopamine receptors in the chemoreceptor trigger zone (CTZ) Serotonin blockers = Block serotonin receptors in the GI tract, CTZ, and vomiting center Prokinetic drugs = Desensitize the CTZ to impulses from the GI tract and stimulate peristalsis</p> Signup and view all the answers

A patient with glaucoma should avoid which type of anti-nausea medication?

<p>Anticholinergics (B)</p> Signup and view all the answers

Which of the following statements is correct regarding the use of ondansetron (Zofran®)?

<p>It can be given IV push over 5 minutes up to 8mg (A)</p> Signup and view all the answers

Ginger may decrease the absorption of oral medications.

<p>False (B)</p> Signup and view all the answers

A patient receiving enteral feeding exhibits signs of lactose intolerance. What is the most appropriate initial nursing action?

<p>Administer lactase enzyme supplements as prescribed. (D)</p> Signup and view all the answers

Parenteral nutrition requires the normal functioning of the gastrointestinal system for nutrient absorption.

<p>False (B)</p> Signup and view all the answers

What is a primary risk associated with administering peripheral TPN due to the lower concentration of dextrose?

<p>phlebitis</p> Signup and view all the answers

Central TPN is preferred over peripheral TPN when nutritional support is needed for a period longer than ______ days.

<p>7 to 10</p> Signup and view all the answers

Which of the following is NOT a typical indication for peripheral parenteral nutrition?

<p>Supporting patients with severe gastrointestinal illnesses preventing oral intake. (C)</p> Signup and view all the answers

Match each potential complication with its corresponding sign or symptom in a patient receiving TPN:

<p>Hyperglycemia = Headache, dehydration, weakness Hypoglycemia = Cold, clammy skin; dizziness; tachycardia Fluid Overload = Edema, increased blood pressure, shortness of breath Infection = Fever, chills, redness at insertion site</p> Signup and view all the answers

A patient's TPN is abruptly discontinued due to unforeseen circumstances. Which intervention is most important to prevent rebound hypoglycemia?

<p>Infuse 5% to 10% dextrose solution per facility protocol. (C)</p> Signup and view all the answers

Increased thirst is a sign of hypoglycemia in patients receiving TPN.

<p>False (B)</p> Signup and view all the answers

Flashcards

Antiemetics

Drugs that help prevent nausea and vomiting.

Chemoreceptor trigger zone (CTZ)

Area in the brain that triggers vomiting when stimulated by noxious stimuli.

Antihistamines (H1 receptor blockers)

Block acetylcholine, preventing cholinergic stimulation in vestibular and reticular areas; used for motion sickness.

Antidopaminergic drugs

Block dopamine receptors in the CTZ; also used for psychotic disorders and hiccups.

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Anticholinergic drugs

Bind to and block acetylcholine receptors in the inner ear, blocking transmission of nauseating stimuli to CTZ.

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Prokinetic drugs

Block dopamine receptors in the CTZ and stimulate peristalsis in the GI tract to enhance emptying of stomach contents.

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Serotonin Blockers

Block serotonin receptors in the GI tract, CTZ, and vomiting center; used for chemotherapy-induced nausea.

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Tetrahydrocannabinoids

Affects reticular formation, thalamus, and cerebral cortex, altering mood and body perception to relieve nausea.

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Antiemetics and alcohol

Severe nervous system depression can occur.

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Changing positions slowly

To reduce the risk of orthostatic hypotension.

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Antiemetics timing for chemo

Administer 30-60 minutes before chemotherapy.

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Ginger and Warfarin (Coumadin)

Monitor for increased bleeding risk when taken with ginger.

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Indications for feeding tubes

Abnormal peristalsis, altered anatomy, depressed consciousness, impaired digestive capacity.

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Elemental Enteral Nutrition

Minimal digestion needed, used for malabsorption. But high osmolarity can cause GI issues.

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Polymeric Enteral Nutrition

Preferred for patients with fully functional GI tracts. Resembles normal dietary intake.

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Symptoms of Dumping Syndrome

Nausea, weakness, sweating, palpitations, syncope, warmth, diarrhea.

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Parenteral Nutrition

Nutrients given intravenously, bypassing the GI system.

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Peripheral TPN

Temporary TPN, dextrose concentration less than 10%.

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Central TPN

TPN for long-term use, higher dextrose concentration (10-50%).

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Indications for Peripheral TPN

Used when the patient's intake isn't enough. Procedures restrict oral feedings, anorexia caused by chemotherapy or radiation treatments

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Central TPN Delivery

Delivered through a large central vein (subclavian, internal jugular) for long-term nutritional support.

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Central TPN Risks

Trauma from catheter insertion; metabolic changes like hyperglycemia; infection risk is high due to lines.

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TPN & Insulin

The pancreas overproduces insulin, which can cause hypoglycemia if TPN stops suddenly.

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Hyperglycemia Symptoms (TPN)

Headache, dehydration, and weakness are some signs of this condition.

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Enteral Feeding Start

Gradually increasing the rate of feeding.

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TPN Components

Calories, amino acids, carbohydrates, fats, trace elements, vitamins, and minerals.

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Peripheral TPN Duration

Temporary, short-term; dextrose concentration less than 10%.

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Peripheral TPN Indications

Procedures that restrict oral feedings, Anorexia, GI illness, Post-surgery.

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Central TPN Vein

Subclavian or internal jugular.

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Hyperglycemia symptoms with TPN

Headache, dehydration, weakness.

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Orthostatic Hypotension

Change positions slowly to avoid this side effect, especially with antiemetics.

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Ginger and Warfarin

When ginger is taken with this medication, it increases the risk of bleeding.

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Glucerna

Formulas containing proteins, carbohydrates, fat, sodium, and potassium used for patients with impaired glucose tolerance.

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Dumping Syndrome Symptoms

Diarrhea, nausea, weakness, sweating, palpitations, syncope, sensations of warmth.

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Enteral Tube Placement

Follow facility policy for ensuring proper placement and checking residual volumes.

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Flushing Feeding Tubes

Follow procedures for flushing tubing to prevent clogging.

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Monitoring Enteral Feedings

Carefully monitor patient's tolerance to the feedings.

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Vomiting Chemoreceptor Trigger Zone

The area that sends signals to the vomiting center when stimulated by noxious substances.

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Anticholinergic Anti-nausea Drugs

A type of drug that blocks the action of acetylcholine, helping to reduce nausea.

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Antihistamine Anti-nausea Drugs

Medications that work by inhibiting histamine H1 receptors to reduce nausea and vomiting.

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Antidopaminergic Anti-nausea Drugs

Drugs that prevent nausea and vomiting by blocking dopamine receptors in the chemoreceptor trigger zone (CTZ).

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Prokinetic Anti-nausea Drugs

Medications that enhance gastric emptying by blocking dopamine receptors and stimulating peristalsis.

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Serotonin Blocker Anti-nausea Drugs

Drugs that act on the GI tract, CTZ, and vomiting center to prevent nausea and vomiting, especially from chemotherapy.

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Doxylamine/Pyridoxine

A drug combination of antihistamine and vitamin B6 used to treat morning sickness.

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Study Notes

  • Nausea and vomiting occurs when the chemoreceptor trigger zone sends signals to the vomiting centre, signaling noxious stimuli.
  • Signals chemoreceptors respond to include Acetylcholine (Ach), D2, H1, PG, and S (5-HT3)

Sites of Action of Antinausea Drugs

  • Gastrointestinal tract: prokinetic drugs and serotonin blockers site of action
  • Labyrinth (inner ear): anticholinergics, antihistamines, neuroleptics, and prokinetic drugs site of action
  • Chemoreceptor trigger zone (CTZ): neuroleptics, prokinetic drugs site of action
  • Cerebral cortex: Tetrahydrocannabinol (THC), Corticosteroids, and Benzodiazepines site of action
  • Vomiting centre (medulla): serotonin blockers site of action

Nursing Implications for Ginger

  • Always determine if a patient is taking warfarin (Coumadin®) if they say they take ginger daily. Risk of bleeding greatly increases.

Tube Feeding Routes

  • Routes include: nasogastric, esophagostomy, nasoduodenal or nasojejunal, gastrostomy, jejunostomy

TPN Policies and Procedures

  • Agency specific, with HSN TPN order set and HSN procedure.
  • Routine daily labs: lipid profile, INR.
  • Check glucose Q6H and weights Q Mondays and Thursdays.
  • TPN can be held for blood administration, rate may need changed.

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